Murcko scaffold
Ring system with 3 rings and 25 atoms
14 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 25
- Chemicals
- 14
- With full pages
- 1
Scaffold SMILES
O=C(COc1ccccc1C=C1SC(=O)NC1=O)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 14 of 14 chemicals
![Methyl [(5E)-5-(2-{2-[(4-methylphenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate chemical structure, C22H20N2O6S, CAS 593272-32-3](/s/BKZPZGOIFMTVNM-WOJGMQOQSA-N.svg)
Methyl [(5E)-5-(2-{2-[(4-methylphenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
CAS 593272-32-3C22H20N2O6S
![2-[2-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-fluorophenyl)acetamide chemical structure, C18H13FN2O4S, CAS 867041-13-2](/s/OREVLWPOWURGMU-DHDCSXOGSA-N.svg)
2-[2-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-fluorophenyl)acetamide
CAS 867041-13-2C18H13FN2O4S
![2-[2-[(E)-(2,4-Dioxo-3-prop-2-ynyl-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-methylphenyl)acetamide chemical structure, C22H18N2O4S, CAS 432497-04-6](/s/ZTQKOALRFIRVQG-CPNJWEJPSA-N.svg)
2-[2-[(E)-(2,4-Dioxo-3-prop-2-ynyl-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-methylphenyl)acetamide
CAS 432497-04-6C22H18N2O4S
![Methyl [(5E)-2,4-dioxo-5-{2-[2-oxo-2-(phenylamino)ethoxy]benzylidene}-1,3-thiazolidin-3-yl]acetate chemical structure, C21H18N2O6S, CAS 500135-24-0](/s/BQNFQRVHKWBOMD-GZTJUZNOSA-N.svg)
Methyl [(5E)-2,4-dioxo-5-{2-[2-oxo-2-(phenylamino)ethoxy]benzylidene}-1,3-thiazolidin-3-yl]acetate
CAS 500135-24-0C21H18N2O6S
![2-[2-[(E)-(3-Ethyl-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-6-methoxyphenoxy]-N-(4-fluorophenyl)acetamide chemical structure, C21H19FN2O5S, CAS 692272-91-6](/s/QDCAPMMHZTZHKN-GZTJUZNOSA-N.svg)
2-[2-[(E)-(3-Ethyl-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-6-methoxyphenoxy]-N-(4-fluorophenyl)acetamide
CAS 692272-91-6C21H19FN2O5S
![2-[2-[(E)-(2,4-Dioxo-3-prop-2-enyl-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-phenylacetamide chemical structure, C21H18N2O4S, CAS 593265-96-4](/s/KPGPBEOUXMDYHW-QGOAFFKASA-N.svg)
2-[2-[(E)-(2,4-Dioxo-3-prop-2-enyl-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-phenylacetamide
CAS 593265-96-4C21H18N2O4S
![2-[2-[(E)-(2,4-Dioxo-3-prop-2-ynyl-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-fluorophenyl)acetamide chemical structure, C21H15FN2O4S, CAS 431995-43-6](/s/WLFMXBMXNXJPIZ-LDADJPATSA-N.svg)
2-[2-[(E)-(2,4-Dioxo-3-prop-2-ynyl-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-fluorophenyl)acetamide
CAS 431995-43-6C21H15FN2O4S
![Ethyl [(5E)-5-(2-{2-[(4-fluorophenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate chemical structure, C22H19FN2O6S, CAS 431993-92-9](/s/OQXZHTXBOHYSPL-WOJGMQOQSA-N.svg)
Ethyl [(5E)-5-(2-{2-[(4-fluorophenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
CAS 431993-92-9C22H19FN2O6S
![Ethyl 2-[(5E)-5-(3-methoxy-2-{2-[(4-methylphenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate chemical structure, C25H26N2O7S, CAS 1084610-04-7](/s/CDNQRAPZXUDJBQ-DEDYPNTBSA-N.svg)
Ethyl 2-[(5E)-5-(3-methoxy-2-{2-[(4-methylphenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
CAS 1084610-04-7C25H26N2O7S
![Methyl 2-[(5E)-2,4-dioxo-5-{2-[2-oxo-2-(phenylamino)ethoxy]benzylidene}-1,3-thiazolidin-3-yl]propanoate chemical structure, C22H20N2O6S, CAS 692268-54-5](/s/SKMNSDGKUODECX-LDADJPATSA-N.svg)
Methyl 2-[(5E)-2,4-dioxo-5-{2-[2-oxo-2-(phenylamino)ethoxy]benzylidene}-1,3-thiazolidin-3-yl]propanoate
CAS 692268-54-5C22H20N2O6S
![Methyl 2-[(5E)-5-(2-{2-[(4-methylphenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate chemical structure, C23H22N2O6S, CAS 692270-57-8](/s/JDUCRIXHLAQKAO-XDHOZWIPSA-N.svg)
Methyl 2-[(5E)-5-(2-{2-[(4-methylphenyl)amino]-2-oxoethoxy}benzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
CAS 692270-57-8C23H22N2O6S
![Methyl 2-[(5E)-5-(2-{2-[(4-fluorophenyl)amino]-2-oxoethoxy}-3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate chemical structure, C23H21FN2O7S, CAS 1084609-77-7](/s/PVDBNDAPLUTIBI-WOJGMQOQSA-N.svg)
Methyl 2-[(5E)-5-(2-{2-[(4-fluorophenyl)amino]-2-oxoethoxy}-3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
CAS 1084609-77-7C23H21FN2O7S
![2-[4-Chloro-2-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-fluorophenyl)acetamide chemical structure, C18H12ClFN2O4S, CAS 868237-72-3](/s/MGPCOEYLRPVNEW-NVNXTCNLSA-N.svg)
2-[4-Chloro-2-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-(4-fluorophenyl)acetamide
CAS 868237-72-3C18H12ClFN2O4S
![2-[4-Chloro-2-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-phenylacetamide chemical structure, C18H13ClN2O4S, CAS 880796-86-1](/s/ZVMAACYNAYELJS-DHDCSXOGSA-N.svg)
2-[4-Chloro-2-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-N-phenylacetamide
CAS 880796-86-1C18H13ClN2O4S
Related scaffolds
Same ring framework with different atoms or bond orders
