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Murcko scaffold

Ring system with 2 rings and 19 atoms

207 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
19
Chemicals
207
With full pages
45
Scaffold SMILES

O=C(C=Cc1ccccc1)NCCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)NCCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 207 chemicals

3-(4-Hydroxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)prop-2-enimidic acid chemical structure, C17H17NO3, CAS 20375-37-5
3-(4-Hydroxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)prop-2-enimidic acid
CAS 20375-37-5C17H17NO3
(2E)-N-[2-(4-Chlorophenyl)ethyl]-3-(3-nitrophenyl)prop-2-enamide chemical structure, C17H15ClN2O3, CAS 301194-62-7
(2E)-N-[2-(4-Chlorophenyl)ethyl]-3-(3-nitrophenyl)prop-2-enamide
CAS 301194-62-7C17H15ClN2O3
(2E)-3-(2,5-Dimethoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]prop-2-enamide chemical structure, C20H23NO4, CAS 189307-58-2
(2E)-3-(2,5-Dimethoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]prop-2-enamide
CAS 189307-58-2C20H23NO4
3-(2,6-Dichlorophenyl)-N-(2-phenylethyl)acrylamide chemical structure, C17H15Cl2NO, CAS 1164488-24-7
3-(2,6-Dichlorophenyl)-N-(2-phenylethyl)acrylamide
CAS 1164488-24-7C17H15Cl2NO
(2E)-3-Phenyl-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide chemical structure, C17H18N2O3S, CAS 25210-82-6
(2E)-3-Phenyl-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide
CAS 25210-82-6C17H18N2O3S
3-(4-Fluorophenyl)-N-(2-(4-methoxyphenyl)ethyl)-2-propenamide chemical structure, C18H18FNO2, CAS 853347-68-9
3-(4-Fluorophenyl)-N-(2-(4-methoxyphenyl)ethyl)-2-propenamide
CAS 853347-68-9C18H18FNO2
(2E)-N-[2-(4-Methoxyphenyl)ethyl]-3-(4-nitrophenyl)prop-2-enamide chemical structure, C18H18N2O4, CAS 313392-94-8
(2E)-N-[2-(4-Methoxyphenyl)ethyl]-3-(4-nitrophenyl)prop-2-enamide
CAS 313392-94-8C18H18N2O4
2-Cyano-3-(3-fluorophenyl)-N-(2-phenylethyl)prop-2-enamide chemical structure, C18H15FN2O, CAS 309944-19-2
2-Cyano-3-(3-fluorophenyl)-N-(2-phenylethyl)prop-2-enamide
CAS 309944-19-2C18H15FN2O
N-Phenethyl-3-phenyl-acrylamide chemical structure, C17H17NO, CAS 103188-43-8
N-Phenethyl-3-phenyl-acrylamide
CAS 103188-43-8C17H17NO
(2E)-3-(4-Ethoxyphenyl)-N-(2-phenylethyl)prop-2-enamide chemical structure, C19H21NO2, CAS 431074-01-0
(2E)-3-(4-Ethoxyphenyl)-N-(2-phenylethyl)prop-2-enamide
CAS 431074-01-0C19H21NO2
(E)-N-[2-(4-Fluorophenyl)ethyl]-3-(2-nitrophenyl)prop-2-enamide chemical structure, C17H15FN2O3, CAS 600124-10-5
(E)-N-[2-(4-Fluorophenyl)ethyl]-3-(2-nitrophenyl)prop-2-enamide
CAS 600124-10-5C17H15FN2O3
(E)-N-[2-(4-Fluorophenyl)ethyl]-3-(4-nitrophenyl)prop-2-enamide chemical structure, C17H15FN2O3, CAS 599186-18-2
(E)-N-[2-(4-Fluorophenyl)ethyl]-3-(4-nitrophenyl)prop-2-enamide
CAS 599186-18-2C17H15FN2O3
(2E)-3-(2-Nitrophenyl)-N-(2-phenylethyl)prop-2-enamide chemical structure, C17H16N2O3, CAS 524686-58-6
(2E)-3-(2-Nitrophenyl)-N-(2-phenylethyl)prop-2-enamide
CAS 524686-58-6C17H16N2O3
(E)-N-[2-(4-Methoxyphenyl)ethyl]-3-(4-propan-2-ylphenyl)prop-2-enamide chemical structure, C21H25NO2, CAS 461707-14-2
(E)-N-[2-(4-Methoxyphenyl)ethyl]-3-(4-propan-2-ylphenyl)prop-2-enamide
CAS 461707-14-2C21H25NO2
3-(3,4-Dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-2-propenamide chemical structure, C21H25NO5, CAS 69444-90-2
3-(3,4-Dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-2-propenamide
CAS 69444-90-2C21H25NO5
Rubemamine chemical structure, C21H25NO5, CAS 121817-65-0
Rubemamine
CAS 121817-65-0C21H25NO5
(E)-3-(2-Chlorophenyl)-N-[2-(4-fluorophenyl)ethyl]prop-2-enamide chemical structure, C17H15ClFNO, CAS 1164525-10-3
(E)-3-(2-Chlorophenyl)-N-[2-(4-fluorophenyl)ethyl]prop-2-enamide
CAS 1164525-10-3C17H15ClFNO
(2E)-3-(2,4-Dichlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]prop-2-enamide chemical structure, C19H19Cl2NO3, CAS 301229-69-6
(2E)-3-(2,4-Dichlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]prop-2-enamide
CAS 301229-69-6C19H19Cl2NO3
2-Cyano-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-[4-(propan-2-yl)phenyl]prop-2-enamide chemical structure, C23H26N2O3, CAS 464905-22-4
2-Cyano-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-[4-(propan-2-yl)phenyl]prop-2-enamide
CAS 464905-22-4C23H26N2O3
(E)-3-(4-Methoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide chemical structure, C18H20N2O4S, CAS 1164469-05-9
(E)-3-(4-Methoxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide
CAS 1164469-05-9C18H20N2O4S
(E)-3-(4-Nitrophenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide chemical structure, C17H17N3O5S, CAS 599186-10-4
(E)-3-(4-Nitrophenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide
CAS 599186-10-4C17H17N3O5S
(E)-N-[2-(4-Fluorophenyl)ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide chemical structure, C20H22FNO4, CAS 432526-54-0
(E)-N-[2-(4-Fluorophenyl)ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
CAS 432526-54-0C20H22FNO4
(E)-3-(3-Nitrophenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide chemical structure, C17H17N3O5S, CAS 349538-55-2
(E)-3-(3-Nitrophenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide
CAS 349538-55-2C17H17N3O5S
(E)-3-(2-Chlorophenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide chemical structure, C17H17ClN2O3S, CAS 349538-35-8
(E)-3-(2-Chlorophenyl)-N-[2-(4-sulfamoylphenyl)ethyl]prop-2-enamide
CAS 349538-35-8C17H17ClN2O3S