Taletrectinib (CAS 1505514-27-1): price, suppliers and safety

What is Taletrectinib?

Plain description, key identifiers and synonyms

Taletrectinib is an orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration, taletrectinib binds to and inhibits ROS1 and the NTRK family members. This inhibition leads to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells. NTRK mutations or rearrangements play a key role in cancer progression.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine
CAS number: 1505514-27-1Other or deprecated CAS: 1505515-69-4
Molecular formula: C₂₃H₂₄FN₅O
UNII: W4141180YD
InChIKey: HEVHTYMYEMEBPX-HZPDHXFCSA-N
InChI: InChI=1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13,15-16H,14,25H2,1-2H3,(H,27,28)/t15-,16-/m1/s1
Canonical SMILES: CC(N)COc1ccc(-c2cnc3ccc(NC(C)c4cccc(F)c4)nn23)cc1
Isomeric SMILES: C[C@H](COC1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)N[C@H](C)C4=CC(=CC=C4)F)N

Synonyms

DS-6051a
3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine
3-(4-((2R)-2-Aminopropoxy)phenyl)-N-((1R)-1-(3-fluorophenyl)ethyl)imidazo(1,2-b)pyridazin-6-amine
Taletrectinib free base
Taletrectinib (free base)
3-(4-((R)-2-Aminopropoxy)phenyl)-N-((R)-1-(3-fluorophenyl)ethyl)imidazo[1,2-b]pyridazin-6-amine
Taletrectinib (USAN/INN)
WHO 11404
3-{4-[(2R)-2-aminopropoxy]phenyl}-N-[(1R)-1-(3- fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine
Imidazo[1,2-b]pyridazin-6-amine, 3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	405.48 g/molcalc.
Exact mass	405.1965 Dacalc.
LogP (octanol/water)	4.43calc.
Topological polar surface area	77.47 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	5calc.
Rotatable bonds	7calc.
Heavy atoms	30calc.
Rings	4calc.
Aromatic rings	4calc.
Fraction sp3 carbons	0.22calc.
Formal charge	0calc.
Stereocentres	2calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

c1ccc(CNc2ccc3ncc(-c4ccccc4)n3n2)cc1

4 rings, 23 atoms.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Taletrectinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

No supplier listings yet

Post one free request and suppliers who make or trade Taletrectinib can send you quotes. Your contact details stay private until you accept a quote.

Request quotes Sell this chemical

Taletrectinib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

Antineoplastic Agents
Tyrosine Kinase Inhibitors

Roles

antineoplastic agent
pharmaceutical

Pharmacology

Taletrectinib is a Kinase Inhibitor. The mechanism of action of taletrectinib is as a Proto-Oncogene Tyrosine-Protein Kinase ROS1 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Taletrectinib is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024

$12.1B

−31.0% vs 2023, imports $28.8B

2019 to 2024

Top exporters

China30.5%
India * partner reported16.3%
Ireland9.0%

Top importers

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Taletrectinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

3-[4-[(2R)-2-Aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine, hexanedioic acid chemical structure, C29H34FN5O5, CAS 1505515-69-4

3-[4-[(2R)-2-Aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine, hexanedioic acid1505515-69-4C₂₉H₃₄FN₅O₅2 suppliers

Same formula isomers

Different compounds that share this molecular formula

All isomers

1-(4-Fluorophenyl)-3-(4-((4-(pyridin-2-yl)piperazin-1-yl)methyl)phenyl)urea chemical structure, C23H24FN5O, CAS 1171095-63-8

1-(4-Fluorophenyl)-3-(4-((4-(pyridin-2-yl)piperazin-1-yl)methyl)phenyl)urea1171095-63-8C₂₃H₂₄FN₅O

2-(4-(1-(2-Fluorophenyl)-1H-imidazol-2-yl)piperazin-1-yl)-1-(indolin-1-yl)ethanone chemical structure, C23H24FN5O, CAS 1021036-90-7

2-(4-(1-(2-Fluorophenyl)-1H-imidazol-2-yl)piperazin-1-yl)-1-(indolin-1-yl)ethanone1021036-90-7C₂₃H₂₄FN₅O

4-[6-(2,4-Dimethylphenyl)pyridazin-3-yl]-N-(2-fluorophenyl)piperazine-1-carboxamide chemical structure, C23H24FN5O, CAS 1058192-97-4

4-[6-(2,4-Dimethylphenyl)pyridazin-3-yl]-N-(2-fluorophenyl)piperazine-1-carboxamide1058192-97-4C₂₃H₂₄FN₅O

N-(3-Fluoro-4-methylphenyl)-4-(6-(o-tolyl)pyridazin-3-yl)piperazine-1-carboxamide chemical structure, C23H24FN5O, CAS 1060177-38-9

N-(3-Fluoro-4-methylphenyl)-4-(6-(o-tolyl)pyridazin-3-yl)piperazine-1-carboxamide1060177-38-9C₂₃H₂₄FN₅O

2-Amino-1-(4-fluorobenzyl)-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide chemical structure, C23H24FN5O, CAS 500271-63-6

2-Amino-1-(4-fluorobenzyl)-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide500271-63-6C₂₃H₂₄FN₅O

2-(4-Fluorophenyl)-1-(4-(6-(p-tolylamino)pyridazin-3-yl)piperazin-1-yl)ethanone chemical structure, C23H24FN5O, CAS 1226432-13-8

2-(4-Fluorophenyl)-1-(4-(6-(p-tolylamino)pyridazin-3-yl)piperazin-1-yl)ethanone1226432-13-8C₂₃H₂₄FN₅O

N-[6-(4-Benzylpiperazin-1-yl)pyrimidin-4-yl]-2-(4-fluorophenyl)acetamide chemical structure, C23H24FN5O, CAS 1396686-63-7

N-[6-(4-Benzylpiperazin-1-yl)pyrimidin-4-yl]-2-(4-fluorophenyl)acetamide1396686-63-7C₂₃H₂₄FN₅O

N-[1-(4-Fluorobenzyl)-4-piperidyl]-3-(2-pyrimidinylamino)benzamide chemical structure, C23H24FN5O, CAS 1435981-06-8

N-[1-(4-Fluorobenzyl)-4-piperidyl]-3-(2-pyrimidinylamino)benzamide1435981-06-8C₂₃H₂₄FN₅O

N-(2-(Cyclohex-1-en-1-yl)ethyl)-1-(2-fluorobenzyl)-5-(pyridin-4-yl)-1H-1,2,3-triazole-4-carboxamide chemical structure, C23H24FN5O, CAS 2034248-59-2

N-(2-(Cyclohex-1-en-1-yl)ethyl)-1-(2-fluorobenzyl)-5-(pyridin-4-yl)-1H-1,2,3-triazole-4-carboxamide2034248-59-2C₂₃H₂₄FN₅O

Frequently asked questions

Quick answers about Taletrectinib, based on the data on this page

What is Taletrectinib?

Taletrectinib is an orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration, taletrectinib binds to and inhibits ROS1 and the NTRK family members.

What is the CAS number of Taletrectinib?

The CAS registry number of Taletrectinib is 1505514-27-1. Other or deprecated CAS numbers: 1505515-69-4.

What is the molecular formula and weight of Taletrectinib?

The molecular formula of Taletrectinib is C23H24FN5O and its molar mass is 405.48 g/mol.

What is Taletrectinib used for?

Known uses and roles of Taletrectinib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, pharmaceutical, antineoplastic agents and 1 more.

Is Taletrectinib hazardous?

No GHS hazard classification for Taletrectinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Taletrectinib?

Taletrectinib is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Taletrectinib?

Post a free request on CompoundList and suppliers of Taletrectinib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Taletrectinib?

Suppliers quote Taletrectinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Taletrectinib

Taletrectinib

Key facts

What is Taletrectinib?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Taletrectinib suppliers

Taletrectinib price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

HS code and trade data

Global trade

Frequently asked questions

What is Taletrectinib?

What is the CAS number of Taletrectinib?

What is the molecular formula and weight of Taletrectinib?

What is Taletrectinib used for?

Is Taletrectinib hazardous?

What is the HS code of Taletrectinib?

Where can I buy Taletrectinib?

What is the price of Taletrectinib?

Guides for buyers

Get quotes for Taletrectinib

Key facts

What is Taletrectinib?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Taletrectinib suppliers

Taletrectinib price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Same formula isomers

Frequently asked questions

What is Taletrectinib?

What is the CAS number of Taletrectinib?

What is the molecular formula and weight of Taletrectinib?

What is Taletrectinib used for?

Is Taletrectinib hazardous?

What is the HS code of Taletrectinib?

Where can I buy Taletrectinib?

What is the price of Taletrectinib?

Guides for buyers

Get quotes for Taletrectinib