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Murcko scaffold

Ring system with 4 rings and 24 atoms

18 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
18
With full pages
2
Scaffold SMILES

O=C(c1ccccc1)N1CCc2ccccc2C1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCc2ccccc2C1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-(4-Fluorobenzoyl)-6,7-dimethoxy-1-(3-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C24H21FN2O5, CAS 380651-41-2
2-(4-Fluorobenzoyl)-6,7-dimethoxy-1-(3-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline
CAS 380651-41-2C24H21FN2O5
[6,7-Dimethoxy-1-(3-nitrophenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-phenylmethanone chemical structure, C24H22N2O5, CAS 380651-40-1
[6,7-Dimethoxy-1-(3-nitrophenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-phenylmethanone
CAS 380651-40-1C24H22N2O5
2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C24H23NO3, CAS 66040-36-6
2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 66040-36-6C24H23NO3
(6,7-Dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(3,4-dimethoxyphenyl)methanone chemical structure, C26H27NO5, CAS 514793-11-4
(6,7-Dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(3,4-dimethoxyphenyl)methanone
CAS 514793-11-4C26H27NO5
6,7-Dimethoxy-2-(3-methoxybenzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C25H25NO4, CAS 497089-29-9
6,7-Dimethoxy-2-(3-methoxybenzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 497089-29-9C25H25NO4
6,7-Dimethoxy-2-(4-methoxybenzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C25H25NO4, CAS 514793-05-6
6,7-Dimethoxy-2-(4-methoxybenzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 514793-05-6C25H25NO4
Isoquinoline, 2-(3-bromobenzoyl)-1-(2-chlorophenyl)-1,2,3,4-tetrahydro- chemical structure, C22H17BrClNO, CAS 828286-19-7
Isoquinoline, 2-(3-bromobenzoyl)-1-(2-chlorophenyl)-1,2,3,4-tetrahydro-
CAS 828286-19-7C22H17BrClNO
(4-Chlorophenyl)[1-(2-chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl]methanone chemical structure, C22H17Cl2NO, CAS 828286-17-5
(4-Chlorophenyl)[1-(2-chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl]methanone
CAS 828286-17-5C22H17Cl2NO
(3-Chlorophenyl)[1-(2-chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl]methanone chemical structure, C22H17Cl2NO, CAS 828286-15-3
(3-Chlorophenyl)[1-(2-chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl]methanone
CAS 828286-15-3C22H17Cl2NO
(2-Chlorophenyl)[1-(2-chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl]methanone chemical structure, C22H17Cl2NO, CAS 828286-13-1
(2-Chlorophenyl)[1-(2-chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl]methanone
CAS 828286-13-1C22H17Cl2NO
[1-(2-Chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl](3-nitrophenyl)methanone chemical structure, C22H17ClN2O3, CAS 828286-11-9
[1-(2-Chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl](3-nitrophenyl)methanone
CAS 828286-11-9C22H17ClN2O3
[1-(2-Chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl](2-nitrophenyl)methanone chemical structure, C22H17ClN2O3, CAS 828286-09-5
[1-(2-Chlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl](2-nitrophenyl)methanone
CAS 828286-09-5C22H17ClN2O3
4-(1-(4-Bromophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide chemical structure, C24H23BrN2O5S, CAS 2097875-40-4
4-(1-(4-Bromophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide
CAS 2097875-40-4C24H23BrN2O5S
4-(6-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide chemical structure, C23H22N2O4S, CAS 2097875-73-3
4-(6-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide
CAS 2097875-73-3C23H22N2O4S
4-(6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide chemical structure, C24H24N2O5S, CAS 2097874-86-5
4-(6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide
CAS 2097874-86-5C24H24N2O5S
4-(1-(4-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide chemical structure, C24H23FN2O5S, CAS 2097875-30-2
4-(1-(4-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide
CAS 2097875-30-2C24H23FN2O5S
4-(1-Phenyl-6-propoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide chemical structure, C25H26N2O4S, CAS 2097879-17-7
4-(1-Phenyl-6-propoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide
CAS 2097879-17-7C25H26N2O4S
4-(1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide chemical structure, C24H23ClN2O5S, CAS 2097877-73-9
4-(1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzenesulfonamide
CAS 2097877-73-9C24H23ClN2O5S