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Murcko scaffold

Ring system with 3 rings and 19 atoms

55 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
55
With full pages
16
Scaffold SMILES

O=C(C=Cc1ccc2c(c1)OCO2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccc2c(c1)OCO2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

3-(1,3-Benzodioxol-5-yl)-1-(4-bromophenyl)prop-2-en-1-one chemical structure, C16H11BrO3, CAS 36716-01-5
3-(1,3-Benzodioxol-5-yl)-1-(4-bromophenyl)prop-2-en-1-one
CAS 36716-01-5C16H11BrO3
3-Benzo[1,3]dioxol-5-YL-1-(4-fluorophenyl)prop-2-EN-1-one chemical structure, C16H11FO3
3-Benzo[1,3]dioxol-5-YL-1-(4-fluorophenyl)prop-2-EN-1-one
C16H11FO3
3'-Hydroxy-3,4-methylenedioxy chalcone chemical structure, C16H12O4, CAS 92965-03-2
3'-Hydroxy-3,4-methylenedioxy chalcone
CAS 92965-03-2C16H12O4
3,4-Methylenedioxy-2',4'-dimethoxychalcone chemical structure, C18H16O5, CAS 58344-60-8
3,4-Methylenedioxy-2',4'-dimethoxychalcone
CAS 58344-60-8C18H16O5
3-(1,3-Benzodioxol-5-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one chemical structure, C18H16O5, CAS 51116-22-4
3-(1,3-Benzodioxol-5-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one
CAS 51116-22-4C18H16O5
2-Propen-1-one, 3-(1,3-benzodiol-5-yl)-1-(4-methylphenyl)- chemical structure, C17H14O3, CAS 37620-38-5
2-Propen-1-one, 3-(1,3-benzodiol-5-yl)-1-(4-methylphenyl)-
CAS 37620-38-5C17H14O3
4'-Fluoro-3,4-(methylenedioxy)chalcone chemical structure, C16H11FO3, CAS 7397-23-1
4'-Fluoro-3,4-(methylenedioxy)chalcone
CAS 7397-23-1C16H11FO3
3-(1,3-Benzodioxol-5-yl)-1-(4-methoxyphenyl)prop-2-en-1-one chemical structure, C17H14O4, CAS 2373-93-5
3-(1,3-Benzodioxol-5-yl)-1-(4-methoxyphenyl)prop-2-en-1-one
CAS 2373-93-5C17H14O4
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(3-methoxyphenyl)prop-2-en-1-one chemical structure, C17H14O4, CAS 508169-92-4
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(3-methoxyphenyl)prop-2-en-1-one
CAS 508169-92-4C17H14O4
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(3-bromophenyl)prop-2-en-1-one chemical structure, C16H11BrO3, CAS 351339-24-7
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(3-bromophenyl)prop-2-en-1-one
CAS 351339-24-7C16H11BrO3
3-(1,3-Benzodioxol-5-yl)-1-phenyl-2-propen-1-one chemical structure, C16H12O3, CAS 644-34-8
3-(1,3-Benzodioxol-5-yl)-1-phenyl-2-propen-1-one
CAS 644-34-8C16H12O3
(E)-3-(1,3-Benzodioxol-5-yl)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)prop-2-en-1-one chemical structure, C19H18O7, CAS 78224-97-2
(E)-3-(1,3-Benzodioxol-5-yl)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)prop-2-en-1-one
CAS 78224-97-2C19H18O7
(E)-3-(1,3-Benzodioxol-5-yl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one chemical structure, C16H12O5, CAS 6962-62-5
(E)-3-(1,3-Benzodioxol-5-yl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
CAS 6962-62-5C16H12O5
(E)-3-(1,3-Benzodioxol-5-yl)-1-(3-bromo-5-fluoro-2-hydroxyphenyl)prop-2-en-1-one chemical structure, C16H10BrFO4, CAS 1893-74-9
(E)-3-(1,3-Benzodioxol-5-yl)-1-(3-bromo-5-fluoro-2-hydroxyphenyl)prop-2-en-1-one
CAS 1893-74-9C16H10BrFO4
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(4-nitrophenyl)prop-2-en-1-one chemical structure, C16H11NO5, CAS 92858-63-4
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(4-nitrophenyl)prop-2-en-1-one
CAS 92858-63-4C16H11NO5
3-(1,3-Benzodioxol-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one chemical structure, C16H11NO5, CAS 1058712-24-5
3-(1,3-Benzodioxol-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one
CAS 1058712-24-5C16H11NO5
(E)-3-(1,3-Benzodioxol-5-yl)-1-(2,4-dimethylphenyl)prop-2-en-1-one chemical structure, C18H16O3, CAS 215778-51-1
(E)-3-(1,3-Benzodioxol-5-yl)-1-(2,4-dimethylphenyl)prop-2-en-1-one
CAS 215778-51-1C18H16O3
3-(1,3-Benzodioxol-5-yl)-1-(4-hydroxyphenyl)-2-propen-1-one chemical structure, C16H12O4, CAS 19152-39-7
3-(1,3-Benzodioxol-5-yl)-1-(4-hydroxyphenyl)-2-propen-1-one
CAS 19152-39-7C16H12O4
3-(1,3-Benzodioxol-5-yl)-1-(4-chlorophenyl)prop-2-en-1-one chemical structure, C16H11ClO3, CAS 69538-64-3
3-(1,3-Benzodioxol-5-yl)-1-(4-chlorophenyl)prop-2-en-1-one
CAS 69538-64-3C16H11ClO3
2'-Hydroxy-2-piperonylideneacetophenone chemical structure, C16H12O4, CAS 16669-99-1
2'-Hydroxy-2-piperonylideneacetophenone
CAS 16669-99-1C16H12O4
3-(1,3-Benzodioxol-5-yl)-1-(2-chlorophenyl)prop-2-en-1-one chemical structure, C16H11ClO3, CAS 144017-78-7
3-(1,3-Benzodioxol-5-yl)-1-(2-chlorophenyl)prop-2-en-1-one
CAS 144017-78-7C16H11ClO3
3-(1,3-Benzodioxol-5-yl)-1-[2-nitro-4-(trifluoromethyl)phenyl]prop-2-en-1-one chemical structure, C17H10F3NO5, CAS 256525-76-5
3-(1,3-Benzodioxol-5-yl)-1-[2-nitro-4-(trifluoromethyl)phenyl]prop-2-en-1-one
CAS 256525-76-5C17H10F3NO5
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(4-ethoxyphenyl)prop-2-en-1-one chemical structure, C18H16O4, CAS 1689543-96-1
(2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(4-ethoxyphenyl)prop-2-en-1-one
CAS 1689543-96-1C18H16O4
4-[3-(1,3-Benzodioxol-5-yl)acryloyl]phenyl methanesulfonate chemical structure, C17H14O6S, CAS 331460-82-3
4-[3-(1,3-Benzodioxol-5-yl)acryloyl]phenyl methanesulfonate
CAS 331460-82-3C17H14O6S