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Murcko scaffold

Ring system with 4 rings and 25 atoms

60 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
60
With full pages
1
Scaffold SMILES

O=S(=O)(c1ccccc1)c1cnc2ccccc2c1N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1ccccc1)c1cnc2ccccc2c1N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 60 chemicals

3-(Benzenesulfonyl)-6-ethyl-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C22H25N3O2S, CAS 866812-01-3
3-(Benzenesulfonyl)-6-ethyl-4-(4-methylpiperazin-1-yl)quinoline
CAS 866812-01-3C22H25N3O2S
3-(Benzenesulfonyl)-6-chloro-4-(4-ethylpiperazin-1-yl)quinoline chemical structure, C21H22ClN3O2S, CAS 866812-05-7
3-(Benzenesulfonyl)-6-chloro-4-(4-ethylpiperazin-1-yl)quinoline
CAS 866812-05-7C21H22ClN3O2S
3-(Benzenesulfonyl)-6-methyl-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C21H23N3O2S, CAS 872200-25-4
3-(Benzenesulfonyl)-6-methyl-4-(4-methylpiperazin-1-yl)quinoline
CAS 872200-25-4C21H23N3O2S
3-(Benzenesulfonyl)-6-methoxy-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C21H23N3O3S, CAS 866843-16-5
3-(Benzenesulfonyl)-6-methoxy-4-(4-methylpiperazin-1-yl)quinoline
CAS 866843-16-5C21H23N3O3S
3-(Benzenesulfonyl)-6-ethoxy-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C22H25N3O3S, CAS 866843-17-6
3-(Benzenesulfonyl)-6-ethoxy-4-(4-methylpiperazin-1-yl)quinoline
CAS 866843-17-6C22H25N3O3S
3-(Benzenesulfonyl)-4-(4-ethylpiperazin-1-yl)quinoline chemical structure, C21H23N3O2S, CAS 866843-18-7
3-(Benzenesulfonyl)-4-(4-ethylpiperazin-1-yl)quinoline
CAS 866843-18-7C21H23N3O2S
3-(Benzenesulfonyl)-6-ethyl-4-(4-ethylpiperazin-1-yl)quinoline chemical structure, C23H27N3O2S, CAS 866843-19-8
3-(Benzenesulfonyl)-6-ethyl-4-(4-ethylpiperazin-1-yl)quinoline
CAS 866843-19-8C23H27N3O2S
3-(Benzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C20H21N3O2S, CAS 866844-25-9
3-(Benzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline
CAS 866844-25-9C20H21N3O2S
3-(Benzenesulfonyl)-6-fluoro-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C20H20FN3O2S, CAS 866844-26-0
3-(Benzenesulfonyl)-6-fluoro-4-(4-methylpiperazin-1-yl)quinoline
CAS 866844-26-0C20H20FN3O2S
3-(Benzenesulfonyl)-4-(4-ethylpiperazin-1-yl)-6-methylquinoline chemical structure, C22H25N3O2S, CAS 866844-27-1
3-(Benzenesulfonyl)-4-(4-ethylpiperazin-1-yl)-6-methylquinoline
CAS 866844-27-1C22H25N3O2S
3-(4-Methylbenzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C21H23N3O2S, CAS 866847-37-2
3-(4-Methylbenzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline
CAS 866847-37-2C21H23N3O2S
4-(4-Ethylpiperazin-1-yl)-6-methyl-3-(4-methylbenzenesulfonyl)quinoline chemical structure, C23H27N3O2S, CAS 866847-38-3
4-(4-Ethylpiperazin-1-yl)-6-methyl-3-(4-methylbenzenesulfonyl)quinoline
CAS 866847-38-3C23H27N3O2S
6-Ethyl-4-(4-ethylpiperazin-1-yl)-3-tosylquinoline chemical structure, C24H29N3O2S, CAS 866847-39-4
6-Ethyl-4-(4-ethylpiperazin-1-yl)-3-tosylquinoline
CAS 866847-39-4C24H29N3O2S
6-Methoxy-3-(4-methylbenzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C22H25N3O3S, CAS 866848-42-2
6-Methoxy-3-(4-methylbenzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline
CAS 866848-42-2C22H25N3O3S
6,7-Dimethoxy-3-(4-methylphenyl)sulfonyl-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C23H27N3O4S, CAS 866848-44-4
6,7-Dimethoxy-3-(4-methylphenyl)sulfonyl-4-(4-methylpiperazin-1-yl)quinoline
CAS 866848-44-4C23H27N3O4S
3-(4-Chlorophenyl)sulfonyl-6-fluoro-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C20H19ClFN3O2S, CAS 866871-49-0
3-(4-Chlorophenyl)sulfonyl-6-fluoro-4-(4-methylpiperazin-1-yl)quinoline
CAS 866871-49-0C20H19ClFN3O2S
4-(4-Ethylpiperazin-1-yl)-3-(4-methylbenzenesulfonyl)quinoline chemical structure, C22H25N3O2S, CAS 866871-50-3
4-(4-Ethylpiperazin-1-yl)-3-(4-methylbenzenesulfonyl)quinoline
CAS 866871-50-3C22H25N3O2S
3-(4-Chlorophenyl)sulfonyl-4-(4-ethylpiperazin-1-yl)-6-fluoroquinoline chemical structure, C21H21ClFN3O2S, CAS 866871-51-4
3-(4-Chlorophenyl)sulfonyl-4-(4-ethylpiperazin-1-yl)-6-fluoroquinoline
CAS 866871-51-4C21H21ClFN3O2S
6-Ethyl-3-(4-methylphenyl)sulfonyl-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C23H27N3O2S, CAS 866895-33-2
6-Ethyl-3-(4-methylphenyl)sulfonyl-4-(4-methylpiperazin-1-yl)quinoline
CAS 866895-33-2C23H27N3O2S
3-(4-Chlorobenzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C20H20ClN3O2S, CAS 866895-34-3
3-(4-Chlorobenzenesulfonyl)-4-(4-methylpiperazin-1-yl)quinoline
CAS 866895-34-3C20H20ClN3O2S
3-(4-Chlorophenyl)sulfonyl-6-methoxy-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C21H22ClN3O3S, CAS 866895-35-4
3-(4-Chlorophenyl)sulfonyl-6-methoxy-4-(4-methylpiperazin-1-yl)quinoline
CAS 866895-35-4C21H22ClN3O3S
3-(3,4-Dimethylbenzenesulfonyl)-4-(4-ethylpiperazin-1-yl)quinoline chemical structure, C23H27N3O2S, CAS 872208-46-3
3-(3,4-Dimethylbenzenesulfonyl)-4-(4-ethylpiperazin-1-yl)quinoline
CAS 872208-46-3C23H27N3O2S
3-(Benzenesulfonyl)-6-ethoxy-4-(4-ethylpiperazin-1-yl)quinoline chemical structure, C23H27N3O3S, CAS 866843-21-2
3-(Benzenesulfonyl)-6-ethoxy-4-(4-ethylpiperazin-1-yl)quinoline
CAS 866843-21-2C23H27N3O3S
6-Ethoxy-3-(4-methylphenyl)sulfonyl-4-(4-methylpiperazin-1-yl)quinoline chemical structure, C23H27N3O3S, CAS 866848-43-3
6-Ethoxy-3-(4-methylphenyl)sulfonyl-4-(4-methylpiperazin-1-yl)quinoline
CAS 866848-43-3C23H27N3O3S