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Murcko scaffold

Ring system with 5 rings and 23 atoms

19 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 23
Chemicals: 19
With full pages: 7

Scaffold SMILES

O=C1OCC2=C1C(c1ccccc1)c1cc3c(cc1N2)OCO3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1OCC2=C1C(c1ccccc1)c1cc3c(cc1N2)OCO3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

9-(2-Bromophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C18H12BrNO4, CAS 866138-52-5

9-(2-Bromophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 866138-52-5C₁₈H₁₂BrNO₄

9-(4-Isopropylphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C21H19NO4, CAS 866138-53-6

9-(4-Isopropylphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 866138-53-6C₂₁H₁₉NO₄

9-(2-Ethoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C20H17NO5, CAS 866138-51-4

9-(2-Ethoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 866138-51-4C₂₀H₁₇NO₅

9-(2,5-Dimethoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C20H17NO6, CAS 866050-83-1

9-(2,5-Dimethoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 866050-83-1C₂₀H₁₇NO₆

9-[4-(tert-Butyl)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C22H21NO4, CAS 866138-50-3

9-[4-(tert-Butyl)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 866138-50-3C₂₂H₂₁NO₄

9-(4-Fluorophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C18H12FNO4, CAS 861208-09-5

9-(4-Fluorophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 861208-09-5C₁₈H₁₂FNO₄

9-(2-Methoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C19H15NO5, CAS 866050-82-0

9-(2-Methoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 866050-82-0C₁₉H₁₅NO₅

N-[4-(8-Oxo-5,6,8,9-tetrahydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-9-yl)phenyl]acetamide chemical structure, C20H16N2O5, CAS 866050-84-2

N-[4-(8-Oxo-5,6,8,9-tetrahydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-9-yl)phenyl]acetamide

CAS 866050-84-2C₂₀H₁₆N₂O₅

$8-(4-Nitrophenyl)-5,12,14-trioxa-2-azatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),3(7),10,15-tetraen-6-one chemical structure, C18H12N2O6, CAS 7243-16-5$

8-(4-Nitrophenyl)-5,12,14-trioxa-2-azatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),3(7),10,15-tetraen-6-one

CAS 7243-16-5C₁₈H₁₂N₂O₆

9-[3-Methoxy-4-(2-propynyloxy)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C22H17NO6, CAS 866142-43-0

9-[3-Methoxy-4-(2-propynyloxy)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 866142-43-0C₂₂H₁₇NO₆

9-[4-Methoxy-3-(2-propynyloxy)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C22H17NO6, CAS 900018-70-4

9-[4-Methoxy-3-(2-propynyloxy)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 900018-70-4C₂₂H₁₇NO₆

2-(8-Oxo-5,6,8,9-tetrahydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-9-yl)benzenecarboxylic acid chemical structure, C19H13NO6, CAS 882747-22-0

2-(8-Oxo-5,6,8,9-tetrahydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-9-yl)benzenecarboxylic acid

CAS 882747-22-0C₁₉H₁₃NO₆

9-[2-Fluoro-5-(trifluoromethyl)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C19H11F4NO4, CAS 882747-23-1

9-[2-Fluoro-5-(trifluoromethyl)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 882747-23-1C₁₉H₁₁F₄NO₄

9-(2,4-Dichlorophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C18H11Cl2NO4, CAS 882747-24-2

9-(2,4-Dichlorophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 882747-24-2C₁₈H₁₁Cl₂NO₄

9-(2-Nitrophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C18H12N2O6, CAS 900014-88-2

9-(2-Nitrophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 900014-88-2C₁₈H₁₂N₂O₆

9-[2-(Trifluoromethyl)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C19H12F3NO4, CAS 900014-89-3

9-[2-(Trifluoromethyl)phenyl]-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 900014-89-3C₁₉H₁₂F₃NO₄

9-(3-Bromophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C18H12BrNO4, CAS 867068-21-1

9-(3-Bromophenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 867068-21-1C₁₈H₁₂BrNO₄

6,9-Dihydro-9-(3-methylphenyl)-1,3-dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C19H15NO4, CAS 867068-23-3

6,9-Dihydro-9-(3-methylphenyl)-1,3-dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 867068-23-3C₁₉H₁₅NO₄

9-(3-Fluorophenyl)-5-(2-hydroxyethyl)-6,9-dihydro-[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one chemical structure, C20H16FNO5, CAS 2376580-08-2

9-(3-Fluorophenyl)-5-(2-hydroxyethyl)-6,9-dihydro-[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

CAS 2376580-08-2C₂₀H₁₆FNO₅