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Murcko scaffold

Ring system with 4 rings and 26 atoms

124 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
124
With full pages
3
Scaffold SMILES

c1ccc(COc2ccc(-c3ncncc3-c3ccccc3)cc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(COc2ccc(-c3ncncc3-c3ccccc3)cc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 124 chemicals

5-[(2,4-Dichlorobenzyl)oxy]-2-[5-phenyl-6-(trifluoromethyl)-4-pyrimidinyl]phenol chemical structure, C24H15Cl2F3N2O2, CAS 849914-30-3
5-[(2,4-Dichlorobenzyl)oxy]-2-[5-phenyl-6-(trifluoromethyl)-4-pyrimidinyl]phenol
CAS 849914-30-3C24H15Cl2F3N2O2
2-[2-Amino-5-(2-methoxyphenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(4-bromobenzyl)oxy]phenol chemical structure, C25H19BrF3N3O3, CAS 896809-45-3
2-[2-Amino-5-(2-methoxyphenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(4-bromobenzyl)oxy]phenol
CAS 896809-45-3C25H19BrF3N3O3
2-[2-Amino-5-(4-methoxyphenyl)pyrimidin-4-yl]-5-[(4-chlorobenzyl)oxy]phenol chemical structure, C24H20ClN3O3, CAS 896807-52-6
2-[2-Amino-5-(4-methoxyphenyl)pyrimidin-4-yl]-5-[(4-chlorobenzyl)oxy]phenol
CAS 896807-52-6C24H20ClN3O3
2-(2-Amino-6-methyl-5-phenyl-4-pyrimidinyl)-5-[(2-chloro-6-fluorobenzyl)oxy]phenol chemical structure, C24H19ClFN3O2, CAS 896815-72-8
2-(2-Amino-6-methyl-5-phenyl-4-pyrimidinyl)-5-[(2-chloro-6-fluorobenzyl)oxy]phenol
CAS 896815-72-8C24H19ClFN3O2
2-[2-Amino-5-(4-bromophenyl)-4-pyrimidinyl]-5-[(2-chloro-4-fluorobenzyl)oxy]phenol chemical structure, C23H16BrClFN3O2, CAS 896818-22-7
2-[2-Amino-5-(4-bromophenyl)-4-pyrimidinyl]-5-[(2-chloro-4-fluorobenzyl)oxy]phenol
CAS 896818-22-7C23H16BrClFN3O2
2-[2-Amino-5-(2-methoxyphenyl)-4-pyrimidinyl]-5-[(2,4-dichlorobenzyl)oxy]phenol chemical structure, C24H19Cl2N3O3, CAS 896817-27-9
2-[2-Amino-5-(2-methoxyphenyl)-4-pyrimidinyl]-5-[(2,4-dichlorobenzyl)oxy]phenol
CAS 896817-27-9C24H19Cl2N3O3
2-[2-Amino-5-(4-methoxyphenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2,4-dichlorobenzyl)oxy]phenol chemical structure, C25H18Cl2F3N3O3, CAS 896823-84-0
2-[2-Amino-5-(4-methoxyphenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2,4-dichlorobenzyl)oxy]phenol
CAS 896823-84-0C25H18Cl2F3N3O3
2-[2-Amino-5-phenyl-6-(trifluoromethyl)pyrimidin-4-yl]-5-(benzyloxy)phenol chemical structure, C24H18F3N3O2, CAS 896827-96-6
2-[2-Amino-5-phenyl-6-(trifluoromethyl)pyrimidin-4-yl]-5-(benzyloxy)phenol
CAS 896827-96-6C24H18F3N3O2
2-[2-Amino-5-(2-methoxyphenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2-chloro-6-fluorobenzyl)oxy]phenol chemical structure, C25H18ClF4N3O3, CAS 896831-97-3
2-[2-Amino-5-(2-methoxyphenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2-chloro-6-fluorobenzyl)oxy]phenol
CAS 896831-97-3C25H18ClF4N3O3
2-(2-Amino-6-methyl-5-phenylpyrimidin-4-yl)-5-[(4-bromophenyl)methoxy]phenol chemical structure, C24H20BrN3O2, CAS 896832-57-8
2-(2-Amino-6-methyl-5-phenylpyrimidin-4-yl)-5-[(4-bromophenyl)methoxy]phenol
CAS 896832-57-8C24H20BrN3O2
2-(2-Amino-5-phenylpyrimidin-4-yl)-5-[(2,6-dichlorophenyl)methoxy]phenol chemical structure, C23H17Cl2N3O2, CAS 896831-35-9
2-(2-Amino-5-phenylpyrimidin-4-yl)-5-[(2,6-dichlorophenyl)methoxy]phenol
CAS 896831-35-9C23H17Cl2N3O2
2-(2-Amino-5-phenyl-4-pyrimidinyl)-5-[(4-vinylbenzyl)oxy]phenol chemical structure, C25H21N3O2, CAS 896835-52-2
2-(2-Amino-5-phenyl-4-pyrimidinyl)-5-[(4-vinylbenzyl)oxy]phenol
CAS 896835-52-2C25H21N3O2
2-[2-Amino-5-(4-chlorophenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2,4-dichlorobenzyl)oxy]phenol chemical structure, C24H15Cl3F3N3O2, CAS 896835-32-8
2-[2-Amino-5-(4-chlorophenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2,4-dichlorobenzyl)oxy]phenol
CAS 896835-32-8C24H15Cl3F3N3O2
2-[2-Amino-5-phenyl-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(4-vinylbenzyl)oxy]phenol chemical structure, C26H20F3N3O2, CAS 896839-53-5
2-[2-Amino-5-phenyl-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(4-vinylbenzyl)oxy]phenol
CAS 896839-53-5C26H20F3N3O2
2-[2-Amino-5-(4-chlorophenyl)pyrimidin-4-yl]-5-[(4-bromophenyl)methoxy]phenol chemical structure, C23H17BrClN3O2, CAS 896838-15-6
2-[2-Amino-5-(4-chlorophenyl)pyrimidin-4-yl]-5-[(4-bromophenyl)methoxy]phenol
CAS 896838-15-6C23H17BrClN3O2
2-[2-Amino-5-(4-chlorophenyl)pyrimidin-4-yl]-5-(benzyloxy)phenol chemical structure, C23H18ClN3O2, CAS 896838-99-6
2-[2-Amino-5-(4-chlorophenyl)pyrimidin-4-yl]-5-(benzyloxy)phenol
CAS 896838-99-6C23H18ClN3O2
2-[2-Amino-5-(4-chlorophenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(4-fluorobenzyl)oxy]phenol chemical structure, C24H16ClF4N3O2, CAS 896842-07-2
2-[2-Amino-5-(4-chlorophenyl)-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(4-fluorobenzyl)oxy]phenol
CAS 896842-07-2C24H16ClF4N3O2
2-[2-Amino-5-phenyl-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2-chloro-6-fluorobenzyl)oxy]phenol chemical structure, C24H16ClF4N3O2, CAS 896845-51-5
2-[2-Amino-5-phenyl-6-(trifluoromethyl)-4-pyrimidinyl]-5-[(2-chloro-6-fluorobenzyl)oxy]phenol
CAS 896845-51-5C24H16ClF4N3O2
5-(Benzyloxy)-2-(5-(4-methoxyphenyl)pyrimidin-4-yl)phenol chemical structure, C24H20N2O3, CAS 850160-86-0
5-(Benzyloxy)-2-(5-(4-methoxyphenyl)pyrimidin-4-yl)phenol
CAS 850160-86-0C24H20N2O3
2-[2-Amino-5-(2-methoxyphenyl)-4-pyrimidinyl]-5-[(2-chloro-6-fluorobenzyl)oxy]phenol chemical structure, C24H19ClFN3O3, CAS 896856-74-9
2-[2-Amino-5-(2-methoxyphenyl)-4-pyrimidinyl]-5-[(2-chloro-6-fluorobenzyl)oxy]phenol
CAS 896856-74-9C24H19ClFN3O3
2-[2-Amino-5-(2-methoxyphenyl)-6-methyl-4-pyrimidinyl]-5-[(3-chlorobenzyl)oxy]phenol chemical structure, C25H22ClN3O3, CAS 896856-92-1
2-[2-Amino-5-(2-methoxyphenyl)-6-methyl-4-pyrimidinyl]-5-[(3-chlorobenzyl)oxy]phenol
CAS 896856-92-1C25H22ClN3O3
2-(2-Amino-5-phenyl-4-pyrimidinyl)-5-[(2-chloro-6-fluorobenzyl)oxy]phenol chemical structure, C23H17ClFN3O2, CAS 899394-51-5
2-(2-Amino-5-phenyl-4-pyrimidinyl)-5-[(2-chloro-6-fluorobenzyl)oxy]phenol
CAS 899394-51-5C23H17ClFN3O2
2-[2-Amino-5-(3,4-dimethoxyphenyl)-6-methyl-4-pyrimidinyl]-5-[(4-chlorobenzyl)oxy]phenol chemical structure, C26H24ClN3O4, CAS 899400-81-8
2-[2-Amino-5-(3,4-dimethoxyphenyl)-6-methyl-4-pyrimidinyl]-5-[(4-chlorobenzyl)oxy]phenol
CAS 899400-81-8C26H24ClN3O4
2-(2-Amino-5-(3,4-dimethoxyphenyl)pyrimidin-4-yl)-5-((2-fluorobenzyl)oxy)phenol chemical structure, C25H22FN3O4, CAS 850230-05-6
2-(2-Amino-5-(3,4-dimethoxyphenyl)pyrimidin-4-yl)-5-((2-fluorobenzyl)oxy)phenol
CAS 850230-05-6C25H22FN3O4