Tilorone (CAS 27591-97-5): price, suppliers and safety

What is Tilorone?

Plain description, key identifiers and synonyms

Tilorone is a member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug. It has a role as an antiviral agent, an antineoplastic agent, an interferon inducer, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nicotinic acetylcholine receptor agonist and an anti-inflammatory agent. It is a member of fluoren-9-ones, an aromatic ether, a diether and a tertiary amino compound. It is a conjugate base of a tilorone(2+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
CAS number: 27591-97-5 CAS number cross-checkedOther or deprecated CAS: 27591-69-1
Molecular formula: C₂₅H₃₄N₂O₃
UNII: O6W7VEW6KS
MDL number: MFCD00866953
InChIKey: MPMFCABZENCRHV-UHFFFAOYSA-N
InChI: InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3
SMILES (canonical and isomeric): CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC

Synonyms

Bis-DEAE-fluorenone
Tilorona
Tiloronum
9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-
2,7-Bis(2-(diethylamino)ethoxy)-9H-fluoren-9-one
2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-
Bis DEAE Fluorenone
2,7-Bis-(2-diethylamino-ethoxy)-fluoren-9-one
2,7-Bis-DEAE-fluorenone
2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
Amixin IC
DEAE-F
RMI 10008DA
2,7-Bis(2-diethylaminoethoxy)fluoren-9-one dihydrochloride
2,7-bis(2-diethylaminoethyloxy)fluoren-9-one
2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone
Tiloron (*dihydrochloride*)
Tilorone hydrochloride(USAN)
DivK1c_000018
RMI 10008DA (*dihydrochloride*)
Bis-DEAE-fluorenone (*dihydrochloride*)
2, {7-Bis[2-(diethylamino)ethoxy]fluoren-9-one} dihydrochloride
9H-Fluoren-9-one, {2,7-bis[2-(diethylamino)ethoxy]-,} dihydrochloride
Fluoren-9-one, 2, {7-bis[2-(diethylamino)ethoxy]-,} dihydrochloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	410.56 g/molcalc.
Exact mass	410.2569 Dacalc.
LogP (octanol/water)	4.34calc.
Topological polar surface area	42.01 Å²calc.
Hydrogen bond donors	0calc.
Hydrogen bond acceptors	5calc.
Rotatable bonds	12calc.
Heavy atoms	30calc.
Rings	3calc.
Aromatic rings	2calc.
Fraction sp3 carbons	0.48calc.
Formal charge	0calc.
Stereocentres	0calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=C1c2ccccc2-c2ccccc21

3 rings, 14 atoms, the Fluorenone ring system.

595 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Tilorone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

1st Scientific LLC
China, NanjingUnclaimed profile
TiloroneGrade, purity and minimum order on request
Price on request
View
Hunan Chemfish Pharmaceutical Co., Ltd.
China, ChangshaUnclaimed profile
TiloroneGrade, purity and minimum order on request
Price on request
View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 1 country

China2

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Tilorone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

Anti-Inflammatory Agents
Antineoplastic Agents
Antiviral Agents
Interferon Inducers

Roles

anti-inflammatory agent
antimicrobial agent
antineoplastic agent
antiviral agent
cholinergic agonist
cholinergic drug
enzyme inhibitor
interferon inducer
neurotransmitter agent
nicotinic acetylcholine receptor agonist
pharmaceutical

Pharmacology

Tilorone is a orally available small molecule interferon inducer that is used as an antiviral agent.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tilorone is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024

$3.29B

−5.9% vs 2023, imports $3.19B

2019 to 2024

Top exporters

China39.2%
United Kingdom27.1%
India * partner reported4.8%

Top importers

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tilorone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Tilorone hydrochloride chemical structure, C25H36Cl2N2O3, CAS 27591-69-1

Tilorone hydrochloride27591-69-1C₂₅H₃₆Cl₂N₂O₃21 suppliers

Same formula isomers

Different compounds that share this molecular formula

All isomers

2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-1,3-dipropyl-, (4R,5S,6S,7R)- chemical structure, C25H34N2O3, CAS 153181-37-4

2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-1,3-dipropyl-, (4R,5S,6S,7R)-153181-37-4C₂₅H₃₄N₂O₃

2,6-Bis(morpholinomethyl)-4-(2-phenylpropan-2-yl)phenol chemical structure, C25H34N2O3, CAS 313553-45-6

2,6-Bis(morpholinomethyl)-4-(2-phenylpropan-2-yl)phenol313553-45-6C₂₅H₃₄N₂O₃

N-[2-(Cyclohex-1-en-1-yl)ethyl]-2'-(2-methoxyethyl)-1'-oxo-1',4'-dihydro-2'H-spiro[cyclopentane-1,3'-isoquinoline]-4'-carboxamide chemical structure, C25H34N2O3, CAS 1246036-18-9

N-[2-(Cyclohex-1-en-1-yl)ethyl]-2'-(2-methoxyethyl)-1'-oxo-1',4'-dihydro-2'H-spiro[cyclopentane-1,3'-isoquinoline]-4'-carboxamide1246036-18-9C₂₅H₃₄N₂O₃

N-(3,3-Dimethyl-4-oxo-5-propyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl)adamantane-1-carboxamide chemical structure, C25H34N2O3, CAS 921794-94-7

N-(3,3-Dimethyl-4-oxo-5-propyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl)adamantane-1-carboxamide921794-94-7C₂₅H₃₄N₂O₃

N-((1-((2,5-Dimethylfuran-3-yl)methyl)piperidin-4-yl)methyl)-4-phenyltetrahydro-2H-pyran-4-carboxamide chemical structure, C25H34N2O3, CAS 1234938-98-7

N-((1-((2,5-Dimethylfuran-3-yl)methyl)piperidin-4-yl)methyl)-4-phenyltetrahydro-2H-pyran-4-carboxamide1234938-98-7C₂₅H₃₄N₂O₃

1-(4-{2-Hydroxy-3-[4-(2,4,6-trimethylphenyl)piperazin-1-yl]propoxy}phenyl)propan-1-one chemical structure, C25H34N2O3, CAS 868212-96-8

1-(4-{2-Hydroxy-3-[4-(2,4,6-trimethylphenyl)piperazin-1-yl]propoxy}phenyl)propan-1-one868212-96-8C₂₅H₃₄N₂O₃

4-Methoxy-N-[(1R)-2-[[1-(1-methylethyl)-4-piperidinyl]methoxy]-1-phenylethyl]benzamide chemical structure, C25H34N2O3, CAS 785048-62-6

4-Methoxy-N-[(1R)-2-[[1-(1-methylethyl)-4-piperidinyl]methoxy]-1-phenylethyl]benzamide785048-62-6C₂₅H₃₄N₂O₃

Ethyl 4-[4-(diethylamino)phenyl]-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate chemical structure, C25H34N2O3, CAS 299449-67-5

Ethyl 4-[4-(diethylamino)phenyl]-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate299449-67-5C₂₅H₃₄N₂O₃

1-(4-Hexoxyphenoxy)-3-(2-propylbenzimidazol-1-yl)propan-2-ol chemical structure, C25H34N2O3, CAS 337499-99-7

1-(4-Hexoxyphenoxy)-3-(2-propylbenzimidazol-1-yl)propan-2-ol337499-99-7C₂₅H₃₄N₂O₃

tert-Butyl 4-[(dibenzylamino)methyl]-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate chemical structure, C25H34N2O3, CAS 1192263-81-2

tert-Butyl 4-[(dibenzylamino)methyl]-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate1192263-81-2C₂₅H₃₄N₂O₃

N'-(3,5-Dimethylbenzoyl)-N'-(2,2-dimethylpentan-3-yl)-3-methoxy-2-methylbenzohydrazide chemical structure, C25H34N2O3, CAS 755013-53-7

N'-(3,5-Dimethylbenzoyl)-N'-(2,2-dimethylpentan-3-yl)-3-methoxy-2-methylbenzohydrazide755013-53-7C₂₅H₃₄N₂O₃

2,3-Dicyano-4-(pentyloxy)phenyl 4-pentylcyclohexanecarboxylate chemical structure, C25H34N2O3, CAS 75941-52-5

2,3-Dicyano-4-(pentyloxy)phenyl 4-pentylcyclohexanecarboxylate75941-52-5C₂₅H₃₄N₂O₃

Frequently asked questions

Quick answers about Tilorone, based on the data on this page

What is Tilorone?

Tilorone is a member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.

What is the CAS number of Tilorone?

The CAS registry number of Tilorone is 27591-97-5. Other or deprecated CAS numbers: 27591-69-1.

What is the molecular formula and weight of Tilorone?

The molecular formula of Tilorone is C25H34N2O3 and its molar mass is 410.56 g/mol.

What is Tilorone used for?

Known uses and roles of Tilorone include building blocks in research and laboratory, screening compounds in research and laboratory, anti-inflammatory agent, antimicrobial agent, antineoplastic agent and 12 more.

Is Tilorone hazardous?

No GHS hazard classification for Tilorone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Tilorone?

Tilorone is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tilorone?

CompoundList lists 2 suppliers of Tilorone in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tilorone?

Suppliers quote Tilorone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tilorone

Tilorone

Key facts

What is Tilorone?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Tilorone suppliers

Where suppliers are based

Send one request to many suppliers

Tilorone price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

HS code and trade data

Global trade

Frequently asked questions

What is Tilorone?

What is the CAS number of Tilorone?

What is the molecular formula and weight of Tilorone?

What is Tilorone used for?

Is Tilorone hazardous?

What is the HS code of Tilorone?

Where can I buy Tilorone?

What is the price of Tilorone?

Guides for buyers

Get quotes for Tilorone

Key facts

What is Tilorone?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Tilorone suppliers

Where suppliers are based

Send one request to many suppliers

Tilorone price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Same formula isomers

Frequently asked questions

What is Tilorone?

What is the CAS number of Tilorone?

What is the molecular formula and weight of Tilorone?

What is Tilorone used for?

Is Tilorone hazardous?

What is the HS code of Tilorone?

Where can I buy Tilorone?

What is the price of Tilorone?

Guides for buyers

Get quotes for Tilorone