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Murcko scaffold

Ring system with 5 rings and 28 atoms

49 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
49
With full pages
3
Scaffold SMILES

O=C(OCC1c2ccccc2-c2ccccc21)N1CCCC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(OCC1c2ccccc2-c2ccccc21)N1CCCC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

(2S,5R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-phenylpyrrolidine-2-carboxylic acid chemical structure, C26H23NO4, CAS 215190-21-9
(2S,5R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-phenylpyrrolidine-2-carboxylic acid
CAS 215190-21-9C26H23NO4
Fmoc-(2R,5S)-5-phenyl-pyrrolidine-2-carboxylic acid chemical structure, C26H23NO4, CAS 269078-69-5
Fmoc-(2R,5S)-5-phenyl-pyrrolidine-2-carboxylic acid
CAS 269078-69-5C26H23NO4
3-(1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidin-2-yl)benzoic acid chemical structure, C26H23NO4, CAS 317355-20-7
3-(1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidin-2-yl)benzoic acid
CAS 317355-20-7C26H23NO4
(2S,5S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-phenylpyrrolidine-2-carboxylic acid chemical structure, C26H23NO4, CAS 1219953-60-2
(2S,5S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-phenylpyrrolidine-2-carboxylic acid
CAS 1219953-60-2C26H23NO4
(2R,5R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-phenylpyrrolidine-2-carboxylic acid chemical structure, C26H23NO4, CAS 2171273-43-9
(2R,5R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-phenylpyrrolidine-2-carboxylic acid
CAS 2171273-43-9C26H23NO4
(2S,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid chemical structure, C26H23NO4, CAS 2382034-11-7
(2S,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid
CAS 2382034-11-7C26H23NO4
(2S,3R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid chemical structure, C26H23NO4, CAS 2227775-85-9
(2S,3R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid
CAS 2227775-85-9C26H23NO4
(2R,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid chemical structure, C26H23NO4, CAS 2094028-78-9
(2R,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid
CAS 2094028-78-9C26H23NO4
(2R,3R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid chemical structure, C26H23NO4, CAS 2380362-63-8
(2R,3R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-phenylpyrrolidine-3-carboxylic acid
CAS 2380362-63-8C26H23NO4
rac-(2R,5R)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-5-(4-methoxyphenyl)pyrrolidine-2-carboxylic acid chemical structure, C27H25NO5, CAS 2137034-15-0
rac-(2R,5R)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-5-(4-methoxyphenyl)pyrrolidine-2-carboxylic acid
CAS 2137034-15-0C27H25NO5
rac-(2R,5R)-5-(4-Chlorophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid chemical structure, C26H22ClNO4, CAS 2137034-20-7
rac-(2R,5R)-5-(4-Chlorophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
CAS 2137034-20-7C26H22ClNO4
1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-5-(4-methoxyphenyl)pyrrolidine-2-carboxylic acid chemical structure, C27H25NO5, CAS 2137482-02-9
1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-5-(4-methoxyphenyl)pyrrolidine-2-carboxylic acid
CAS 2137482-02-9C27H25NO5
rac-(2R,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-(3-methoxyphenyl)pyrrolidine-3-carboxylic acid chemical structure, C27H25NO5, CAS 2138388-57-3
rac-(2R,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-(3-methoxyphenyl)pyrrolidine-3-carboxylic acid
CAS 2138388-57-3C27H25NO5
rac-(2R,5R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-(4-fluorophenyl)pyrrolidine-2-carboxylic acid chemical structure, C26H22FNO4, CAS 2138228-46-1
rac-(2R,5R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-(4-fluorophenyl)pyrrolidine-2-carboxylic acid
CAS 2138228-46-1C26H22FNO4
1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3-methoxyphenyl)pyrrolidine-3-carboxylic acid chemical structure, C27H25NO5, CAS 2138133-82-9
1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-(3-methoxyphenyl)pyrrolidine-3-carboxylic acid
CAS 2138133-82-9C27H25NO5
1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-phenylpyrrolidine-3-carboxylic acid chemical structure, C26H23NO4, CAS 1823413-04-2
1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-phenylpyrrolidine-3-carboxylic acid
CAS 1823413-04-2C26H23NO4
5-(4-Chlorophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid chemical structure, C26H22ClNO4, CAS 2171788-21-7
5-(4-Chlorophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
CAS 2171788-21-7C26H22ClNO4
1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-phenylpyrrolidine-2-carboxylic acid chemical structure, C26H23NO4, CAS 2219369-13-6
1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-phenylpyrrolidine-2-carboxylic acid
CAS 2219369-13-6C26H23NO4
(2R,5R)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-5-(4-methoxyphenyl)pyrrolidine-2-carboxylic acid chemical structure, C27H25NO5, CAS 2580100-79-2
(2R,5R)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-5-(4-methoxyphenyl)pyrrolidine-2-carboxylic acid
CAS 2580100-79-2C27H25NO5
(2S,5S)-5-(3-Bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid chemical structure, C26H22BrNO4, CAS 2580096-21-3
(2S,5S)-5-(3-Bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
CAS 2580096-21-3C26H22BrNO4
(2R,5S)-5-(4-Bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid chemical structure, C26H22BrNO4, CAS 2580095-87-8
(2R,5S)-5-(4-Bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
CAS 2580095-87-8C26H22BrNO4
(2S,5R)-5-(4-Bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid chemical structure, C26H22BrNO4, CAS 2580096-25-7
(2S,5R)-5-(4-Bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
CAS 2580096-25-7C26H22BrNO4
4-(1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidin-2-yl)benzoic acid chemical structure, C26H23NO4, CAS 2418606-86-5
4-(1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidin-2-yl)benzoic acid
CAS 2418606-86-5C26H23NO4
rac-(9H-Fluoren-9-yl)methyl (2R,3R)-2-(4-chlorophenyl)-3-hydroxypyrrolidine-1-carboxylate chemical structure, C25H22ClNO3, CAS 2763905-91-3
rac-(9H-Fluoren-9-yl)methyl (2R,3R)-2-(4-chlorophenyl)-3-hydroxypyrrolidine-1-carboxylate
CAS 2763905-91-3C25H22ClNO3