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Peptides

Z-Devd-fmk

Also known as benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone, N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone, benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone

CAS 210344-95-9Formula C30H41FN4O12Molar mass 668.67 g/mol
6 suppliers listed
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Z-Devd-fmk chemical structure, C30H41FN4O12, CAS 210344-95-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
210344-95-9
Formula
C30H41FN4O12
Molar mass
668.67 g/mol
HS code
292429
Category
Peptides

What is Z-Devd-fmk?

Plain description, key identifiers and synonyms

Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an EC 3.4.22.56 (caspase-3) inhibitor, a neuroprotective agent and an apoptosis inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate
CAS number
210344-95-9 CAS number cross-checkedOther or deprecated CAS: 634911-78-7
Molecular formula
C30H41FN4O12
MDL number
MFCD23380217
InChIKey
GBJVAVGBSGRRKN-JYEBCORGSA-N
InChI
InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
Canonical SMILES
COC(=O)CCC(NC(=O)C(CC(=O)OC)NC(=O)OCc1ccccc1)C(=O)NC(C(=O)NC(CC(=O)OC)C(=O)CF)C(C)C
Isomeric SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Synonyms

  • benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
  • N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone
  • benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone
  • Z-Asp-Glu-Val-Asp-fluoromethyl ketone
  • Caspase-3 Inhibitor
  • Z-D(OMe)E(Ome)VD(OMe)-FMK
  • Z-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone
  • L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester
  • Z-DEVD-fluoromethylketone
  • Z-DEVD-fluoromethyl ketone
  • specific inhibitor of caspase-3
  • US9345789, Z-DEVD-FMK
  • Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-CH2F
  • benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone
  • N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl-ketone
  • Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone, >=90% (HPLC)
  • L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-|A-aspartyl-L-|A-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester
  • methyl (4S)-5-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-4-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoyl]amino}-5-oxopentanoate
  • N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
668.67 g/molcalc.
Exact mass
668.2705 Dacalc.
LogP (octanol/water)
0.01calc.
Topological polar surface area
221.6 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
12calc.
Rotatable bonds
19calc.
Heavy atoms
47calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Z-Devd-fmk suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 3 countries

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Z-Devd-fmk price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Cysteine Proteinase Inhibitors

Roles

  • apoptosis inhibitor
  • enzyme inhibitor
  • neuroprotective agent
  • pharmaceutical
  • protective agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Z-Devd-fmk is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Z-Devd-fmk is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Z-Devd-fmk, based on the data on this page

What is Z-Devd-fmk?

Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence.

What is the CAS number of Z-Devd-fmk?

The CAS registry number of Z-Devd-fmk is 210344-95-9. Other or deprecated CAS numbers: 634911-78-7.

What is the molecular formula and weight of Z-Devd-fmk?

The molecular formula of Z-Devd-fmk is C30H41FN4O12 and its molar mass is 668.67 g/mol.

What is Z-Devd-fmk used for?

Known uses and roles of Z-Devd-fmk include building blocks in research and laboratory, apoptosis inhibitor, enzyme inhibitor, neuroprotective agent, pharmaceutical and 2 more.

Is Z-Devd-fmk hazardous?

No GHS hazard classification for Z-Devd-fmk is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Z-Devd-fmk?

Z-Devd-fmk is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Z-Devd-fmk?

CompoundList lists 6 suppliers of Z-Devd-fmk in China, United States and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Z-Devd-fmk?

Suppliers quote Z-Devd-fmk on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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