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Murcko scaffold

Ring system with 3 rings and 19 atoms

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
36
With full pages
12
Scaffold SMILES

O=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

Urea, 1-(1,3-benzodioxol-5-yl)-3-(2,6-xylyl)- chemical structure, C16H16N2O3, CAS 102434-05-9
Urea, 1-(1,3-benzodioxol-5-yl)-3-(2,6-xylyl)-
CAS 102434-05-9C16H16N2O3
1-(1,3-Benzodioxol-5-yl)-3-(4-methoxyphenyl)urea chemical structure, C15H14N2O4, CAS 309733-23-1
1-(1,3-Benzodioxol-5-yl)-3-(4-methoxyphenyl)urea
CAS 309733-23-1C15H14N2O4
N-(1,3-Benzodioxol-5-yl)-N'-(3-chlorophenyl)urea chemical structure, C14H11ClN2O3, CAS 444286-01-5
N-(1,3-Benzodioxol-5-yl)-N'-(3-chlorophenyl)urea
CAS 444286-01-5C14H11ClN2O3
1-(1,3-Benzodioxol-5-yl)-3-(2-ethoxyphenyl)urea chemical structure, C16H16N2O4, CAS 701949-42-0
1-(1,3-Benzodioxol-5-yl)-3-(2-ethoxyphenyl)urea
CAS 701949-42-0C16H16N2O4
1-(1,3-Benzodioxol-5-yl)-3-(2,4-dichlorophenyl)urea chemical structure, C14H10Cl2N2O3, CAS 401595-74-2
1-(1,3-Benzodioxol-5-yl)-3-(2,4-dichlorophenyl)urea
CAS 401595-74-2C14H10Cl2N2O3
1-(1,3-Benzodioxol-5-yl)-3-(2,6-diethylphenyl)urea chemical structure, C18H20N2O3, CAS 701280-86-6
1-(1,3-Benzodioxol-5-yl)-3-(2,6-diethylphenyl)urea
CAS 701280-86-6C18H20N2O3
1-(1,3-Benzodioxol-5-yl)-3-(4-iodophenyl)urea chemical structure, C14H11IN2O3, CAS 708227-71-8
1-(1,3-Benzodioxol-5-yl)-3-(4-iodophenyl)urea
CAS 708227-71-8C14H11IN2O3
1-(1,3-Benzodioxol-5-yl)-3-[3-chloro-4-(difluoromethoxy)phenyl]urea chemical structure, C15H11ClF2N2O4, CAS 701282-39-5
1-(1,3-Benzodioxol-5-yl)-3-[3-chloro-4-(difluoromethoxy)phenyl]urea
CAS 701282-39-5C15H11ClF2N2O4
1-(1,3-Benzodioxol-5-yl)-3-(2,4-difluorophenyl)urea chemical structure, C14H10F2N2O3, CAS 793678-38-3
1-(1,3-Benzodioxol-5-yl)-3-(2,4-difluorophenyl)urea
CAS 793678-38-3C14H10F2N2O3
1-(1,3-Benzodioxol-5-yl)-3-(5-tert-butyl-2-methoxyphenyl)urea chemical structure, C19H22N2O4, CAS 701273-92-9
1-(1,3-Benzodioxol-5-yl)-3-(5-tert-butyl-2-methoxyphenyl)urea
CAS 701273-92-9C19H22N2O4
4-(1,3-Benzodioxol-5-ylcarbamoylamino)benzamide chemical structure, C15H13N3O4, CAS 725275-96-7
4-(1,3-Benzodioxol-5-ylcarbamoylamino)benzamide
CAS 725275-96-7C15H13N3O4
4-[(1,3-Benzodioxol-5-ylcarbamoyl)amino]benzoic acid chemical structure, C15H12N2O5, CAS 894397-10-5
4-[(1,3-Benzodioxol-5-ylcarbamoyl)amino]benzoic acid
CAS 894397-10-5C15H12N2O5
1-(1,3-Benzodioxol-5-yl)-3-(3,4-dimethylphenyl)urea chemical structure, C16H16N2O3, CAS 893343-68-5
1-(1,3-Benzodioxol-5-yl)-3-(3,4-dimethylphenyl)urea
CAS 893343-68-5C16H16N2O3
1-(1,3-Benzodioxol-5-yl)-3-(4-chloro-2-fluorophenyl)urea chemical structure, C14H10ClFN2O3, CAS 897323-25-0
1-(1,3-Benzodioxol-5-yl)-3-(4-chloro-2-fluorophenyl)urea
CAS 897323-25-0C14H10ClFN2O3
N-[4-(1,3-Benzodioxol-5-ylcarbamoylamino)phenyl]acetamide chemical structure, C16H15N3O4, CAS 896571-11-2
N-[4-(1,3-Benzodioxol-5-ylcarbamoylamino)phenyl]acetamide
CAS 896571-11-2C16H15N3O4
1-(1,3-Benzodioxol-5-yl)-3-(4-ethylphenyl)urea chemical structure, C16H16N2O3, CAS 893344-87-1
1-(1,3-Benzodioxol-5-yl)-3-(4-ethylphenyl)urea
CAS 893344-87-1C16H16N2O3
1-(1,3-Benzodioxol-5-yl)-3-(2-methylsulfanylphenyl)urea chemical structure, C15H14N2O3S, CAS 894261-32-6
1-(1,3-Benzodioxol-5-yl)-3-(2-methylsulfanylphenyl)urea
CAS 894261-32-6C15H14N2O3S
1-(1,3-Benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)urea chemical structure, C17H18N2O6, CAS 894226-83-6
1-(1,3-Benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)urea
CAS 894226-83-6C17H18N2O6
1-(1,3-Benzodioxol-5-yl)-3-(5-fluoro-2-methylphenyl)urea chemical structure, C15H13FN2O3, CAS 894265-66-8
1-(1,3-Benzodioxol-5-yl)-3-(5-fluoro-2-methylphenyl)urea
CAS 894265-66-8C15H13FN2O3
1-(1,3-Benzodioxol-5-yl)-3-(2-fluoro-5-methylphenyl)urea chemical structure, C15H13FN2O3, CAS 894265-73-7
1-(1,3-Benzodioxol-5-yl)-3-(2-fluoro-5-methylphenyl)urea
CAS 894265-73-7C15H13FN2O3
1-(1,3-Benzodioxol-5-yl)-3-(3-ethylphenyl)urea chemical structure, C16H16N2O3, CAS 893344-81-5
1-(1,3-Benzodioxol-5-yl)-3-(3-ethylphenyl)urea
CAS 893344-81-5C16H16N2O3
1-(1,3-Benzodioxol-5-yl)-3-(3-fluoro-4-methylphenyl)urea chemical structure, C15H13FN2O3, CAS 894266-50-3
1-(1,3-Benzodioxol-5-yl)-3-(3-fluoro-4-methylphenyl)urea
CAS 894266-50-3C15H13FN2O3
1-(1,3-Benzodioxol-5-yl)-3-(3,4-difluorophenyl)urea chemical structure, C14H10F2N2O3, CAS 218135-58-1
1-(1,3-Benzodioxol-5-yl)-3-(3,4-difluorophenyl)urea
CAS 218135-58-1C14H10F2N2O3
1-(1,3-Benzodioxol-5-yl)-3-(5-chloro-2-methoxyphenyl)urea chemical structure, C15H13ClN2O4, CAS 890586-92-2
1-(1,3-Benzodioxol-5-yl)-3-(5-chloro-2-methoxyphenyl)urea
CAS 890586-92-2C15H13ClN2O4