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Synthesis reagents

Vimseltinib

Also known as 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one, 3-methyl-5-[6-methyl-5-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxypyridin-2-yl]-2-(propan-2-ylamino)pyrimidin-4-one, compound 20

CAS 1628606-05-2Formula C23H25N7O2Molar mass 431.50 g/mol
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Vimseltinib chemical structure, C23H25N7O2, CAS 1628606-05-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1628606-05-2
Formula
C23H25N7O2
Molar mass
431.50 g/mol
HS code
293359
Category
Synthesis reagents

What is Vimseltinib?

Plain description, key identifiers and synonyms

Vimseltinib is an orally bioavailable inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R, CSF-1R, C-FMS, CD115, M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities. Upon administration, vimseltinib targets and binds to CSF1R expressed on monocytes, macrophages, and osteoclasts and inhibits the binding of the CSF1R ligands colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34), to CSF1R. This prevents CSF1R activation and CSF1R-mediated signaling in these cells. This blocks the production of inflammatory mediators by macrophages and monocytes and reduces inflammation.

Read more

By blocking the recruitment to the tumor microenvironment (TME) and activity of CSF1R-dependent tumor-associated macrophages (TAMs), vimseltinib inhibits the immunomodulating activity by macrophages and enhances T-cell infiltration and anti-tumor T-cell immune responses, which inhibits the proliferation of tumor cells. TAMs play key roles in the TME and allow for immune suppression, TAMs promote inflammation, tumor cell proliferation, angiogenesis, invasiveness and survival.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-methyl-5-[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-2-(propan-2-ylamino)pyrimidin-4-one
CAS number
1628606-05-2
Molecular formula
C23H25N7O2
UNII
PX9FTM69BF
MDL number
MFCD32858282
InChIKey
TVGAHWWPABTBCX-UHFFFAOYSA-N
InChI
InChI=1S/C23H25N7O2/c1-14(2)27-23-25-12-18(22(31)30(23)5)19-6-7-21(15(3)28-19)32-17-8-9-24-20(10-17)16-11-26-29(4)13-16/h6-14H,1-5H3,(H,25,27)
SMILES (canonical and isomeric)
CC1=C(C=CC(=N1)C2=CN=C(N(C2=O)C)NC(C)C)OC3=CC(=NC=C3)C4=CN(N=C4)C

Synonyms

  • 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one
  • 3-methyl-5-[6-methyl-5-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxypyridin-2-yl]-2-(propan-2-ylamino)pyrimidin-4-one
  • compound 20
  • example 10
  • 3-Methyl-2-((1-methylethyl)amino)-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl)oxy)-2-pyridinyl)-4(3H)-pyrimidinone
  • 4(3H)-Pyrimidinone, 3-methyl-2-((1-methylethyl)amino)-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl)oxy)-2-pyridinyl)-
  • compound 20 (PMID: 35961460)
  • example 10 (WO2014145025A2)
  • 3-methyl-5-(6-methyl-5-(2-(1-methylpyrazol-4-yl)pyridin-4-yl)oxypyridin-2-yl)-2-(propan-2-ylamino)pyrimidin-4-one
  • CSF1R Inhibitor DCC-3014
  • DCC 3014
  • Romvimza
  • Vimseltinib (USAN/INN)
  • DCC-3014(Vimseltinib)?
  • WHO 11443
  • US12582655, Example Compound 1
  • 2-(isopropylamino)-3-methyl-5-[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]-2-pyridyl]pyrimidin-4-one
  • 3-methyl-5-(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)-2-[(propan-2-yl)amino]pyrimidin-4(3H)-one
  • 3-methyl-5-[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-2-(propan-2-ylamino)pyrimidin-4-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
431.50 g/molcalc.
Exact mass
431.207 Dacalc.
LogP (octanol/water)
3.56calc.
Topological polar surface area
99.75 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
6calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]cncc1-c1ccc(Oc2ccnc(-c3cn[nH]c3)c2)cn1

O=c1[nH]cncc1-c1ccc(Oc2ccnc(-c3cn[nH]c3)c2)cn1

4 rings, 25 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Vimseltinib suppliers

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All 2 suppliers

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Where suppliers are based

2 suppliers in 2 countries

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Vimseltinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Vimseltinib is a Kinase Inhibitor. The mechanism of action of vimseltinib is as a Colony Stimulating Factor Receptor Type 1 (CSF-1R) Inhibitor, and P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor, and Organic Cation Transporter 2 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vimseltinib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vimseltinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vimseltinib, based on the data on this page

What is Vimseltinib?

Vimseltinib is an orally bioavailable inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R, CSF-1R, C-FMS, CD115, M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities.

What is the CAS number of Vimseltinib?

The CAS registry number of Vimseltinib is 1628606-05-2.

What is the molecular formula and weight of Vimseltinib?

The molecular formula of Vimseltinib is C23H25N7O2 and its molar mass is 431.50 g/mol.

What is Vimseltinib used for?

Known uses and roles of Vimseltinib include synthesis reagents in research and laboratory, antineoplastic agent and pharmaceutical.

Is Vimseltinib hazardous?

No GHS hazard classification for Vimseltinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Vimseltinib?

Vimseltinib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vimseltinib?

CompoundList lists 2 suppliers of Vimseltinib in India and Portugal. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Vimseltinib in India?

1 supplier in India list Vimseltinib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Vimseltinib?

Suppliers quote Vimseltinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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