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Murcko scaffold

4-Phenyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one scaffold

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
10
With full pages
1
Scaffold SMILES

O=c1c2ccccc2n2cnnc2n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one page
Murcko scaffold O=c1c2ccccc2n2cnnc2n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

4-Phenyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C15H10N4O, CAS 67811-46-5
4-Phenyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 67811-46-5C15H10N4O
2-[4-(4-Ethylphenyl)-5-oxo(4,10-dihydro-1,2,4-triazolo[4,3-a]quinazolinylthio)]-N-(2,2,2-trifluoroethyl)acetamide chemical structure, C21H18F3N5O2S, CAS 871216-04-5
2-[4-(4-Ethylphenyl)-5-oxo(4,10-dihydro-1,2,4-triazolo[4,3-a]quinazolinylthio)]-N-(2,2,2-trifluoroethyl)acetamide
CAS 871216-04-5C21H18F3N5O2S
8-Chloro-1-(chloromethyl)-4-(4-ethoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C18H14Cl2N4O2, CAS 855715-16-1
8-Chloro-1-(chloromethyl)-4-(4-ethoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 855715-16-1C18H14Cl2N4O2
N-(1-Cyano-1,2-dimethylpropyl)-2-{[4-(2,6-dimethylphenyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]sulfanyl}acetamide chemical structure, C25H26N6O2S, CAS 794561-86-7
N-(1-Cyano-1,2-dimethylpropyl)-2-{[4-(2,6-dimethylphenyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]sulfanyl}acetamide
CAS 794561-86-7C25H26N6O2S
4-(2-Methoxyphenyl)-1-methyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C17H14N4O2, CAS 68357-51-7
4-(2-Methoxyphenyl)-1-methyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 68357-51-7C17H14N4O2
1-(Chloromethyl)-4-(2,4-dimethylphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C18H15ClN4O, CAS 85772-39-0
1-(Chloromethyl)-4-(2,4-dimethylphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 85772-39-0C18H15ClN4O
4-(2,3-Dimethylphenyl)-1-(ethylthio)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C19H18N4OS, CAS 85772-42-5
4-(2,3-Dimethylphenyl)-1-(ethylthio)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 85772-42-5C19H18N4OS
1-(Chloromethyl)-4-phenyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C16H11ClN4O, CAS 86662-62-6
1-(Chloromethyl)-4-phenyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 86662-62-6C16H11ClN4O
N-(1-Cyano-1,2-dimethylpropyl)-2-{[4-(2-methylphenyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]sulfanyl}propanamide chemical structure, C25H26N6O2S, CAS 941151-05-9
N-(1-Cyano-1,2-dimethylpropyl)-2-{[4-(2-methylphenyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]sulfanyl}propanamide
CAS 941151-05-9C25H26N6O2S
1-[(3-Hydroxypropyl)sulfanyl]-4-(2-methoxy-5-methylphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C20H20N4O3S, CAS 1210681-44-9
1-[(3-Hydroxypropyl)sulfanyl]-4-(2-methoxy-5-methylphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 1210681-44-9C20H20N4O3S