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Murcko scaffold

Ring system with 4 rings and 24 atoms

29 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 29
With full pages: 2

Scaffold SMILES

O=C(c1ccccc1)N1CCN(Cc2nc3ccccc3[nH]2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(c1ccccc1)N1CCN(Cc2nc3ccccc3[nH]2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

(4-Methoxyphenyl)-[4-[(1-methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]methanone chemical structure, C21H23N5O4, CAS 895828-95-2

(4-Methoxyphenyl)-[4-[(1-methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]methanone

CAS 895828-95-2C₂₁H₂₃N₅O₄

(2-Methoxyphenyl)-[4-[(1-methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]methanone chemical structure, C21H23N5O4, CAS 879566-30-0

(2-Methoxyphenyl)-[4-[(1-methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]methanone

CAS 879566-30-0C₂₁H₂₃N₅O₄

[4-[(1-Methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]-phenylmethanone chemical structure, C20H21N5O3, CAS 895841-12-0

[4-[(1-Methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]-phenylmethanone

CAS 895841-12-0C₂₀H₂₁N₅O₃

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(3-fluorophenyl)methanone chemical structure, C19H19FN4O, CAS 1170121-37-5

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(3-fluorophenyl)methanone

CAS 1170121-37-5C₁₉H₁₉FN₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(4-fluorophenyl)methanone chemical structure, C19H19FN4O, CAS 1172104-13-0

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(4-fluorophenyl)methanone

CAS 1172104-13-0C₁₉H₁₉FN₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(3,4-difluorophenyl)methanone chemical structure, C19H18F2N4O, CAS 1171630-14-0

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(3,4-difluorophenyl)methanone

CAS 1171630-14-0C₁₉H₁₈F₂N₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(4-(trifluoromethyl)phenyl)methanone chemical structure, C20H19F3N4O, CAS 1170453-96-9

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(4-(trifluoromethyl)phenyl)methanone

CAS 1170453-96-9C₂₀H₁₉F₃N₄O

4-(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazine-1-carbonyl)-N,N-dimethylbenzenesulfonamide chemical structure, C21H25N5O3S, CAS 1172235-57-2

4-(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazine-1-carbonyl)-N,N-dimethylbenzenesulfonamide

CAS 1172235-57-2C₂₁H₂₅N₅O₃S

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2,4-difluorophenyl)methanone chemical structure, C19H18F2N4O, CAS 1170498-36-8

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2,4-difluorophenyl)methanone

CAS 1170498-36-8C₁₉H₁₈F₂N₄O

4-(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazine-1-carbonyl)benzonitrile chemical structure, C20H19N5O, CAS 1170190-33-6

4-(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazine-1-carbonyl)benzonitrile

CAS 1170190-33-6C₂₀H₁₉N₅O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(m-tolyl)methanone chemical structure, C20H22N4O, CAS 1172803-39-2

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(m-tolyl)methanone

CAS 1172803-39-2C₂₀H₂₂N₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(p-tolyl)methanone chemical structure, C20H22N4O, CAS 1171468-91-9

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(p-tolyl)methanone

CAS 1171468-91-9C₂₀H₂₂N₄O

2-{[4-(2-Methoxybenzoyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole chemical structure, C20H22N4O2, CAS 1173255-27-0

2-{[4-(2-Methoxybenzoyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole

CAS 1173255-27-0C₂₀H₂₂N₄O₂

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(3-methoxyphenyl)methanone chemical structure, C20H22N4O2, CAS 1172009-35-6

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(3-methoxyphenyl)methanone

CAS 1172009-35-6C₂₀H₂₂N₄O₂

2-{[4-(4-Methoxybenzoyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole chemical structure, C20H22N4O2, CAS 1172477-25-6

2-{[4-(4-Methoxybenzoyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole

CAS 1172477-25-6C₂₀H₂₂N₄O₂

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2-chlorophenyl)methanone chemical structure, C19H19ClN4O, CAS 1171667-62-1

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2-chlorophenyl)methanone

CAS 1171667-62-1C₁₉H₁₉ClN₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2-bromophenyl)methanone chemical structure, C19H19BrN4O, CAS 1171174-42-7

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2-bromophenyl)methanone

CAS 1171174-42-7C₁₉H₁₉BrN₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2,6-difluorophenyl)methanone chemical structure, C19H18F2N4O, CAS 1171140-54-7

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2,6-difluorophenyl)methanone

CAS 1171140-54-7C₁₉H₁₈F₂N₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(5-chloro-2-methoxyphenyl)methanone chemical structure, C20H21ClN4O2, CAS 1171396-79-4

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(5-chloro-2-methoxyphenyl)methanone

CAS 1171396-79-4C₂₀H₂₁ClN₄O₂

[4-(1H-Benzimidazol-2-ylmethyl)piperazin-1-yl]-[3-(dimethylamino)phenyl]methanone chemical structure, C21H25N5O, CAS 1171027-68-1

[4-(1H-Benzimidazol-2-ylmethyl)piperazin-1-yl]-[3-(dimethylamino)phenyl]methanone

CAS 1171027-68-1C₂₁H₂₅N₅O

(2,4-Difluorophenyl)(4-((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone chemical structure, C20H20F2N4O, CAS 1171395-65-5

(2,4-Difluorophenyl)(4-((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone

CAS 1171395-65-5C₂₀H₂₀F₂N₄O

(4-(tert-Butyl)phenyl)(4-((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone chemical structure, C24H30N4O, CAS 1171028-19-5

(4-(tert-Butyl)phenyl)(4-((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone

CAS 1171028-19-5C₂₄H₃₀N₄O

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2-chloro-6-fluorophenyl)methanone chemical structure, C19H18ClFN4O, CAS 1203178-02-2

(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(2-chloro-6-fluorophenyl)methanone

CAS 1203178-02-2C₁₉H₁₈ClFN₄O

3-(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazine-1-carbonyl)benzonitrile oxalate chemical structure, C22H21N5O5, CAS 1351644-51-3

3-(4-((1H-Benzo[d]imidazol-2-yl)methyl)piperazine-1-carbonyl)benzonitrile oxalate

CAS 1351644-51-3C₂₂H₂₁N₅O₅