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Zingerone

Also known as Vanillylacetone, 4-(4-Hydroxy-3-methoxyphenyl)butan-2-one, Zingiberone

CAS 122-48-5Formula C11H14O3Molar mass 194.23 g/molEC 204-548-3
37 suppliers listed
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Zingerone chemical structure, C11H14O3, CAS 122-48-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from acetone, petroleum ether, ether plus petroleum ether
Melting point
40.5 °C
Boiling point
187 to 188
Density
1.138-1.139 @ 25 °C
Flash point
Ca. 102
HS code
291450
Category
Flavor ingredients
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Zingerone?

Plain description, key identifiers and synonyms

Zingerone is a methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger. It has a role as an antioxidant, a flavouring agent, a fragrance, an antiemetic, a radiation protective agent, an anti-inflammatory agent and a plant metabolite. It is a monomethoxybenzene, a member of phenols and a methyl ketone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-(4-hydroxy-3-methoxyphenyl)butan-2-one
CAS number
122-48-5 CAS number cross-checked
EC number
204-548-3
Molecular formula
C11H14O3
UNII
4MMW850892
MDL number
MFCD00048232
INCI name
ZINGERONE
InChIKey
OJYLAHXKWMRDGS-UHFFFAOYSA-N
InChI
InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7,13H,3-4H2,1-2H3
SMILES (canonical and isomeric)
CC(=O)CCC1=CC(=C(C=C1)O)OC

Synonyms

  • Vanillylacetone
  • 4-(4-Hydroxy-3-methoxyphenyl)butan-2-one
  • Zingiberone
  • 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone
  • Zingherone
  • Gingerone
  • Vanillyl acetone
  • 2-Butanone, 4-(4-hydroxy-3-methoxyphenyl)-
  • [0]-Paradol
  • 4-Hydroxy-3-methoxybenzylacetone
  • 3-Methoxy-4-hydroxybenzylacetone
  • (4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone
  • (0)-Paradol
  • 4-(3-Methoxy-4-hydroxyphenyl)-2-butanone
  • 2-(4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone
  • 0 paradol
  • Vanillylacetone, Gingerone
  • 4-(4-hydroxy-3-methoxy-phenyl)-butan-2-one
  • 3-Methoxy-4-hydroxy-benzylacetone
  • (O)-Paradol
  • vanillylaceton
  • 0-paradol
  • [0]Paradol
  • Zingerone (Standard)
  • Zingerone [M+H]+
Show all 30 synonyms
  • 4-(4-hydroxy-3-methoxy-phenyl)butan-2-one
  • 4-08-00-01866 (Beilstein Handbook Reference)
  • Vanillylacetone, >=96%, FG
  • 4-(4-hydroxy-3-methoxyphenyl)-
  • Vanillylacetone, >=98%, natural, FG

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from acetone, petroleum ether, ether plus petroleum etherexp.
Odour
STRONG, PUNGENT ODOR REMINISCENT OF GINGERexp.
Taste
SHARP TASTE SIMILAR TO GINGERexp.
Melting point
40.5 °Cexp.
Boiling point
187 to 188exp.
Density
1.138-1.139 @ 25 °Cexp.
Flash point
Ca. 102exp.
Solubility
Sparingly sol in water, petroleum ether, sol in ether, dil alkaliesexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
194.23 g/molcalc.
Exact mass
194.0943 Dacalc.
LogP (octanol/water)
1.92calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
14calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Zingerone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 37 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

37 suppliers in 8 countries

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Zingerone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Flavor ingredient.

Flavoring.

Cosmetic ingredient, INCI name ZINGERONE(flavouring)

Roles

  • additive
  • anti-inflammatory agent
  • antiemetic
  • antioxidant
  • eukaryotic metabolite
  • flavouring agent
  • food additive
  • food component
  • fragrance
  • metabolite
  • pharmaceutical
  • physiological role
  • plant metabolite
  • protective agent
  • radiation protective agent

Functional uses

  • Flavouring and nutrient
  • Fragrance

Cosmetic functions

  • Flavouring

How it is made

Isolated from ginger root or prepared from vanillin and acetone followed by catalytic hydrogenation: Nomura, J Chem Soc 111, 769 (1917), Nomura, US patents 1,263,796 (1918), 1,306,710 (1919), Cotton, US patent 2,381,210 (1945 to Penn Coal Prod Co).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Zingerone is traded under.

HS 2914.50Indicative HS code

Ketone-phenols and ketones with other oxygen function

World exports in 2024
$438M
+10.9% vs 2023, imports $420M
2019 to 2024
Top exporters
  1. China50.5%
  2. India * partner reported11.6%
  3. United States11.3%
Top importers
  1. United States20.8%
  2. Germany10.0%
  3. Netherlands8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Zingerone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Zingerone, based on the data on this page

What is Zingerone?

Zingerone is a methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger.

What is the CAS number of Zingerone?

The CAS registry number of Zingerone is 122-48-5.

What is the molecular formula and weight of Zingerone?

The molecular formula of Zingerone is C11H14O3 and its molar mass is 194.23 g/mol.

What is Zingerone used for?

Flavor ingredient. Flavoring.

Is Zingerone hazardous?

No GHS hazard classification for Zingerone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Zingerone?

Zingerone is usually classified under HS code 291450 (Ketone-phenols and ketones with other oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Zingerone?

CompoundList lists 37 suppliers of Zingerone in China, United States, India, Germany and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Zingerone in India?

5 suppliers in India list Zingerone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Zingerone?

Suppliers quote Zingerone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Zingerone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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