CompoundList
Sign in
Screening compounds

Truli

Also known as Lats-IN-1, N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide, LATS inhibitor 1

CAS 1424635-83-5Formula C18H14N4OSMolar mass 334.40 g/mol
1 supplier listed
Get quotes See the supplier
Truli chemical structure, C18H14N4OS, CAS 1424635-83-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1424635-83-5
Formula
C18H14N4OS
Molar mass
334.40 g/mol
HS code
293410
Category
Screening compounds

What is Truli?

Plain description, key identifiers and synonyms

TRULI is a pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine substituted by a N-(3-benzyl-1,3-thiazol-2(3H)-ylidene)carboxamide group at position 3. It is a potent and ATP-competitive inhibitor of LATS1 and LATS2 kinases, and a YAP signaling activator. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of benzenes, a member of 1,3-thiazoles, a pyrrolopyridine and an enamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(3-benzyl-1,3-thiazol-2-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
CAS number
1424635-83-5
Molecular formula
C18H14N4OS
MDL number
MFCD33402276
InChIKey
VTXBMVZVPUSAJF-UHFFFAOYSA-N
InChI
InChI=1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)
SMILES (canonical and isomeric)
C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4

Synonyms

  • Lats-IN-1
  • N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
  • LATS inhibitor 1
  • TRULI (Lats-IN-1)
  • Lats-IN-1(TRULI )?
  • N-(3-Benzyl-1,3-thiazol-2-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
  • The Rockefeller University Lats Inhibitor
  • TRULI, The Rockefeller University Lats Inhibitor
  • N-(3-Benzylthiazol-2(3H)-ylidene)-7-azaindole-3-carboxamide
  • N-(3-benzyl-1,3-thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
334.40 g/molcalc.
Exact mass
334.0888 Dacalc.
LogP (octanol/water)
3.22calc.
Topological polar surface area
63.04 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
24calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.06calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(N=c1sccn1Cc1ccccc1)c1c[nH]c2ncccc12

O=C(N=c1sccn1Cc1ccccc1)c1c[nH]c2ncccc12

4 rings, 24 atoms. This chemical is the scaffold itself.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Truli suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

See the supplier
  • Axon Medchem
    United States, RestonUnclaimed profile
    TruliGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Truli price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • enzyme inhibitor
  • protein kinase inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Truli is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Truli is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Truli, based on the data on this page

What is Truli?

TRULI is a pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine substituted by a N-(3-benzyl-1,3-thiazol-2(3H)-ylidene)carboxamide group at position 3. It is a potent and ATP-competitive inhibitor of LATS1 and LATS2 kinases, and a YAP signaling activator.

What is the CAS number of Truli?

The CAS registry number of Truli is 1424635-83-5.

What is the molecular formula and weight of Truli?

The molecular formula of Truli is C18H14N4OS and its molar mass is 334.40 g/mol.

What is Truli used for?

Known uses and roles of Truli include building blocks in research and laboratory, screening compounds in research and laboratory, enzyme inhibitor and protein kinase inhibitor.

Is Truli hazardous?

No GHS hazard classification for Truli is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Truli?

Truli is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Truli?

CompoundList lists 1 supplier of Truli in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Truli?

Suppliers quote Truli on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Truli

Get quotes for Truli

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Truli
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Truli with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/truli-1424635-83-5" title="Truli structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Screening compounds or HS code 293410

1 supplier
Free quotes, contact stays private
Get quotes