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Murcko scaffold

1-Benzylpiperazin-2-one scaffold

91 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
91
With full pages
3
Scaffold SMILES

O=C1CNCCN1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzylpiperazin-2-one page
Murcko scaffold O=C1CNCCN1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 91 chemicals

1-Benzylpiperazin-2-one chemical structure, C11H14N2O, CAS 59702-21-5
1-Benzylpiperazin-2-one
CAS 59702-21-5C11H14N2O
(R)-1-Benzyl-5-methylpiperazin-2-one chemical structure, C12H16N2O, CAS 301541-47-9
(R)-1-Benzyl-5-methylpiperazin-2-one
CAS 301541-47-9C12H16N2O
tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate chemical structure, C16H22N2O3, CAS 78551-60-7
tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate
CAS 78551-60-7C16H22N2O3
(3R,5R)-1-Benzyl-3,5-dimethylpiperazin-2-one chemical structure, C13H18N2O, CAS 162240-92-8
(3R,5R)-1-Benzyl-3,5-dimethylpiperazin-2-one
CAS 162240-92-8C13H18N2O
(3S)-1-[(4-Fluorophenyl)methyl]-3-(2-methylpropyl)piperazin-2-one chemical structure, C15H21FN2O, CAS 500782-66-1
(3S)-1-[(4-Fluorophenyl)methyl]-3-(2-methylpropyl)piperazin-2-one
CAS 500782-66-1C15H21FN2O
(3S,5S)-1-Benzyl-3,5-dimethylpiperazin-2-one chemical structure, C13H18N2O, CAS 170211-02-6
(3S,5S)-1-Benzyl-3,5-dimethylpiperazin-2-one
CAS 170211-02-6C13H18N2O
Ethyl 2-(4-benzyl-3-oxo-2-piperazinyl)acetate chemical structure, C15H20N2O3, CAS 56926-24-0
Ethyl 2-(4-benzyl-3-oxo-2-piperazinyl)acetate
CAS 56926-24-0C15H20N2O3
1-Benzylpiperazin-2-one hydrochloride chemical structure, C11H15ClN2O, CAS 78551-58-3
1-Benzylpiperazin-2-one hydrochloride
CAS 78551-58-3C11H15ClN2O
Ethyl 4-benzyl-3-oxopiperazine-2-carboxylate chemical structure, C14H18N2O3, CAS 149648-71-5
Ethyl 4-benzyl-3-oxopiperazine-2-carboxylate
CAS 149648-71-5C14H18N2O3
4-(2-Oxopiperazin-1-ylmethyl)benzamidine chemical structure, C12H16N4O, CAS 234098-81-8
4-(2-Oxopiperazin-1-ylmethyl)benzamidine
CAS 234098-81-8C12H16N4O
tert-Butyl 4-[(3-hydroxyphenyl)methyl]-3-oxopiperazine-1-carboxylate chemical structure, C16H22N2O4, CAS 1139877-21-6
tert-Butyl 4-[(3-hydroxyphenyl)methyl]-3-oxopiperazine-1-carboxylate
CAS 1139877-21-6C16H22N2O4
1-[(3-Hydroxyphenyl)methyl]piperazin-2-one chemical structure, C11H14N2O2, CAS 1140066-75-6
1-[(3-Hydroxyphenyl)methyl]piperazin-2-one
CAS 1140066-75-6C11H14N2O2
1-[(4-Fluorophenyl)methyl]-2-piperazinone hydrochloride (1:1) chemical structure, C11H14ClFN2O, CAS 333992-67-9
1-[(4-Fluorophenyl)methyl]-2-piperazinone hydrochloride (1:1)
CAS 333992-67-9C11H14ClFN2O
1-(4-Fluorobenzyl)piperazin-2-one chemical structure, C11H13FN2O, CAS 309915-37-5
1-(4-Fluorobenzyl)piperazin-2-one
CAS 309915-37-5C11H13FN2O
1-(1-Phenylethyl)piperazin-2-one chemical structure, C12H16N2O, CAS 190953-85-6
1-(1-Phenylethyl)piperazin-2-one
CAS 190953-85-6C12H16N2O
1-(2-Methylbenzyl)piperazin-2-one chemical structure, C12H16N2O, CAS 893747-73-4
1-(2-Methylbenzyl)piperazin-2-one
CAS 893747-73-4C12H16N2O
1-(4-Methoxybenzyl)piperazin-2-one chemical structure, C12H16N2O2, CAS 893747-38-1
1-(4-Methoxybenzyl)piperazin-2-one
CAS 893747-38-1C12H16N2O2
1-[(2-Methoxyphenyl)methyl]piperazin-2-one chemical structure, C12H16N2O2, CAS 893747-77-8
1-[(2-Methoxyphenyl)methyl]piperazin-2-one
CAS 893747-77-8C12H16N2O2
1-(3-Methoxybenzyl)piperazin-2-one chemical structure, C12H16N2O2, CAS 893747-81-4
1-(3-Methoxybenzyl)piperazin-2-one
CAS 893747-81-4C12H16N2O2
1-(2-Fluorobenzyl)piperazin-2-one chemical structure, C11H13FN2O, CAS 893747-85-8
1-(2-Fluorobenzyl)piperazin-2-one
CAS 893747-85-8C11H13FN2O
1-[(3-Fluorophenyl)methyl]piperazin-2-one chemical structure, C11H13FN2O, CAS 893747-89-2
1-[(3-Fluorophenyl)methyl]piperazin-2-one
CAS 893747-89-2C11H13FN2O
1-[(4-Bromophenyl)methyl]piperazin-2-one chemical structure, C11H13BrN2O, CAS 893748-02-2
1-[(4-Bromophenyl)methyl]piperazin-2-one
CAS 893748-02-2C11H13BrN2O
1-[(4-Chlorophenyl)methyl]piperazin-2-one chemical structure, C11H13ClN2O, CAS 701208-33-5
1-[(4-Chlorophenyl)methyl]piperazin-2-one
CAS 701208-33-5C11H13ClN2O
1-[(3-Chlorophenyl)methyl]piperazin-2-one chemical structure, C11H13ClN2O, CAS 701208-30-2
1-[(3-Chlorophenyl)methyl]piperazin-2-one
CAS 701208-30-2C11H13ClN2O