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Central nervous system drugs

Zuclopenthixol

Also known as Clopixol, Zuclopentixol, Zuclopenthixolum

CAS 53772-83-1Formula C22H25ClN2OSMolar mass 400.98 g/molEC 258-758-5
GHS signal word: Warning. Pictograms: Harmful or irritant 10 suppliers listed
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Zuclopenthixol chemical structure, C22H25ClN2OS, CAS 53772-83-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
53772-83-1
Formula
C22H25ClN2OS
Molar mass
400.98 g/mol
EC number
258-758-5
HS code
293499
Category
Central nervous system drugs

What is Zuclopenthixol?

Plain description, key identifiers and synonyms

Clopenthixol is a thioxanthene derivative having a chloro substituent at the 2-position and an alkylidene group at the 10-position with undefined double bond stereochemistry. It has a role as an alpha-adrenergic antagonist, a H1-receptor antagonist, a serotonergic antagonist, a dopaminergic antagonist and a first generation antipsychotic. It is a primary alcohol, a N-alkylpiperazine and a member of thioxanthenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol
CAS number
53772-83-1 CAS number cross-checkedOther or deprecated CAS: 982-24-1
EC number
258-758-5
Molecular formula
C22H25ClN2OS
UNII
47ISU063SG
MDL number
MFCD00867744
InChIKey
WFPIAZLQTJBIFN-DVZOWYKESA-N
InChI
InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5-
Canonical SMILES
OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(Cl)cc32)CC1
Isomeric SMILES
C1CN(CCN1CC/C=C\2/C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

Synonyms

  • Clopixol
  • Zuclopentixol
  • Zuclopenthixolum
  • Clopentixol cis-(Z)-
  • 2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol
  • (Z)-4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol
  • 2-(4-{3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethan-1-ol
  • zuclopentixolo
  • 2-(4-((3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl)piperazin-1-yl)ethanol
  • 2-(4-(3-((9Z)-2-chloro-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethan-1-ol
  • Clopenthixol cis(z)-
  • Cisordinol
  • cis-Clopenthixol
  • Zoclopenthixol
  • Clopenthixol cis(z)-form
  • Sordinol
  • (Z)-2-(4-(3-(2-Chloro-9H-Thioxanthen-9-Ylidene)Propyl)Piperazin-1-Yl)Ethanol
  • Zuclopenthixol (INN)
  • Clopixol (TN)
  • Acuphase
  • Zuclopenthixol (1.0 mg/mL In Methanol)
  • C22H25ClN2OS
  • (Z)-2-[4-[3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol
  • cis(Z)-cloflupentixol
  • Clopenthixol (USAN)
Show all 28 synonyms
  • PS23 - Zuclopenthixol
  • Zuclopenthixol, 1mg/ml in Methanol
  • PDSP1_001122

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
400.98 g/molcalc.
Exact mass
400.1376 Dacalc.
LogP (octanol/water)
4.24calc.
Topological polar surface area
26.71 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(CCN1CCNCC1)=C1c2ccccc2Sc2ccccc21

C(CCN1CCNCC1)=C1c2ccccc2Sc2ccccc21

4 rings, 23 atoms.

67 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Zuclopenthixol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 10 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

10 suppliers in 4 countries

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Zuclopenthixol price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Roles

  • H1-receptor antagonist
  • adrenergic agent
  • adrenergic antagonist
  • alpha-adrenergic antagonist
  • alpha-adrenergic drug
  • antagonist
  • antidepressant
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Zuclopenthixol is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Zuclopenthixol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Zuclopenthixol, based on the data on this page

What is Zuclopenthixol?

Clopenthixol is a thioxanthene derivative having a chloro substituent at the 2-position and an alkylidene group at the 10-position with undefined double bond stereochemistry.

What is the CAS number of Zuclopenthixol?

The CAS registry number of Zuclopenthixol is 53772-83-1. Other or deprecated CAS numbers: 982-24-1.

What is the molecular formula and weight of Zuclopenthixol?

The molecular formula of Zuclopenthixol is C22H25ClN2OS and its molar mass is 400.98 g/mol.

What is Zuclopenthixol used for?

Use classes: Pharmaceuticals.

Is Zuclopenthixol hazardous?

Zuclopenthixol carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Zuclopenthixol?

Zuclopenthixol is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Zuclopenthixol?

CompoundList lists 10 suppliers of Zuclopenthixol in China, United States, Hong Kong and Italy. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Zuclopenthixol?

Suppliers quote Zuclopenthixol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Zuclopenthixol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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