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Insecticides and acaricides

Trichlorfon

Also known as Metrifonate, Chlorophos, Metriphonate

CAS 52-68-6Formula C4H8Cl3O4PMolar mass 257.44 g/molEC 200-149-3
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 58 suppliers listed
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Trichlorfon chemical structure, C4H8Cl3O4P, CAS 52-68-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystals
Melting point
82.2 °C
Boiling point
100 °C
Density
1.73 g/cm³ at 20 °C
Solubility
In water, 1.20 × 10⁺⁵ mg/L at 25 °C
HS code
293154
Category
Insecticides and acaricides
UN number
UN 2783
Illustrative photo, colourless crystals in an open woven sack in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Trichlorfon?

Plain description, key identifiers and synonyms

Trichlorfon is a phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group. It has a role as an insecticide, an agrochemical, an anthelminthic drug, an EC 3.1.1.8 (cholinesterase) inhibitor and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is an organochlorine compound, an organic phosphonate and a phosphonic ester.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,2,2-trichloro-1-dimethoxyphosphorylethanol
CAS number
52-68-6 CAS number cross-checkedOther or deprecated CAS: 26373-97-7, 56042-26-3, 56042-27-4
EC number
200-149-3
Molecular formula
C4H8Cl3O4P
UNII
1MVY4KU98F, 37VCQ9C0OG, DBF2DG4G2K
MDL number
MFCD00055272
InChIKey
NFACJZMKEDPNKN-UHFFFAOYSA-N
InChI
InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
SMILES (canonical and isomeric)
COP(=O)(C(C(Cl)(Cl)Cl)O)OC

Synonyms

  • Metrifonate
  • Chlorophos
  • Metriphonate
  • Trichlorphon
  • Methyl chlorophos
  • Chlorofos
  • Trichlorofon
  • Dylox
  • Chloroxyphos
  • Trichlorophon
  • Bilarcil
  • Chloroftalm
  • Dipterex
  • Foschlor
  • Anthon
  • Combot
  • Proxol
  • Danex
  • Dyrex
  • Tugon
  • DETF
  • Chlorophthalm
  • Fliegenteller
  • Agroforotox
  • Diptevur
Show all 39 synonyms
  • Ditrifon
  • Hypodermacid
  • Khloroftalm
  • Metrifonatum
  • Phoschlor
  • Polfoschlor
  • Ritsifon
  • Volfartol
  • Bovinox
  • Briten
  • Briton
  • Cekufon
  • Forotox
  • Loisol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystalsexp.
Odour
Ethyl ether-likeexp.
Melting point
82.2 °Cexp.
Boiling point
100 °Cexp.
Density
1.73 g/cm³ at 20 °Cexp.
Solubility
In water, 1.20 × 10⁺⁵ mg/L at 25 °Cexp.
Vapour pressure
7.8 × 10⁻⁶ mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
257.44 g/molcalc.
Exact mass
255.9226 Dacalc.
LogP (octanol/water)
2.16calc.
Topological polar surface area
55.76 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
12calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2783
Transport hazard class
6.1
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Trichlorfon suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 58 suppliers
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Where suppliers are based

58 suppliers in 15 countries

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Trichlorfon price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Anthelmintics, Cholinesterase Inhibitors, Insecticides.

Veterinary medication:.

Non-systemic insecticide with contact and stomach action. Insecticidal control in agriculture, horticulture, forestry, food storage, gardening, households, and animal husbandry. In particular, control of Diptera, Lepidoptera, Hymenoptera, Hemiptera and Coleoptera on many crops. ...Also used to control household pests, such as flies, cockroaches, fleas, bed bugs, silverfish, ants, etc., as a fly bait in farm buildings and animal houses, and for control of ectoparasites on domestic animals.

Use classes: Insecticides, Pesticides, Animal Drugs.

Pharmacological actions

  • Anthelmintics
  • Cholinesterase Inhibitors
  • Insecticides

Roles

  • agrochemical
  • anthelminthic drug
  • antiinfective agent
  • antiparasitic agent
  • enzyme inhibitor
  • insecticide
  • pesticide
  • pharmaceutical

Functional uses

  • Biocide

Pharmacology

Trichlorfon is a synthetic organochlorophosphate compound and organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a white crystalline or colorless to yellow or pink waxy solid, and exposure occurs by inhalation, ingestion, or contact.

How it is made

Reaction of dimethyl hydrogen phosphite with trichloroacetaldehyde.

Prepn: W. Lorenz, United States of America patent 2701225 (1955 to Bayer).

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-021-00-0

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trichlorfon is traded under.

HS 2931.54Exact HS code

Trichlorfon (ISO)

World exports in 2024
$2.49M
+18.6% vs 2023, imports $1.18M
2022 to 2024
Top exporters
  1. China99.5%
  2. Germany0.2%
  3. Switzerland * partner reported0.2%
Top importers
  1. Brazil28.4%
  2. Colombia26.4%
  3. Iran * partner reported14.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trichlorfon is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trichlorfon, based on the data on this page

What is Trichlorfon?

Trichlorfon is a phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.

What is the CAS number of Trichlorfon?

The CAS registry number of Trichlorfon is 52-68-6. Other or deprecated CAS numbers: 26373-97-7, 56042-26-3, 56042-27-4.

What is the molecular formula and weight of Trichlorfon?

The molecular formula of Trichlorfon is C4H8Cl3O4P and its molar mass is 257.44 g/mol.

What is Trichlorfon used for?

Anthelmintics, Cholinesterase Inhibitors, Insecticides. Veterinary medication:. Non-systemic insecticide with contact and stomach action. Insecticidal control in agriculture, horticulture, forestry, food storage, gardening, households, and animal husbandry.

Is Trichlorfon hazardous?

Trichlorfon carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause an allergic skin reaction, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Trichlorfon?

Trichlorfon is usually classified under HS code 293154 (Trichlorfon (ISO)). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trichlorfon?

CompoundList lists 58 suppliers of Trichlorfon in United States, China, Germany, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Trichlorfon in India?

2 suppliers in India list Trichlorfon on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Trichlorfon?

Suppliers quote Trichlorfon on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trichlorfon

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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