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Aromatic building blocks

Tolbutamide

Also known as Diabetamid, Arkozal, Butamide

CAS 64-77-7Formula C12H18N2O3SMolar mass 270.35 g/molEC 200-594-3
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 91 suppliers listed
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Tolbutamide chemical structure, C12H18N2O3S, CAS 64-77-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White or practically white crystalline powder
Melting point
128.5 to 129.5
Density
1.245 g/cm³ @ 25 °C
Solubility
SOL IN ALC & CHLOROFORM, FREELY SOL IN WATER, VERY SLIGHTLY SOL IN ETHER /SODIUM SALT/
HS code
293590
Category
Aromatic building blocks
Illustrative photo, off-white crystalline powder in an HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Tolbutamide?

Plain description, key identifiers and synonyms

Tolbutamide is an N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position. It has a role as a hypoglycemic agent, a potassium channel blocker, a human metabolite and an insulin secretagogue.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-butyl-3-(4-methylphenyl)sulfonylurea
CAS number
64-77-7 CAS number cross-checked
EC number
200-594-3
Molecular formula
C12H18N2O3S
UNII
982XCM1FOI
MDL number
MFCD00027169
InChIKey
JLRGJRBPOGGCBT-UHFFFAOYSA-N
InChI
InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
SMILES (canonical and isomeric)
CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Synonyms

  • Diabetamid
  • Arkozal
  • Butamide
  • Willbutamide
  • Artosin
  • Ipoglicone
  • Rastinon
  • 1-Butyl-3-(p-tolylsulfonyl)urea
  • 1-Butyl-3-tosylurea
  • Diabetol
  • Diabuton
  • Glyconon
  • Tolbutamid
  • Aglicid
  • Diaben
  • Dolipol
  • Mobenol
  • Orabet
  • Oterben
  • Tolumid
  • Artozin
  • Butamid
  • Pramidex
  • Tolbusal
  • Toluina
Show all 39 synonyms
  • Toluvan
  • Tolylsulfonylbutylurea
  • Drabet
  • Oralin
  • Orezan
  • Orinaz
  • Tolbutamidum
  • Tolbutamida
  • Sk-tolbutamide
  • N-n-Butyl-N'-tosylurea
  • N-(Butylcarbamoyl)-4-methylbenzenesulfonamide
  • 1-p-Toluenesulfonyl-3-butylurea
  • 1-Butyl-3-(p-methylphenylsulfonyl)urea
  • 1-butyl-3-(4-methylphenyl)sulfonylurea

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White or practically white crystalline powderexp.
Melting point
128.5 to 129.5exp.
Density
1.245 g/cm³ @ 25 °Cexp.
Solubility
SOL IN ALC & CHLOROFORM, FREELY SOL IN WATER, VERY SLIGHTLY SOL IN ETHER /SODIUM SALT/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
270.35 g/molcalc.
Exact mass
270.1038 Dacalc.
LogP (octanol/water)
1.78calc.
Topological polar surface area
75.27 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H361Suspected of damaging fertility or the unborn child.
  • H370Causes damage to organs.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tolbutamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 91 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

91 suppliers in 14 countries

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Tolbutamide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antidiabetic.

Therapeutic category (veterinary): Hypoglycemic agent.

An orally effective hypoglycemic drug.

Pharmacological actions

  • Hypoglycemic Agents

Roles

  • analgesic
  • animal metabolite
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • biophysical role
  • eukaryotic metabolite
  • human metabolite
  • hypoglycemic agent
  • insulin secretagogue
  • mammalian metabolite
  • membrane transport modulator
  • metabolite
  • pharmaceutical
  • potassium channel blocker
  • potassium channel modulator
  • secretagogue

Pharmacology

Tolbutamide is a Sulfonylurea.

How it is made

From butyl isocyanate & 4-toluenesulfonamide sodium...

British patent 808,071 and Aumuller, Herr, German patent 1,066,575 (both 1959 to Hoechst), Ruschig et al, US patent 2,968,158 (1961 to Upjohn).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Tolbutamide (INN), Ref no: 65, Annex ref: II/65

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tolbutamide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tolbutamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tolbutamide, based on the data on this page

What is Tolbutamide?

Tolbutamide is an N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position. It has a role as a hypoglycemic agent, a potassium channel blocker, a human metabolite and an insulin secretagogue.

What is the CAS number of Tolbutamide?

The CAS registry number of Tolbutamide is 64-77-7.

What is the molecular formula and weight of Tolbutamide?

The molecular formula of Tolbutamide is C12H18N2O3S and its molar mass is 270.35 g/mol.

What is Tolbutamide used for?

Therapeutic category: Antidiabetic. Therapeutic category (veterinary): Hypoglycemic agent. An orally effective hypoglycemic drug.

Is Tolbutamide hazardous?

Tolbutamide carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tolbutamide?

Tolbutamide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tolbutamide?

CompoundList lists 91 suppliers of Tolbutamide in United States, China, Germany, United Kingdom and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Tolbutamide in India?

3 suppliers in India list Tolbutamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Tolbutamide?

Suppliers quote Tolbutamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tolbutamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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