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Murcko scaffold

Ring system with 4 rings and 24 atoms

40 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
40
With full pages
8
Scaffold SMILES

O=C1c2ccccc2CC1CC1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1c2ccccc2CC1CC1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

Donepezil chemical structure, C24H29NO3, CAS 120014-06-4
Donepezil
CAS 120014-06-4C24H29NO3
Donepezil hydrochloride chemical structure, C24H30ClNO3, CAS 120011-70-3
Donepezil hydrochloride
CAS 120011-70-3C24H30ClNO3
(S)-Donepezil chemical structure, C24H29NO3, CAS 142057-80-5
(S)-Donepezil
CAS 142057-80-5C24H29NO3
(R)-Donepezil chemical structure, C24H29NO3, CAS 142698-19-9
(R)-Donepezil
CAS 142698-19-9C24H29NO3
2-((1-Benzylpiperidin-4-yl)methyl)-2-hydroxy-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one chemical structure, C24H29NO4, CAS 329010-67-5
2-((1-Benzylpiperidin-4-yl)methyl)-2-hydroxy-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
CAS 329010-67-5C24H29NO4
5,6-Dimethoxy-2-[1-(3-methyl-benzyl)-piperidin-4-ylmethyl]-indan-1-one chemical structure, C25H31NO3, CAS 149874-81-7
5,6-Dimethoxy-2-[1-(3-methyl-benzyl)-piperidin-4-ylmethyl]-indan-1-one
CAS 149874-81-7C25H31NO3
ER-127528 free base chemical structure, C24H27F2NO3, CAS 290308-83-7
ER-127528 free base
CAS 290308-83-7C24H27F2NO3
2-(1-Benzyl-piperidin-4-ylmethyl)-5-methoxy-indan-1-one chemical structure, C23H27NO2, CAS 120014-08-6
2-(1-Benzyl-piperidin-4-ylmethyl)-5-methoxy-indan-1-one
CAS 120014-08-6C23H27NO2
1H-Inden-1-one, 2-fluoro-2-((1-((3-fluorophenyl)methyl)-4-piperidinyl)methyl)-2,3-dihydro-5,6-dimethoxy-, hydrochloride chemical structure, C24H28ClF2NO3, CAS 290308-82-6
1H-Inden-1-one, 2-fluoro-2-((1-((3-fluorophenyl)methyl)-4-piperidinyl)methyl)-2,3-dihydro-5,6-dimethoxy-, hydrochloride
CAS 290308-82-6C24H28ClF2NO3
1-Benzyl-4-[(5,7-dimethoxy-1-oxoindan-2-yl)methyl]piperidine chemical structure, C24H29NO3, CAS 172602-69-6
1-Benzyl-4-[(5,7-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
CAS 172602-69-6C24H29NO3
1-Benzyl-4-[(6-methoxy-1-oxoindan-2-yl)methyl]piperidine chemical structure, C23H27NO2, CAS 172602-68-5
1-Benzyl-4-[(6-methoxy-1-oxoindan-2-yl)methyl]piperidine
CAS 172602-68-5C23H27NO2
5,6-Dimethoxy-2-[1-(2-methyl-benzyl)-piperidin-4-ylmethyl]-indan-1-one chemical structure, C25H31NO3, CAS 149874-80-6
5,6-Dimethoxy-2-[1-(2-methyl-benzyl)-piperidin-4-ylmethyl]-indan-1-one
CAS 149874-80-6C25H31NO3
Donepezilhcl chemical structure, C24H30ClNO3, CAS 142057-77-0
Donepezilhcl
CAS 142057-77-0C24H30ClNO3
Donepezil N-oxide chemical structure, C24H29NO4, CAS 120013-84-5
Donepezil N-oxide
CAS 120013-84-5C24H29NO4
Donepezil oxalate chemical structure, C26H31NO7, CAS 870555-76-3
Donepezil oxalate
CAS 870555-76-3C26H31NO7
5-O-Desmethyl donepezil chemical structure, C23H27NO3, CAS 120013-57-2
5-O-Desmethyl donepezil
CAS 120013-57-2C23H27NO3
Donepezil hydrochloride monohydrate chemical structure, C24H32ClNO4, CAS 884740-09-4
Donepezil hydrochloride monohydrate
CAS 884740-09-4C24H32ClNO4
1-Benzyl-4-[(6,7-dimethoxy-1-oxoindan-2-yl)methyl]piperidine chemical structure, C24H29NO3, CAS 736104-42-0
1-Benzyl-4-[(6,7-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
CAS 736104-42-0C24H29NO3
1H-Inden-1-one, 2,3-dihydro-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1) chemical structure, C23H28ClNO2, CAS 120013-48-1
1H-Inden-1-one, 2,3-dihydro-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)
CAS 120013-48-1C23H28ClNO2
5-Desmethoxy-7-methoxy Donepezil Hydrochloride chemical structure, C24H30ClNO3, CAS 120013-51-6
5-Desmethoxy-7-methoxy Donepezil Hydrochloride
CAS 120013-51-6C24H30ClNO3
6-O-Desmethyldonepezil chemical structure, C23H27NO3, CAS 120013-56-1
6-O-Desmethyldonepezil
CAS 120013-56-1C23H27NO3
6-O-Desmethyl donepezil hydrochloride chemical structure, C23H28ClNO3, CAS 852285-82-6
6-O-Desmethyl donepezil hydrochloride
CAS 852285-82-6C23H28ClNO3
Hydroxydonepezil chemical structure, C24H29NO4, CAS 197010-20-1
Hydroxydonepezil
CAS 197010-20-1C24H29NO4
5-O-Desmethyl donepezil-d5 chemical structure, C23H27NO3, CAS 1189929-21-2
5-O-Desmethyl donepezil-d5
CAS 1189929-21-2C23H27NO3