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Murcko scaffold

Ring system with 5 rings and 28 atoms

30 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
30
With full pages
1
Scaffold SMILES

O=C(C1=CC(=O)N(c2nccs2)C1c1ccccc1)c1cc2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(c2nccs2)C1c1ccccc1)c1cc2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

4-(Benzofuran-2-carbonyl)-1-(4,5-dimethylthiazol-2-yl)-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C24H18N2O4S, CAS 823827-97-0
4-(Benzofuran-2-carbonyl)-1-(4,5-dimethylthiazol-2-yl)-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one
CAS 823827-97-0C24H18N2O4S
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-methylphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C23H16N2O4S, CAS 618369-76-9
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-methylphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
CAS 618369-76-9C23H16N2O4S
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(1,3-thiazol-2-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C25H20N2O7S, CAS 618863-81-3
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-1-(1,3-thiazol-2-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione
CAS 618863-81-3C25H20N2O7S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-2-(4-fluorophenyl)-4-hydroxy-2H-pyrrol-5-one chemical structure, C25H17FN2O5S, CAS 618864-10-1
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-2-(4-fluorophenyl)-4-hydroxy-2H-pyrrol-5-one
CAS 618864-10-1C25H17FN2O5S
4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H13ClN2O4S, CAS 618369-75-8
4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one
CAS 618369-75-8C22H13ClN2O4S
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-methoxyphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C23H16N2O5S, CAS 618863-96-0
(4E)-4-[1-Benzofuran-2-yl(hydroxy)methylidene]-5-(4-methoxyphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
CAS 618863-96-0C23H16N2O5S
4-(Benzofuran-2-carbonyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H13FN2O4S, CAS 618369-80-5
4-(Benzofuran-2-carbonyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one
CAS 618369-80-5C22H13FN2O4S
4-(Benzofuran-2-carbonyl)-3-hydroxy-5-phenyl-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H14N2O4S, CAS 618369-74-7
4-(Benzofuran-2-carbonyl)-3-hydroxy-5-phenyl-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one
CAS 618369-74-7C22H14N2O4S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-4-hydroxy-2-(4-hydroxyphenyl)-2H-pyrrol-5-one chemical structure, C25H18N2O6S, CAS 618864-14-5
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-4-hydroxy-2-(4-hydroxyphenyl)-2H-pyrrol-5-one
CAS 618864-14-5C25H18N2O6S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-4-hydroxy-2-phenyl-2H-pyrrol-5-one chemical structure, C25H18N2O5S, CAS 618864-04-3
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-4-hydroxy-2-phenyl-2H-pyrrol-5-one
CAS 618864-04-3C25H18N2O5S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-4-hydroxy-2-(4-methylphenyl)-2H-pyrrol-5-one chemical structure, C26H20N2O5S, CAS 618864-06-5
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-4-hydroxy-2-(4-methylphenyl)-2H-pyrrol-5-one
CAS 618864-06-5C26H20N2O5S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-2-(3-chlorophenyl)-4-hydroxy-2H-pyrrol-5-one chemical structure, C25H17ClN2O5S, CAS 618864-44-1
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-(1-benzofuran-2-carbonyl)-2-(3-chlorophenyl)-4-hydroxy-2H-pyrrol-5-one
CAS 618864-44-1C25H17ClN2O5S
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H22N2O7S, CAS 7050-35-3
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 7050-35-3C26H22N2O7S
5-(4-Butoxyphenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H24N2O6S, CAS 7050-36-4
5-(4-Butoxyphenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 7050-36-4C27H24N2O6S
5-(3-Chlorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H15ClN2O5S, CAS 7050-37-5
5-(3-Chlorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 7050-37-5C23H15ClN2O5S
5-{3-Ethoxy-4-[(prop-2-en-1-yl)oxy]phenyl}-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C28H24N2O7S, CAS 7050-38-6
5-{3-Ethoxy-4-[(prop-2-en-1-yl)oxy]phenyl}-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 7050-38-6C28H24N2O7S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-5-(4-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H19N3O8S, CAS 7050-39-7
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-5-(4-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 7050-39-7C26H19N3O8S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-4-hydroxy-2-(4-hydroxyphenyl)-3-(7-methoxy-1-benzofuran-2-carbonyl)-2H-pyrrol-5-one chemical structure, C26H20N2O7S, CAS 7050-40-0
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-4-hydroxy-2-(4-hydroxyphenyl)-3-(7-methoxy-1-benzofuran-2-carbonyl)-2H-pyrrol-5-one
CAS 7050-40-0C26H20N2O7S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-5-(3,4-diethoxyphenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C30H28N2O8S, CAS 7050-43-3
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-5-(3,4-diethoxyphenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 7050-43-3C30H28N2O8S
Ethyl 2-[2-(3-ethoxy-4-prop-2-enoxyphenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C32H30N2O9S, CAS 7050-28-4
Ethyl 2-[2-(3-ethoxy-4-prop-2-enoxyphenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 7050-28-4C32H30N2O9S
Prop-2-enyl 2-[4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-2-(4-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C28H21N3O9S, CAS 7050-29-5
Prop-2-enyl 2-[4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-2-(4-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 7050-29-5C28H21N3O9S
Methyl 2-[2-(4-ethylphenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C28H24N2O7S, CAS 7050-20-6
Methyl 2-[2-(4-ethylphenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 7050-20-6C28H24N2O7S
Ethyl 2-[2-(4-butoxyphenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C31H30N2O8S, CAS 7050-26-2
Ethyl 2-[2-(4-butoxyphenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 7050-26-2C31H30N2O8S
Ethyl 2-[2-(3-chlorophenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C27H21ClN2O7S, CAS 7050-27-3
Ethyl 2-[2-(3-chlorophenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 7050-27-3C27H21ClN2O7S