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Murcko scaffold

Ring system with 4 rings and 25 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
12
With full pages
3
Scaffold SMILES

O=C1CCCC2=C1C(c1ccccc1)C(C(=O)N1CCOCC1)=CN2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCCC2=C1C(c1ccccc1)C(C(=O)N1CCOCC1)=CN2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

2-Methyl-3-(morpholine-4-carbonyl)-4-(4-nitrophenyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one chemical structure, C21H23N3O5, CAS 423137-16-0
2-Methyl-3-(morpholine-4-carbonyl)-4-(4-nitrophenyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one
CAS 423137-16-0C21H23N3O5
4-(3-Bromo-4-fluorophenyl)-2-methyl-3-(morpholine-4-carbonyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one chemical structure, C21H22BrFN2O3, CAS 423139-58-6
4-(3-Bromo-4-fluorophenyl)-2-methyl-3-(morpholine-4-carbonyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one
CAS 423139-58-6C21H22BrFN2O3
4-(2-Chloro-6-fluorophenyl)-2-methyl-3-(4-morpholinylcarbonyl)-4,6,7,8-tetrahydro-5(1H)-quinolinone chemical structure, C21H22ClFN2O3, CAS 423137-40-0
4-(2-Chloro-6-fluorophenyl)-2-methyl-3-(4-morpholinylcarbonyl)-4,6,7,8-tetrahydro-5(1H)-quinolinone
CAS 423137-40-0C21H22ClFN2O3
4-(3-Bromo-4-methoxyphenyl)-2-methyl-3-(4-morpholinylcarbonyl)-4,6,7,8-tetrahydro-5(1H)-quinolinone chemical structure, C22H25BrN2O4, CAS 423137-79-5
4-(3-Bromo-4-methoxyphenyl)-2-methyl-3-(4-morpholinylcarbonyl)-4,6,7,8-tetrahydro-5(1H)-quinolinone
CAS 423137-79-5C22H25BrN2O4
2,7,7-Trimethyl-3-(morpholine-4-carbonyl)-4-(2,4,5-trimethoxyphenyl)-1,4,6,8-tetrahydroquinolin-5-one chemical structure, C26H34N2O6, CAS 423138-00-5
2,7,7-Trimethyl-3-(morpholine-4-carbonyl)-4-(2,4,5-trimethoxyphenyl)-1,4,6,8-tetrahydroquinolin-5-one
CAS 423138-00-5C26H34N2O6
2,7,7-Trimethyl-3-(morpholine-4-carbonyl)-4-(4-nitrophenyl)-1,4,6,8-tetrahydroquinolin-5-one chemical structure, C23H27N3O5, CAS 423140-06-1
2,7,7-Trimethyl-3-(morpholine-4-carbonyl)-4-(4-nitrophenyl)-1,4,6,8-tetrahydroquinolin-5-one
CAS 423140-06-1C23H27N3O5
4-(3-Hydroxy-4-methoxyphenyl)-2,7,7-trimethyl-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one chemical structure, C24H30N2O5, CAS 423137-76-2
4-(3-Hydroxy-4-methoxyphenyl)-2,7,7-trimethyl-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one
CAS 423137-76-2C24H30N2O5
4-(3-Chloro-4-hydroxy-5-methoxyphenyl)-2,7,7-trimethyl-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one chemical structure, C24H29ClN2O5, CAS 423139-70-2
4-(3-Chloro-4-hydroxy-5-methoxyphenyl)-2,7,7-trimethyl-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one
CAS 423139-70-2C24H29ClN2O5
4-(4-Chlorophenyl)-2,7,7-trimethyl-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one chemical structure, C23H27ClN2O3, CAS 423138-75-4
4-(4-Chlorophenyl)-2,7,7-trimethyl-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one
CAS 423138-75-4C23H27ClN2O3
2-Methyl-3-(morpholine-4-carbonyl)-4-[4-(trifluoromethyl)phenyl]-4,6,7,8-tetrahydro-1H-quinolin-5-one chemical structure, C22H23F3N2O3, CAS 423137-46-6
2-Methyl-3-(morpholine-4-carbonyl)-4-[4-(trifluoromethyl)phenyl]-4,6,7,8-tetrahydro-1H-quinolin-5-one
CAS 423137-46-6C22H23F3N2O3
2,7,7-Trimethyl-4-(4-methylsulfanylphenyl)-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one chemical structure, C24H30N2O3S, CAS 423139-85-9
2,7,7-Trimethyl-4-(4-methylsulfanylphenyl)-3-(morpholine-4-carbonyl)-1,4,6,8-tetrahydroquinolin-5-one
CAS 423139-85-9C24H30N2O3S
2-Methyl-3-(morpholin-4-ylcarbonyl)-4-[4-(trifluoromethoxy)phenyl]-4,6,7,8-tetrahydroquinolin-5(1H)-one chemical structure, C22H23F3N2O4, CAS 423139-29-1
2-Methyl-3-(morpholin-4-ylcarbonyl)-4-[4-(trifluoromethoxy)phenyl]-4,6,7,8-tetrahydroquinolin-5(1H)-one
CAS 423139-29-1C22H23F3N2O4