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Flavonoids and polyphenols

Tp-1287

Also known as Alvocidib Prodrug TP-1287, 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-7-(phosphonooxy)-, 2-(2-Chlorophenyl)-5-hydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4-oxo-4H-chromen-7-yl dihydrogen phosphate

CAS 2044686-42-0Formula C21H21ClNO8PMolar mass 481.83 g/mol
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Tp-1287 chemical structure, C21H21ClNO8P, CAS 2044686-42-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2044686-42-0
Formula
C21H21ClNO8P
Molar mass
481.83 g/mol
HS code
293499
Category
Flavonoids and polyphenols

What is Tp-1287?

Plain description, key identifiers and synonyms

Alvocidib Prodrug TP-1287 is an orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity. Upon administration of the phosphate prodrug TP-1287, the prodrug is enzymatically cleaved at the tumor site and the active moiety alvocidib is released. Alvocidib targets and binds to CDK9, thereby reducing the expression of CDK9 target genes such as the anti-apoptotic protein MCL-1, and inducing G1 cell cycle arrest and apoptosis in CDK9-overexpressing cancer cells.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4-oxochromen-7-yl] dihydrogen phosphate
CAS number
2044686-42-0
Molecular formula
C21H21ClNO8P
UNII
7MPP85IIJ3
InChIKey
YRNFLVUMZIRYKY-BLLLJJGKSA-N
InChI
InChI=1S/C21H21ClNO8P/c1-23-7-6-12(16(26)10-23)19-18(31-32(27,28)29)9-15(25)20-14(24)8-17(30-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,16,25-26H,6-7,10H2,1H3,(H2,27,28,29)/t12-,16+/m0/s1
Canonical SMILES
CN1CCC(c2c(OP(=O)(O)O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1
Isomeric SMILES
CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)OP(=O)(O)O

Synonyms

  • Alvocidib Prodrug TP-1287
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-7-(phosphonooxy)-
  • 2-(2-Chlorophenyl)-5-hydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4-oxo-4H-chromen-7-yl dihydrogen phosphate
  • Alvocidib Phosphate TP-1287
  • Alvocidib Phosphate
  • TP 1287

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
481.83 g/molcalc.
Exact mass
481.0693 Dacalc.
LogP (octanol/water)
3.07calc.
Topological polar surface area
140.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
4calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2c(C3CCNCC3)cccc12

O=c1cc(-c2ccccc2)oc2c(C3CCNCC3)cccc12

4 rings, 23 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Tp-1287 suppliers

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Tp-1287 price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tp-1287 is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Tp-1287 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tp-1287, based on the data on this page

What is Tp-1287?

Alvocidib Prodrug TP-1287 is an orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity.

What is the CAS number of Tp-1287?

The CAS registry number of Tp-1287 is 2044686-42-0.

What is the molecular formula and weight of Tp-1287?

The molecular formula of Tp-1287 is C21H21ClNO8P and its molar mass is 481.83 g/mol.

What is Tp-1287 used for?

Known uses and roles of Tp-1287 include antineoplastic agent and pharmaceutical.

Is Tp-1287 hazardous?

No GHS hazard classification for Tp-1287 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Tp-1287?

Tp-1287 is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tp-1287?

Post a free request on CompoundList and suppliers of Tp-1287 will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Tp-1287?

Suppliers quote Tp-1287 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tp-1287

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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