CompoundList
Sign in
Impurities and reference standards

Teniposide

Also known as Vumon, Vehem, Teniposido

CAS 29767-20-2Formula C32H32O13SMolar mass 656.66 g/molEC 249-831-2
GHS signal word: Danger. Pictograms: Serious health hazard 38 suppliers listed
Get quotes Compare 38 suppliers
Teniposide chemical structure, C32H32O13S, CAS 29767-20-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from absolute ethanol
Melting point
242 to 246
Solubility
Practically insoluble in water.
HS code
293890
Category
Impurities and reference standards
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Teniposide?

Plain description, key identifiers and synonyms

Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
CAS number
29767-20-2 CAS number cross-checked
EC number
249-831-2
Molecular formula
C32H32O13S
UNII
957E6438QA
MDL number
MFCD00866516
InChIKey
NRUKOCRGYNPUPR-QBPJDGROSA-N
InChI
InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1
Canonical SMILES
COc1cc(C2c3cc4c(cc3C(OC3OC5COC(c6cccs6)OC5C(O)C3O)C3COC(=O)C23)OCO4)cc(OC)c1O
Isomeric SMILES
COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)CO[C@H](O7)C8=CC=CS8)O)O

Synonyms

  • Vumon
  • Vehem
  • Teniposido
  • VM 26
  • Epidophyllotoxin
  • 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)
  • 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside)
  • 4'-Demethylepipodophyllotoxin-beta-D-thenylidine glucoside
  • Demethyl Epipodophyllotoxin Thenylidine Glucoside
  • Thenylidene Lignan
  • 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside
  • Teniposidum
  • Vee M-26
  • Teniposide (Vumon)
  • Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)
  • 4'-Dimethyl-9-(4,6-O-2-thenyid)-epipodophyllotoxin
  • 4'-Demethyl-epipodophyllotoxin-beta-D-thenylidene-glucoside
  • Teniposide (Standard)
  • Teniposide Impurity 2
  • Epipodophyllotoxin-beta-D-thenylidene-glucoside, 4'-demethyl-
  • 4'-Demethyl 1-O-(4,6-O,O-(2-thenylidene)-beta-D-glucopyranosyl)epipodophyllotoxin
  • Teniposide - Bio-X trade mark

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from absolute ethanolexp.
Melting point
242 to 246exp.
Solubility
Practically insoluble in water.exp.
Vapour pressure
6.8 × 10⁻²⁶ mm Hg at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
656.66 g/molcalc.
Exact mass
656.1564 Dacalc.
LogP (octanol/water)
2.75calc.
Topological polar surface area
160.8 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
14calc.
Rotatable bonds
6calc.
Heavy atoms
46calc.
Rings
8calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.47calc.
Formal charge
0calc.
Stereocentres
10calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OCC2C(OC3CCC4OC(c5cccs5)OCC4O3)c3cc4c(cc3C(c3ccccc3)C12)OCO4

O=C1OCC2C(OC3CCC4OC(c5cccs5)OCC4O3)c3cc4c(cc3C(c3ccccc3)C12)OCO4

8 rings, 39 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H350May cause cancer.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Teniposide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 38 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

38 suppliers in 12 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Teniposide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Antineoplastic.

Pharmacological actions

  • Antineoplastic Agents
  • Topoisomerase II Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical
  • topoisomerase inhibitor

Pharmacology

Teniposide is a Topoisomerase Inhibitor. The mechanism of action of teniposide is as a Topoisomerase Inhibitor.

How it is made

Teniposide is prepared from etoposide by reaction with 2-thiophene carboxaldehyde, with zinc chloride as the catalyst.

Semisenthythic glycoside derivative of podophyllotoxin.

Preparation: A. Von Wartburg, ZA 6607585, C. Keeler-Juslen et al, US 3524844 (1968, 1970 both to Sandoz

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Teniposide is traded under.

HS 2938.90Indicative HS code

Natural or reproduced by synthesis, other than rutoside (rutin) and its derivatives

World exports in 2024
$1.4B
−8.3% vs 2023, imports $1.35B
2019 to 2024
Top exporters
  1. China49.2%
  2. France * partner reported8.9%
  3. Malaysia6.1%
Top importers
  1. United States22.3%
  2. India * partner reported7.8%
  3. Brazil5.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Teniposide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Teniposide, based on the data on this page

What is Teniposide?

Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity.

What is the CAS number of Teniposide?

The CAS registry number of Teniposide is 29767-20-2.

What is the molecular formula and weight of Teniposide?

The molecular formula of Teniposide is C32H32O13S and its molar mass is 656.66 g/mol.

What is Teniposide used for?

Antineoplastic.

Is Teniposide hazardous?

Teniposide carries the GHS signal word "Danger". Main hazards: may cause cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Teniposide?

Teniposide is usually classified under HS code 293890 (Glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Teniposide?

CompoundList lists 38 suppliers of Teniposide in United States, China, Germany, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Teniposide?

Suppliers quote Teniposide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Teniposide

Get quotes for Teniposide

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Teniposide
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Teniposide with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/teniposide-29767-20-2" title="Teniposide structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Impurities and reference standards or HS code 293890

38 suppliers
Free quotes, contact stays private
Get quotes