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Murcko scaffold

Ring system with 3 rings and 18 atoms

63 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
63
With full pages
20
Scaffold SMILES

O=C1CC(c2ccccc2)C2=C(CCCC2=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)C2=C(CCCC2=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 63 chemicals

7,7-Dimethyl-4-(3-nitrophenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C17H18N2O4, CAS 128839-31-6
7,7-Dimethyl-4-(3-nitrophenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 128839-31-6C17H18N2O4
1,7,7-Trimethyl-4-(3-nitrophenyl)-3,4,6,8-tetrahydroquinoline-2,5-dione chemical structure, C18H20N2O4, CAS 131447-62-6
1,7,7-Trimethyl-4-(3-nitrophenyl)-3,4,6,8-tetrahydroquinoline-2,5-dione
CAS 131447-62-6C18H20N2O4
4-(4-Chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C17H18ClNO2, CAS 128839-42-9
4-(4-Chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 128839-42-9C17H18ClNO2
1,7,7-Trimethyl-4-(4-nitrophenyl)-3,4,6,8-tetrahydroquinoline-2,5-dione chemical structure, C18H20N2O4, CAS 131447-61-5
1,7,7-Trimethyl-4-(4-nitrophenyl)-3,4,6,8-tetrahydroquinoline-2,5-dione
CAS 131447-61-5C18H20N2O4
7,7-Dimethyl-4-(4-nitrophenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C17H18N2O4, CAS 128839-30-5
7,7-Dimethyl-4-(4-nitrophenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 128839-30-5C17H18N2O4
1,7,7-Trimethyl-4-(2-nitrophenyl)-3,4,6,8-tetrahydroquinoline-2,5-dione chemical structure, C18H20N2O4, CAS 131447-63-7
1,7,7-Trimethyl-4-(2-nitrophenyl)-3,4,6,8-tetrahydroquinoline-2,5-dione
CAS 131447-63-7C18H20N2O4
3-[N-(2-Cyanoethyl)-4-(7,7-dimethyl-2,5-dioxo-3,4,6,8-tetrahydro-1H-quinolin-4-yl)anilino]propanenitrile chemical structure, C23H26N4O2, CAS 128839-40-7
3-[N-(2-Cyanoethyl)-4-(7,7-dimethyl-2,5-dioxo-3,4,6,8-tetrahydro-1H-quinolin-4-yl)anilino]propanenitrile
CAS 128839-40-7C23H26N4O2
4-(4-Nitrophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C15H14N2O4, CAS 418798-96-6
4-(4-Nitrophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 418798-96-6C15H14N2O4
7,7-Dimethyl-4-phenyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C17H19NO2, CAS 128839-29-2
7,7-Dimethyl-4-phenyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 128839-29-2C17H19NO2
7,7-Dimethyl-4-(2-nitrophenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C17H18N2O4, CAS 128839-32-7
7,7-Dimethyl-4-(2-nitrophenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 128839-32-7C17H18N2O4
4-(2,4-Dimethoxyphenyl)-1,7,7-trimethyl-3,4,6,8-tetrahydroquinoline-2,5-dione chemical structure, C20H25NO4, CAS 131447-67-1
4-(2,4-Dimethoxyphenyl)-1,7,7-trimethyl-3,4,6,8-tetrahydroquinoline-2,5-dione
CAS 131447-67-1C20H25NO4
1,7,7-Trimethyl-4-phenyl-3,4,6,8-tetrahydroquinoline-2,5-dione chemical structure, C18H21NO2, CAS 131447-60-4
1,7,7-Trimethyl-4-phenyl-3,4,6,8-tetrahydroquinoline-2,5-dione
CAS 131447-60-4C18H21NO2
4-(2,4-Dichlorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C15H13Cl2NO2, CAS 696639-73-3
4-(2,4-Dichlorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 696639-73-3C15H13Cl2NO2
7,7-Dimethyl-4-[2-(trifluoromethyl)phenyl]-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C18H18F3NO2, CAS 847466-91-5
7,7-Dimethyl-4-[2-(trifluoromethyl)phenyl]-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 847466-91-5C18H18F3NO2
4-(2,4-Dimethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C17H19NO4, CAS 847467-07-6
4-(2,4-Dimethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 847467-07-6C17H19NO4
4-(2,3-Dimethoxyphenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C19H23NO4, CAS 847466-75-5
4-(2,3-Dimethoxyphenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 847466-75-5C19H23NO4
4-(3,4-Dichlorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C15H13Cl2NO2, CAS 727666-95-7
4-(3,4-Dichlorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 727666-95-7C15H13Cl2NO2
4-(4-Bromophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C15H14BrNO2, CAS 847466-85-7
4-(4-Bromophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 847466-85-7C15H14BrNO2
4-(2-Bromophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C15H14BrNO2, CAS 847466-82-4
4-(2-Bromophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 847466-82-4C15H14BrNO2
4-(2-Chloro-6-fluorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C17H17ClFNO2, CAS 847509-62-0
4-(2-Chloro-6-fluorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 847509-62-0C17H17ClFNO2
7,7-Dimethyl-4-(2-methylphenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C18H21NO2, CAS 847466-74-4
7,7-Dimethyl-4-(2-methylphenyl)-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 847466-74-4C18H21NO2
4-(2-Bromophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione chemical structure, C17H18BrNO2, CAS 847466-63-1
4-(2-Bromophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
CAS 847466-63-1C17H18BrNO2
4-(2-Ethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C17H19NO3, CAS 727667-01-8
4-(2-Ethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 727667-01-8C17H19NO3
4-(3-Ethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C17H19NO3, CAS 847466-83-5
4-(3-Ethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 847466-83-5C17H19NO3