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Murcko scaffold

Ring system with 3 rings and 19 atoms

22 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
22
With full pages
8
Scaffold SMILES

O=C(C=Cc1ccccc1)c1ccc2c(c1)OCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)c1ccc2c(c1)OCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

1-(1,3-Benzodioxol-5-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propen-1-one chemical structure, C20H20O3, CAS 423740-32-3
1-(1,3-Benzodioxol-5-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propen-1-one
CAS 423740-32-3C20H20O3
1-(1,3-Benzodioxol-5-yl)-3-(4-bromophenyl)-2-propen-1-one chemical structure, C16H11BrO3, CAS 756826-07-0
1-(1,3-Benzodioxol-5-yl)-3-(4-bromophenyl)-2-propen-1-one
CAS 756826-07-0C16H11BrO3
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one chemical structure, C18H16O5, CAS 88775-45-5
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one
CAS 88775-45-5C18H16O5
(2E)-1-(1,3-Benzodioxol-5-yl)-3-[4-(methylsulfanyl)phenyl]prop-2-en-1-one chemical structure, C17H14O3S, CAS 1575480-59-9
(2E)-1-(1,3-Benzodioxol-5-yl)-3-[4-(methylsulfanyl)phenyl]prop-2-en-1-one
CAS 1575480-59-9C17H14O3S
(E)-1-(1,3-Benzodioxol-5-yl)-3-(4-dimethylaminophenyl)prop-2-en-1-one chemical structure, C18H17NO3, CAS 928843-51-0
(E)-1-(1,3-Benzodioxol-5-yl)-3-(4-dimethylaminophenyl)prop-2-en-1-one
CAS 928843-51-0C18H17NO3
(E)-1-(1,3-Benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C19H18O6, CAS 88775-47-7
(E)-1-(1,3-Benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
CAS 88775-47-7C19H18O6
1-(1,3-Benzodioxol-5-yl)-3-(2,4-dimethoxyphenyl)-2-propen-1-one chemical structure, C18H16O5, CAS 561046-12-6
1-(1,3-Benzodioxol-5-yl)-3-(2,4-dimethoxyphenyl)-2-propen-1-one
CAS 561046-12-6C18H16O5
(E)-1-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)prop-2-en-1-one chemical structure, C16H11BrO3, CAS 1214741-15-7
(E)-1-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)prop-2-en-1-one
CAS 1214741-15-7C16H11BrO3
(E)-4-(3-(Benzo[d][1,3]dioxol-5-yl)-3-oxoprop-1-en-1-yl)benzoic acid chemical structure, C17H12O5, CAS 1014629-59-4
(E)-4-(3-(Benzo[d][1,3]dioxol-5-yl)-3-oxoprop-1-en-1-yl)benzoic acid
CAS 1014629-59-4C17H12O5
(E)-1-(1,3-Benzodioxol-5-yl)-3-(3-nitrophenyl)prop-2-en-1-one chemical structure, C16H11NO5, CAS 1252015-02-3
(E)-1-(1,3-Benzodioxol-5-yl)-3-(3-nitrophenyl)prop-2-en-1-one
CAS 1252015-02-3C16H11NO5
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(4-chlorophenyl)-2-propen-1-one chemical structure, C16H11ClO3, CAS 1045707-20-7
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(4-chlorophenyl)-2-propen-1-one
CAS 1045707-20-7C16H11ClO3
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(2,3-dimethoxyphenyl)prop-2-en-1-one chemical structure, C18H16O5, CAS 561046-14-8
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(2,3-dimethoxyphenyl)prop-2-en-1-one
CAS 561046-14-8C18H16O5
2-Propen-1-one, 1-(1,3-benzodioxol-5-yl)-3-(3,5-dimethoxyphenyl)-, (E)- chemical structure, C18H16O5, CAS 88775-46-6
2-Propen-1-one, 1-(1,3-benzodioxol-5-yl)-3-(3,5-dimethoxyphenyl)-, (E)-
CAS 88775-46-6C18H16O5
(2E)-1-(6-Amino-1,3-benzodioxol-5-yl)-3-(3-methoxyphenyl)-2-propen-1-one chemical structure, C17H15NO4, CAS 204841-35-0
(2E)-1-(6-Amino-1,3-benzodioxol-5-yl)-3-(3-methoxyphenyl)-2-propen-1-one
CAS 204841-35-0C17H15NO4
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(2-hydroxyphenyl)prop-2-en-1-one chemical structure, C16H12O4, CAS 800413-72-3
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(2-hydroxyphenyl)prop-2-en-1-one
CAS 800413-72-3C16H12O4
6'-Hydroxy-2,3,4,5,2'-pentamethoxy-3',4'-methylenedioxychalcone chemical structure, C21H22O9, CAS 121697-05-0
6'-Hydroxy-2,3,4,5,2'-pentamethoxy-3',4'-methylenedioxychalcone
CAS 121697-05-0C21H22O9
2,3,4,5,2',6'-Hexamethoxy-3',4'-methylenedioxychalcone chemical structure, C22H24O9, CAS 121697-06-1
2,3,4,5,2',6'-Hexamethoxy-3',4'-methylenedioxychalcone
CAS 121697-06-1C22H24O9
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(2,5-dimethoxyphenyl)-2-propen-1-one chemical structure, C18H16O5, CAS 1202071-78-0
(2E)-1-(1,3-Benzodioxol-5-yl)-3-(2,5-dimethoxyphenyl)-2-propen-1-one
CAS 1202071-78-0C18H16O5
Helilandin A chemical structure, C18H16O5, CAS 70185-50-1
Helilandin A
CAS 70185-50-1C18H16O5
2,2'-Dihydroxy-3,4,5,6'-tetramethoxy-3',4'-methylenedioxychalcone chemical structure, C20H20O9, CAS 121697-07-2
2,2'-Dihydroxy-3,4,5,6'-tetramethoxy-3',4'-methylenedioxychalcone
CAS 121697-07-2C20H20O9
3',4'-Methylenedioxy-2,4,6,beta-tetramethoxychalcone chemical structure, C20H20O7, CAS 622851-67-6
3',4'-Methylenedioxy-2,4,6,beta-tetramethoxychalcone
CAS 622851-67-6C20H20O7
2',4-Dihydroxy-6'-methoxy-3',4'-methylenedioxychalcone chemical structure, C17H14O6, CAS 73694-19-6
2',4-Dihydroxy-6'-methoxy-3',4'-methylenedioxychalcone
CAS 73694-19-6C17H14O6