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Screening compounds

Utatrectinib

Also known as TRK Inhibitor AZD7451, Tropomyosin Receptor Kinase Inhibitor AZD7451, N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1H-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine

CAS 1079274-94-4Formula C18H19FN8OMolar mass 382.40 g/mol
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Utatrectinib chemical structure, C18H19FN8O, CAS 1079274-94-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1079274-94-4
Formula
C18H19FN8O
Molar mass
382.40 g/mol
HS code
293359
Category
Screening compounds

What is Utatrectinib?

Plain description, key identifiers and synonyms

Utatrectinib is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. Upon administration, utatrectinib binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1H-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine
CAS number
1079274-94-4
Molecular formula
C18H19FN8O
UNII
VNM956Y27V
InChIKey
AYOOGWWGECJQPI-NSHDSACASA-N
InChI
InChI=1S/C18H19FN8O/c1-10(2)28-16-6-15(25-26-16)27-9-22-13-4-5-14(24-18(13)27)23-11(3)17-20-7-12(19)8-21-17/h4-11H,1-3H3,(H,23,24)(H,25,26)/t11-/m0/s1
Canonical SMILES
CC(C)Oc1cc(-n2cnc3ccc(NC(C)c4ncc(F)cn4)nc32)[nH]n1
Isomeric SMILES
C[C@@H](C1=NC=C(C=N1)F)NC2=NC3=C(C=C2)N=CN3C4=CC(=NN4)OC(C)C

Synonyms

  • TRK Inhibitor AZD7451
  • Tropomyosin Receptor Kinase Inhibitor AZD7451
  • N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1H-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine
  • (S)-N-(1-(5-Fluoropyrimidin-2-yl)ethyl)-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine
  • N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-[5-(propan-2-yloxy)-1H-pyrazol-3-yl]-3H-imidazo[4,5-b]pyridin-5-amine
  • Example 6
  • US8486966, 6
  • N-[(1S)-1-(5-Fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
382.40 g/molcalc.
Exact mass
382.1666 Dacalc.
LogP (octanol/water)
3.03calc.
Topological polar surface area
106.4 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
6calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.28calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cnc(CNc2ccc3ncn(-c4ccn[nH]4)c3n2)nc1

c1cnc(CNc2ccc3ncn(-c4ccn[nH]4)c3n2)nc1

4 rings, 22 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Utatrectinib suppliers

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Utatrectinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Utatrectinib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Utatrectinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Utatrectinib, based on the data on this page

What is Utatrectinib?

Utatrectinib is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. Upon administration, utatrectinib binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation.

What is the CAS number of Utatrectinib?

The CAS registry number of Utatrectinib is 1079274-94-4.

What is the molecular formula and weight of Utatrectinib?

The molecular formula of Utatrectinib is C18H19FN8O and its molar mass is 382.40 g/mol.

What is Utatrectinib used for?

Known uses and roles of Utatrectinib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Utatrectinib hazardous?

No GHS hazard classification for Utatrectinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Utatrectinib?

Utatrectinib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Utatrectinib?

Post a free request on CompoundList and suppliers of Utatrectinib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Utatrectinib?

Suppliers quote Utatrectinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Utatrectinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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