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Murcko scaffold

Ring system with 5 rings and 28 atoms

28 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
28
With full pages
1
Scaffold SMILES

O=C(OCC1c2ccccc2-c2ccccc21)N1CCSC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(OCC1c2ccccc2-c2ccccc21)N1CCSC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-phenyl-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H21NO4S, CAS 1822470-91-6
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-phenyl-1,3-thiazolidine-4-carboxylic acid
CAS 1822470-91-6C25H21NO4S
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H21NO5S, CAS 2137446-63-8
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2137446-63-8C25H21NO5S
(4R)-2-[3-(Difluoromethoxy)phenyl]-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H21F2NO5S, CAS 2171351-32-7
(4R)-2-[3-(Difluoromethoxy)phenyl]-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2171351-32-7C26H21F2NO5S
(4R)-3-(9H-Fluoren-9-ylmethoxycarbonyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H20F3NO4S, CAS 2171452-31-4
(4R)-3-(9H-Fluoren-9-ylmethoxycarbonyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazolidine-4-carboxylic acid
CAS 2171452-31-4C26H20F3NO4S
2-(3-Bromophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H20BrNO4S, CAS 2137443-56-0
2-(3-Bromophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2137443-56-0C25H20BrNO4S
2-(2,4-Dimethylphenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C27H25NO4S, CAS 2137459-19-7
2-(2,4-Dimethylphenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2137459-19-7C27H25NO4S
(4S)-2-(2,5-Difluorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H19F2NO4S, CAS 2171411-81-5
(4S)-2-(2,5-Difluorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2171411-81-5C25H19F2NO4S
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-fluorophenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H20FNO4S, CAS 2171675-09-3
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-fluorophenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171675-09-3C25H20FNO4S
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3,4,5-trimethoxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C28H27NO7S, CAS 2171375-77-0
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3,4,5-trimethoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171375-77-0C28H27NO7S
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-methylphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H23NO4S, CAS 2171675-20-8
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-methylphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171675-20-8C26H23NO4S
(4S)-2-(2,4-Dichlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H19Cl2NO4S, CAS 2171428-74-1
(4S)-2-(2,4-Dichlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2171428-74-1C25H19Cl2NO4S
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-[2-(trifluoromethoxy)phenyl]-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H20F3NO5S, CAS 2171453-71-5
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-[2-(trifluoromethoxy)phenyl]-1,3-thiazolidine-4-carboxylic acid
CAS 2171453-71-5C26H20F3NO5S
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H23NO6S, CAS 2171780-03-1
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171780-03-1C26H23NO6S
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-hydroxy-3,5-dimethoxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C27H25NO7S, CAS 2171322-36-2
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-hydroxy-3,5-dimethoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171322-36-2C27H25NO7S
2-(2-Chlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H20ClNO4S, CAS 2171763-80-5
2-(2-Chlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2171763-80-5C25H20ClNO4S
(4S)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(2,3,4-trifluorophenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H18F3NO4S, CAS 2171357-65-4
(4S)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(2,3,4-trifluorophenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171357-65-4C25H18F3NO4S
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3-hydroxy-4-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H23NO6S, CAS 2171440-65-4
(4R)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3-hydroxy-4-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171440-65-4C26H23NO6S
(4S)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H21NO5S, CAS 2171454-48-9
(4S)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171454-48-9C25H21NO5S
(4S)-2-(2,6-Dichlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H19Cl2NO4S, CAS 2171428-78-5
(4S)-2-(2,6-Dichlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2171428-78-5C25H19Cl2NO4S
(4S)-2-(3-Chloro-4-hydroxyphenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H20ClNO5S, CAS 2171375-83-8
(4S)-2-(3-Chloro-4-hydroxyphenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2171375-83-8C25H20ClNO5S
2-(3-Ethoxy-4-hydroxyphenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C27H25NO6S, CAS 2137484-45-6
2-(3-Ethoxy-4-hydroxyphenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2137484-45-6C27H25NO6S
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H23NO5S, CAS 2171555-67-0
3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(4-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2171555-67-0C26H23NO5S
(4S)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid chemical structure, C26H23NO6S, CAS 2137419-56-6
(4S)-3-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
CAS 2137419-56-6C26H23NO6S
(4R)-2-(2,3-Dichlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid chemical structure, C25H19Cl2NO4S, CAS 2580128-36-3
(4R)-2-(2,3-Dichlorophenyl)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,3-thiazolidine-4-carboxylic acid
CAS 2580128-36-3C25H19Cl2NO4S