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Murcko scaffold

Ring system with 3 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
18
With full pages
4
Scaffold SMILES

O=C(CSc1ncnc2sccc12)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ncnc2sccc12)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-(6-Ethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1-phenylethanone chemical structure, C16H14N2OS2, CAS 379252-61-6
2-(6-Ethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1-phenylethanone
CAS 379252-61-6C16H14N2OS2
1-(4-Chlorophenyl)-2-(6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone chemical structure, C16H13ClN2OS2, CAS 380351-89-3
1-(4-Chlorophenyl)-2-(6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone
CAS 380351-89-3C16H13ClN2OS2
2-((6-Ethylthieno[2,3-d]pyrimidin-4-yl)thio)-1-(4-fluorophenyl)ethanone chemical structure, C16H13FN2OS2, CAS 421578-41-8
2-((6-Ethylthieno[2,3-d]pyrimidin-4-yl)thio)-1-(4-fluorophenyl)ethanone
CAS 421578-41-8C16H13FN2OS2
1-(4-Chlorophenyl)-2-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl]ethanone chemical structure, C16H13ClN2OS2, CAS 431075-12-6
1-(4-Chlorophenyl)-2-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl]ethanone
CAS 431075-12-6C16H13ClN2OS2
2-[(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl]-1-(4-fluorophenyl)ethanone chemical structure, C16H13FN2OS2, CAS 421578-46-3
2-[(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl]-1-(4-fluorophenyl)ethanone
CAS 421578-46-3C16H13FN2OS2
2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1-phenylethanone chemical structure, C16H14N2OS2, CAS 338425-04-0
2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1-phenylethanone
CAS 338425-04-0C16H14N2OS2
1-Phenyl-2-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone chemical structure, C17H16N2OS2, CAS 626205-91-2
1-Phenyl-2-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone
CAS 626205-91-2C17H16N2OS2
1-(4-Chlorophenyl)-2-[(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)thio]ethanone chemical structure, C17H15ClN2OS2, CAS 626205-88-7
1-(4-Chlorophenyl)-2-[(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)thio]ethanone
CAS 626205-88-7C17H15ClN2OS2
1-(4-Bromophenyl)-2-((6-ethylthieno[2,3-d]pyrimidin-4-yl)thio)ethanone chemical structure, C16H13BrN2OS2, CAS 421578-40-7
1-(4-Bromophenyl)-2-((6-ethylthieno[2,3-d]pyrimidin-4-yl)thio)ethanone
CAS 421578-40-7C16H13BrN2OS2
1-(4-Bromophenyl)-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone chemical structure, C16H13BrN2OS2, CAS 431053-66-6
1-(4-Bromophenyl)-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone
CAS 431053-66-6C16H13BrN2OS2
1-(3,4-Dichlorophenyl)-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone chemical structure, C16H12Cl2N2OS2, CAS 575468-99-4
1-(3,4-Dichlorophenyl)-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanone
CAS 575468-99-4C16H12Cl2N2OS2
2-((5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)thio)-1-(p-tolyl)ethanone chemical structure, C17H16N2OS2, CAS 380333-27-7
2-((5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)thio)-1-(p-tolyl)ethanone
CAS 380333-27-7C17H16N2OS2
2-((6-Ethylthieno[2,3-d]pyrimidin-4-yl)thio)-1-(4-methoxyphenyl)ethanone chemical structure, C17H16N2O2S2, CAS 421578-39-4
2-((6-Ethylthieno[2,3-d]pyrimidin-4-yl)thio)-1-(4-methoxyphenyl)ethanone
CAS 421578-39-4C17H16N2O2S2
2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1-(4-methoxyphenyl)ethanone chemical structure, C17H16N2O2S2, CAS 6654-22-4
2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1-(4-methoxyphenyl)ethanone
CAS 6654-22-4C17H16N2O2S2
2-(6-Ethyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-1-p-tolyl-ethanone chemical structure, C17H16N2OS2, CAS 380333-29-9
2-(6-Ethyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-1-p-tolyl-ethanone
CAS 380333-29-9C17H16N2OS2
1-(4-Chlorophenyl)-2-(thieno[2,3-d]pyrimidin-4-ylsulfanyl)ethanone chemical structure, C14H9ClN2OS2, CAS 496026-83-6
1-(4-Chlorophenyl)-2-(thieno[2,3-d]pyrimidin-4-ylsulfanyl)ethanone
CAS 496026-83-6C14H9ClN2OS2
2-({6-Methylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)-1-phenylethan-1-one chemical structure, C15H12N2OS2, CAS 878696-28-7
2-({6-Methylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)-1-phenylethan-1-one
CAS 878696-28-7C15H12N2OS2
1-(4-Methoxyphenyl)-2-((6-methylthieno[2,3-d]pyrimidin-4-yl)thio)ethanone chemical structure, C16H14N2O2S2, CAS 878696-42-5
1-(4-Methoxyphenyl)-2-((6-methylthieno[2,3-d]pyrimidin-4-yl)thio)ethanone
CAS 878696-42-5C16H14N2O2S2