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Insecticides and acaricides

Temephos

Also known as Temefos, ABATE, Difos

CAS 3383-96-8Formula C16H20O6P2S3Molar mass 466.48 g/molEC 222-191-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 25 suppliers listed
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Temephos chemical structure, C16H20O6P2S3, CAS 3383-96-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless crystals
Melting point
30 to 30.5
Boiling point
120 to 125
Density
1.3 g/cm³
Flash point
75 °C
HS code
293090
Category
Insecticides and acaricides
UN number
UN 3077
Illustrative photo, colourless crystals in an open woven sack in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Temephos?

Plain description, key identifiers and synonyms

Temephos is an organic sulfide that is diphenyl sulfide in which the hydrogen at the para position of each of the phenyl groups has been replaced by a (dimethoxyphosphorothioyl)oxy group. It has a role as an acaricide, an agrochemical, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an ectoparasiticide. It is an organic sulfide, an organothiophosphate insecticide and an organic thiophosphate. It is functionally related to a 4,4'-thiodiphenol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[4-(4-dimethoxyphosphinothioyloxyphenyl)sulfanylphenoxy]-dimethoxy-sulfanylidene-λ5-phosphane
CAS number
3383-96-8 CAS number cross-checked
EC number
222-191-1
Molecular formula
C16H20O6P2S3
UNII
ONP3ME32DL
MDL number
MFCD00128034
InChIKey
WWJZWCUNLNYYAU-UHFFFAOYSA-N
InChI
InChI=1S/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3
SMILES (canonical and isomeric)
COP(=S)(OC)OC1=CC=C(C=C1)SC2=CC=C(C=C2)OP(=S)(OC)OC

Synonyms

  • Temefos
  • ABATE
  • Difos
  • Difenphos
  • Abathion
  • Biothion
  • Procida
  • Nephis
  • Bithion
  • Nephis 1G
  • Nimitex
  • Nimitox
  • Swebate
  • Ecopro 1707
  • Lypor
  • Diphos (pesticide)
  • Tetrafenphos
  • Abaphos
  • Biothon
  • Swebat
  • Experimental insecticide 52160
  • Lavifos
  • Temefosum
  • Azai-ss
  • American cyanamid CL-52160
Show all 39 synonyms
  • American cyanamid AC 52,160
  • American cyanamid E.I. 52,160
  • Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester
  • ENT 27,165
  • O,O'-(Thiodi-p-phenylene) O,O,O',O'-tetramethyl bis(phosphorothioate)
  • OMS 786
  • AC 52160
  • EI 52160
  • O,O,O',O'-Tetramethyl O,O'-thiodi-P-phenylene bis(phosphorothioate)
  • O,O'-(Thiodi-4,1-phenylene)bis(O,O-dimethyl phosphorothioate)
  • O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene diphosphorothioate
  • O,O-Dimethyl phosphorothioate O,O-diester with 4,4'-thiodiphenol
  • Phenol, 4,4'-thiodi-, O,O-diester with O,O-dimethyl phosphorothioate
  • Bis-p-(O,O-dimethyl O-phenylphosphorothioate)sulfide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystalsexp.
Melting point
30 to 30.5exp.
Boiling point
120 to 125exp.
Density
1.3 g/cm³exp.
Flash point
75 °Cexp.
Solubility
In water, 9.0 × 10⁻⁶ g/L at 10 °C, 2.7 × 10⁻⁴ g/L at 20 °C, 7.0 × 10⁻⁴ g/L at 30 °Cexp.
Vapour pressure
Vapor pressure at 25 °C: negligibleexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
466.48 g/molcalc.
Exact mass
465.9897 Dacalc.
LogP (octanol/water)
5.63calc.
Topological polar surface area
55.38 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
10calc.
Heavy atoms
27calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Sc2ccccc2)cc1

c1ccc(Sc2ccccc2)cc1

2 rings, 13 atoms, the Diphenyl sulfide ring system.

1,872 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H311Toxic in contact with skin.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (21)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3077
Transport hazard class
6.1
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Temephos suppliers

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All 25 suppliers
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Where suppliers are based

25 suppliers in 5 countries

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Temephos price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Larvicide for mosquitoes, black flies, and midges and in other applications.

Effective in controlling fleas on dogs and cats and lice on humans. On crops, it is effective in controlling cutworms, thrips on citrus, and lygus bugs.

Control of "river blindness" (onchoceraiasis) ... by killing the insect vector (black fly) carrying filaria of this disease.

Use classes: Insecticides.

Pharmacological actions

  • Insecticides

Roles

  • acaricide
  • agrochemical
  • antiinfective agent
  • antiparasitic agent
  • ectoparasiticide
  • enzyme inhibitor
  • pesticide
  • pharmaceutical

Functional uses

  • Biocide

How it is made

Reaction of 4,4'-thiodiphenol and o,o-dimethyl phosphorochloridothioate

Preparation: J. B. Lovell, R. W. Baer, BE 648531 C.C. 63, 11433e (1965), eidem, US 3317636 (1964, 1967 both to American Cyanamid).

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Temephos is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Temephos is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Temephos, based on the data on this page

What is Temephos?

Temephos is an organic sulfide that is diphenyl sulfide in which the hydrogen at the para position of each of the phenyl groups has been replaced by a (dimethoxyphosphorothioyl)oxy group. It has a role as an acaricide, an agrochemical, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an ectoparasiticide.

What is the CAS number of Temephos?

The CAS registry number of Temephos is 3383-96-8.

What is the molecular formula and weight of Temephos?

The molecular formula of Temephos is C16H20O6P2S3 and its molar mass is 466.48 g/mol.

What is Temephos used for?

Larvicide for mosquitoes, black flies, and midges and in other applications. Effective in controlling fleas on dogs and cats and lice on humans. On crops, it is effective in controlling cutworms, thrips on citrus, and lygus bugs. Control of "river blindness" (onchoceraiasis) ...

Is Temephos hazardous?

Temephos carries the GHS signal word "Danger". Main hazards: harmful if swallowed, toxic in contact with skin, harmful in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Temephos?

Temephos is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Temephos?

CompoundList lists 25 suppliers of Temephos in China, India, United States, Hong Kong and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Temephos in India?

8 suppliers in India list Temephos on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Temephos?

Suppliers quote Temephos on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Temephos

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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