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Nucleosides and nucleotides

Valopicitabine

Also known as valopicitabina, 2'-C-methylcytidine 3'-O-L-valinyl ester, 2'-C-methylcytidine 3'-O-valinyl ester

CAS 640281-90-9Formula C15H24N4O6Molar mass 356.38 g/mol
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Valopicitabine chemical structure, C15H24N4O6, CAS 640281-90-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
640281-90-9
Formula
C15H24N4O6
Molar mass
356.38 g/mol
HS code
293499
Category
Nucleosides and nucleotides

What is Valopicitabine?

Plain description, key identifiers and synonyms

Valopicitabine is the 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine, upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl] (2S)-2-amino-3-methylbutanoate
CAS number
640281-90-9 CAS number cross-checked
Molecular formula
C15H24N4O6
UNII
I2T0B5G94M
InChIKey
TVRCRTJYMVTEFS-ICGCPXGVSA-N
InChI
InChI=1S/C15H24N4O6/c1-7(2)10(17)12(21)25-11-8(6-20)24-13(15(11,3)23)19-5-4-9(16)18-14(19)22/h4-5,7-8,10-11,13,20,23H,6,17H2,1-3H3,(H2,16,18,22)/t8-,10+,11-,13-,15-/m1/s1
Canonical SMILES
CC(C)C(N)C(=O)OC1C(CO)OC(n2ccc(N)nc2=O)C1(C)O
Isomeric SMILES
CC(C)[C@@H](C(=O)O[C@@H]1[C@H](O[C@H]([C@]1(C)O)N2C=CC(=NC2=O)N)CO)N

Synonyms

  • valopicitabina
  • 2'-C-methylcytidine 3'-O-L-valinyl ester
  • 2'-C-methylcytidine 3'-O-valinyl ester
  • valopicitabinum
  • (2R,3R,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl (2S)-2-amino-3-methylbutanoate
  • [(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl] (2S)-2-amino-3-methylbutanoate
  • val-mCyd
  • Valopicitabine, >98% (HPLC)
  • 2'-C-Methyl-3'-O-L-valylcytidine
  • L-Valine, 3'-ester with 2'-C-methylcytidine
  • 2'-C-methyl-3'-O-(L-valinyl)-beta-D-cytidine
  • 2'-C-Methyl-3'-O-valinylcytidine dihydrochloride salt
  • (2R,3R,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl L-valinate
  • [(2R,3R,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyl-tetrahydrofuran-3-yl] (2S)-2-amino-3-methyl-butanoate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
356.38 g/molcalc.
Exact mass
356.1696 Dacalc.
LogP (octanol/water)
-1.64calc.
Topological polar surface area
162.9 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
5calc.
Heavy atoms
25calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ncccn1C1CCCO1

O=c1ncccn1C1CCCO1

2 rings, 12 atoms.

1,589 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Valopicitabine suppliers

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Where suppliers are based

1 supplier in 1 country

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Valopicitabine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antimicrobial agent
  • antiviral agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Valopicitabine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Valopicitabine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Valopicitabine, based on the data on this page

What is Valopicitabine?

Valopicitabine is the 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity.

What is the CAS number of Valopicitabine?

The CAS registry number of Valopicitabine is 640281-90-9.

What is the molecular formula and weight of Valopicitabine?

The molecular formula of Valopicitabine is C15H24N4O6 and its molar mass is 356.38 g/mol.

What is Valopicitabine used for?

Known uses and roles of Valopicitabine include antimicrobial agent and antiviral agent.

Is Valopicitabine hazardous?

No GHS hazard classification for Valopicitabine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Valopicitabine?

Valopicitabine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Valopicitabine?

CompoundList lists 1 supplier of Valopicitabine in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Valopicitabine?

Suppliers quote Valopicitabine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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