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Murcko scaffold

Ring system with 5 rings and 28 atoms

26 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
26
With full pages
15
Scaffold SMILES

O=C(C1=CC(=O)N(c2ccon2)C1c1ccccc1)c1cc2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(c2ccon2)C1c1ccccc1)c1cc2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(2,5-dimethoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C25H20N2O7, CAS 618877-44-4
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(2,5-dimethoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 618877-44-4C25H20N2O7
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(2,3-dimethoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C25H20N2O7, CAS 618877-42-2
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(2,3-dimethoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 618877-42-2C25H20N2O7
3-Hydroxy-4-(7-methoxybenzofuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C24H18N2O6, CAS 823828-01-9
3-Hydroxy-4-(7-methoxybenzofuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-5-phenyl-1H-pyrrol-2(5H)-one
CAS 823828-01-9C24H18N2O6
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C24H18N2O5, CAS 618877-20-6
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one
CAS 618877-20-6C24H18N2O5
4-(Benzofuran-2-carbonyl)-5-(4-ethoxyphenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C25H20N2O6, CAS 618877-36-4
4-(Benzofuran-2-carbonyl)-5-(4-ethoxyphenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618877-36-4C25H20N2O6
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(3-methoxy-4-propoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C27H24N2O7, CAS 618877-46-6
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(3-methoxy-4-propoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 618877-46-6C27H24N2O7
4-(Benzofuran-2-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H15FN2O5, CAS 618877-23-9
4-(Benzofuran-2-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618877-23-9C23H15FN2O5
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C26H22N2O8, CAS 618877-47-7
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione
CAS 618877-47-7C26H22N2O8
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(4-propoxyphenyl)pyrrolidine-2,3-dione chemical structure, C26H22N2O6, CAS 618877-38-6
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(4-propoxyphenyl)pyrrolidine-2,3-dione
CAS 618877-38-6C26H22N2O6
4-(Benzo[d]furan-2-ylcarbonyl)-3-hydroxy-5-[4-(methylethyl)phenyl]-1-(5-methyl isoxazol-3-yl)-3-pyrrolin-2-one chemical structure, C26H22N2O5, CAS 618877-21-7
4-(Benzo[d]furan-2-ylcarbonyl)-3-hydroxy-5-[4-(methylethyl)phenyl]-1-(5-methyl isoxazol-3-yl)-3-pyrrolin-2-one
CAS 618877-21-7C26H22N2O5
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(3-bromophenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C23H15BrN2O5, CAS 618877-28-4
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(3-bromophenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 618877-28-4C23H15BrN2O5
4-(Benzofuran-2-carbonyl)-5-(4-fluorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H15FN2O5, CAS 618877-24-0
4-(Benzofuran-2-carbonyl)-5-(4-fluorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618877-24-0C23H15FN2O5
4-(Benzofuran-2-carbonyl)-5-(3-chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H15ClN2O5, CAS 618877-25-1
4-(Benzofuran-2-carbonyl)-5-(3-chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618877-25-1C23H15ClN2O5
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-tert-butylphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C27H24N2O5, CAS 618877-22-8
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-tert-butylphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 618877-22-8C27H24N2O5
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-bromophenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C23H15BrN2O5, CAS 618877-29-5
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-bromophenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 618877-29-5C23H15BrN2O5
4-(Benzofuran-2-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H18N2O6, CAS 618877-34-2
4-(Benzofuran-2-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618877-34-2C24H18N2O6
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C23H15N3O7, CAS 618877-30-8
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 618877-30-8C23H15N3O7
4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H15ClN2O5, CAS 618877-26-2
4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618877-26-2C23H15ClN2O5
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(3-propoxyphenyl)pyrrolidine-2,3-dione chemical structure, C26H22N2O6, CAS 618877-40-0
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(3-propoxyphenyl)pyrrolidine-2,3-dione
CAS 618877-40-0C26H22N2O6
Methyl 4-[(3E)-3-[1-benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-4,5-dioxopyrrolidin-2-yl]benzoate chemical structure, C25H18N2O7, CAS 618877-32-0
Methyl 4-[(3E)-3-[1-benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-4,5-dioxopyrrolidin-2-yl]benzoate
CAS 618877-32-0C25H18N2O7
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-[3-(prop-2-en-1-yloxy)phenyl]pyrrolidine-2,3-dione chemical structure, C26H20N2O6, CAS 618877-41-1
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-[3-(prop-2-en-1-yloxy)phenyl]pyrrolidine-2,3-dione
CAS 618877-41-1C26H20N2O6
4-(Benzofuran-2-carbonyl)-3-hydroxy-5-(2-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H18N2O6, CAS 618877-33-1
4-(Benzofuran-2-carbonyl)-3-hydroxy-5-(2-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618877-33-1C24H18N2O6
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C23H15N3O7, CAS 618877-31-9
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 618877-31-9C23H15N3O7
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C23H16N2O5, CAS 618877-19-3
4-(Benzofuran-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-phenyl-1H-pyrrol-2(5H)-one
CAS 618877-19-3C23H16N2O5