Murcko scaffold
Ring system with 2 rings and 20 atoms
360 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 20
- Chemicals
- 360
- With full pages
- 251
Scaffold SMILES
O=C(NN=Cc1ccccc1)C(=O)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 360 chemicals
![2-[(5-Chloro-2-methylphenyl)amino]-2-oxoacetic acid 2-[(3-methoxyphenyl)methylene]hydrazide chemical structure, C17H16ClN3O3, CAS 339100-70-8](/s/YBFQOKBBKVITDO-UHFFFAOYSA-N.svg)
2-[(5-Chloro-2-methylphenyl)amino]-2-oxoacetic acid 2-[(3-methoxyphenyl)methylene]hydrazide
CAS 339100-70-8C17H16ClN3O3
![2-[(4-Methylphenyl)amino]-2-oxoacetic acid 2-(phenylmethylene)hydrazide chemical structure, C16H15N3O2, CAS 50785-59-6](/s/YGUBIELLRXOKIH-UHFFFAOYSA-N.svg)
2-[(4-Methylphenyl)amino]-2-oxoacetic acid 2-(phenylmethylene)hydrazide
CAS 50785-59-6C16H15N3O2
2-(2-(4-Chlorobenzylidene)hydrazino)-N-(3,4-dichlorophenyl)-2-oxoacetamide
CAS 357267-12-0C15H10Cl3N3O2
N-(4-Bromophenyl)-2-(2-(2-chloro-6-fluorobenzylidene)hydrazineyl)-2-oxoacetamide
CAS 358347-26-9C15H10BrClFN3O2
![N'-[[4-(Diethylamino)-2-hydroxyphenyl]methylideneamino]-N-(2,5-dimethylphenyl)oxamide chemical structure, C21H26N4O3](/s/HQCYTYIUXJHYRP-UHFFFAOYSA-N.svg)
N'-[[4-(Diethylamino)-2-hydroxyphenyl]methylideneamino]-N-(2,5-dimethylphenyl)oxamide
C21H26N4O3
![N'-[(5-Bromo-2-hydroxyphenyl)methylideneamino]-N-[3-(trifluoromethyl)phenyl]oxamide chemical structure, C16H11BrF3N3O3](/s/WEVOHENFLCAGHU-UHFFFAOYSA-N.svg)
N'-[(5-Bromo-2-hydroxyphenyl)methylideneamino]-N-[3-(trifluoromethyl)phenyl]oxamide
C16H11BrF3N3O3
N-(2,5-Dichloro-PH)-2-(2-(4-(dimethylamino)benzylidene)hydrazino)-2-oxoacetamide
CAS 413590-99-5C17H16Cl2N4O2
![N-(2,4-Dimethoxyphenyl)-N'-[(E)-(2-fluorophenyl)methylideneamino]oxamide chemical structure, C17H16FN3O4, CAS 352012-86-3](/s/ZDPYCKWUPRXYIP-VXLYETTFSA-N.svg)
N-(2,4-Dimethoxyphenyl)-N'-[(E)-(2-fluorophenyl)methylideneamino]oxamide
CAS 352012-86-3C17H16FN3O4
![N-(2,5-Dimethoxyphenyl)-2-[(2E)-2-(2-nitrobenzylidene)hydrazinyl]-2-oxoacetamide chemical structure, C17H16N4O6, CAS 5523-71-7](/s/MMDXERSEYCJNDG-VCHYOVAHSA-N.svg)
N-(2,5-Dimethoxyphenyl)-2-[(2E)-2-(2-nitrobenzylidene)hydrazinyl]-2-oxoacetamide
CAS 5523-71-7C17H16N4O6
![N'-[(E)-(2-Nitrophenyl)methylideneamino]-N-phenyloxamide chemical structure, C15H12N4O4, CAS 50785-57-4](/s/BTSDUACQVYCFJO-MHWRWJLKSA-N.svg)
N'-[(E)-(2-Nitrophenyl)methylideneamino]-N-phenyloxamide
CAS 50785-57-4C15H12N4O4
N-(4-Methoxyphenyl)-2-(2-(4-methylbenzylidene)hydrazino)-2-oxoacetamide
CAS 351073-00-2C17H17N3O3
![N-(4-Bromophenyl)-N'-[(E)-(2,4-dimethoxyphenyl)methylideneamino]oxamide chemical structure, C17H16BrN3O4, CAS 352012-51-2](/s/VHMKALCRHDXNPW-VXLYETTFSA-N.svg)
N-(4-Bromophenyl)-N'-[(E)-(2,4-dimethoxyphenyl)methylideneamino]oxamide
CAS 352012-51-2C17H16BrN3O4
2-(2-(4-Methoxybenzylidene)hydrazino)-N-(4-methylphenyl)-2-oxoacetamide
CAS 351443-65-7C17H17N3O3
N-(3-Methoxyphenyl)-2-(2-(2-nitrobenzylidene)hydrazino)-2-oxoacetamide
CAS 53117-87-6C16H14N4O5
![2-[(2E)-2-(4-Bromobenzylidene)hydrazinyl]-N-(4-methylphenyl)-2-oxoacetamide chemical structure, C16H14BrN3O2, CAS 5528-26-7](/s/CZCGKIBIVDIARM-VCHYOVAHSA-N.svg)
2-[(2E)-2-(4-Bromobenzylidene)hydrazinyl]-N-(4-methylphenyl)-2-oxoacetamide
CAS 5528-26-7C16H14BrN3O2
![N'-[(E)-(4-Bromophenyl)methylideneamino]-N-(2-methoxyphenyl)oxamide chemical structure, C16H14BrN3O3, CAS 352012-65-8](/s/KWZKQNCYEVTCHE-VCHYOVAHSA-N.svg)
N'-[(E)-(4-Bromophenyl)methylideneamino]-N-(2-methoxyphenyl)oxamide
CAS 352012-65-8C16H14BrN3O3
![N'-[(E)-(2-Fluorophenyl)methylideneamino]-N-(3-methoxyphenyl)oxamide chemical structure, C16H14FN3O3, CAS 352012-74-9](/s/IRRZFSWXKGKRGP-VCHYOVAHSA-N.svg)
N'-[(E)-(2-Fluorophenyl)methylideneamino]-N-(3-methoxyphenyl)oxamide
CAS 352012-74-9C16H14FN3O3
![N-(3,4-Dimethylphenyl)-N'-[(E)-(3-prop-2-enoxyphenyl)methylideneamino]oxamide chemical structure, C20H21N3O3, CAS 352012-38-5](/s/RCPGZVMFMBIXDP-FYJGNVAPSA-N.svg)
N-(3,4-Dimethylphenyl)-N'-[(E)-(3-prop-2-enoxyphenyl)methylideneamino]oxamide
CAS 352012-38-5C20H21N3O3
![N-(2,5-Dimethoxyphenyl)-N'-[(E)-(2-fluorophenyl)methylideneamino]oxamide chemical structure, C17H16FN3O4, CAS 352012-93-2](/s/XVSNLEJMVIIYRZ-VXLYETTFSA-N.svg)
N-(2,5-Dimethoxyphenyl)-N'-[(E)-(2-fluorophenyl)methylideneamino]oxamide
CAS 352012-93-2C17H16FN3O4
![N'-[(E)-Benzylideneamino]-N-(2,5-dimethoxyphenyl)oxamide chemical structure, C17H17N3O4, CAS 352012-91-0](/s/FBAMCOFSSLOPIG-WOJGMQOQSA-N.svg)
N'-[(E)-Benzylideneamino]-N-(2,5-dimethoxyphenyl)oxamide
CAS 352012-91-0C17H17N3O4
![N'-[(E)-(2,4-Dichlorophenyl)methylideneamino]-N-(2-methoxyphenyl)oxamide chemical structure, C16H13Cl2N3O3, CAS 352012-63-6](/s/OZPCGKUYYINWKU-DJKKODMXSA-N.svg)
N'-[(E)-(2,4-Dichlorophenyl)methylideneamino]-N-(2-methoxyphenyl)oxamide
CAS 352012-63-6C16H13Cl2N3O3
![N-(3-Methoxyphenyl)-N'-[(E)-(4-methoxyphenyl)methylideneamino]oxamide chemical structure, C17H17N3O4, CAS 351073-05-7](/s/MPAGZWACVAUHRI-WOJGMQOQSA-N.svg)
N-(3-Methoxyphenyl)-N'-[(E)-(4-methoxyphenyl)methylideneamino]oxamide
CAS 351073-05-7C17H17N3O4
![N'-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-N-(3-methoxyphenyl)oxamide chemical structure, C18H19N3O5, CAS 351073-06-8](/s/RVFLAOUNSHSCDT-YBFXNURJSA-N.svg)
N'-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-N-(3-methoxyphenyl)oxamide
CAS 351073-06-8C18H19N3O5
![N-(4-Bromophenyl)-N'-[(E)-(2-methoxyphenyl)methylideneamino]oxamide chemical structure, C16H14BrN3O3, CAS 352012-47-6](/s/DDCAGJARVDYLSE-VCHYOVAHSA-N.svg)
N-(4-Bromophenyl)-N'-[(E)-(2-methoxyphenyl)methylideneamino]oxamide
CAS 352012-47-6C16H14BrN3O3
- N-(4-Bromophenyl)-N'-[(E)-(4-methoxyphenyl)methylideneamino]oxamide352012-48-7C16H14BrN3O3
- N'-[(E)-(4-Bromophenyl)methylideneamino]-N-(4-methoxyphenyl)oxamide351443-71-5C16H14BrN3O3
- 2-(2-(4-Nitrobenzylidene)hydrazino)-2-oxo-N-phenylacetamide50785-55-2C15H12N4O4
- N-(4-Chlorophenyl)-N'-[(E)-(4-methoxyphenyl)methylideneamino]oxamide351443-59-9C16H14ClN3O3
- N-(4-Chlorophenyl)-N'-[(E)-(2-methoxyphenyl)methylideneamino]oxamide351443-57-7C16H14ClN3O3
- N-(4-Bromophenyl)-N'-[(E)-(4-ethoxyphenyl)methylideneamino]oxamide352012-49-8C17H16BrN3O3
- N-(4-Chlorophenyl)-N'-[(E)-(4-nitrophenyl)methylideneamino]oxamide351443-56-6C15H11ClN4O4
- N-(2-Methoxyphenyl)-N'-[(E)-(4-propan-2-ylphenyl)methylideneamino]oxamide352012-62-5C19H21N3O3
- N-Phenyl-N'-[(E)-(3-prop-2-enoxyphenyl)methylideneamino]oxamide352012-28-3C18H17N3O3
- N'-[(E)-(2,4-Dimethoxyphenyl)methylideneamino]-N-phenyloxamide352012-30-7C17H17N3O4
- N-(4-Methoxyphenyl)-2-(2-(4-nitrobenzylidene)hydrazino)-2-oxoacetamide50785-64-3C16H14N4O5
- N'-[(E)-(2,4-Dimethoxyphenyl)methylideneamino]-N-(2-methoxyphenyl)oxamide351166-60-4C18H19N3O5
- N'-[(E)-(2,5-Dimethoxyphenyl)methylideneamino]-N-(3,4-dimethylphenyl)oxamide352012-39-6C19H21N3O4
- N-(2-Methoxyphenyl)-N'-[(E)-(2-methoxyphenyl)methylideneamino]oxamide352012-66-9C17H17N3O4
- 2-(2-(3-Methoxybenzylidene)hydrazino)-N-(2-methoxyphenyl)-2-oxoacetamide352012-67-0C17H17N3O4
- N-(4-Chlorophenyl)-2-[(2E)-2-(3,4-dimethoxybenzylidene)hydrazinyl]-2-oxoacetamide351443-60-2C17H16ClN3O4
- N-(4-Methylphenyl)-N'-[(E)-(4-propan-2-ylphenyl)methylideneamino]oxamide351443-68-0C19H21N3O2
- N-(3-Bromophenyl)-N'-[(E)-(4-ethoxyphenyl)methylideneamino]oxamide352012-58-9C17H16BrN3O3
- N-(3-Methoxyphenyl)-N'-[(E)-(4-propan-2-ylphenyl)methylideneamino]oxamide352012-73-8C19H21N3O3
- 2-(2-(2-Methoxybenzylidene)hydrazino)-2-oxo-N-phenylacetamide351443-45-3C16H15N3O3
- 2-(2-(2,4-Dichlorobenzylidene)hydrazino)-N-(4-methoxyphenyl)-2-oxoacetamide305850-67-3C16H13Cl2N3O3
- 2-(2-(4-Fluorobenzylidene)hydrazino)-N-(4-methylphenyl)-2-oxoacetamide351443-63-5C16H14FN3O2
- N'-[(E)-(2-Fluorophenyl)methylideneamino]-N-(4-methoxyphenyl)oxamide351443-70-4C16H14FN3O3
- 2-(2-(4-Methylbenzylidene)hydrazino)-N-(4-methylphenyl)-2-oxoacetamide351443-67-9C17H17N3O2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COc1ccccc1)NN=Cc1ccccc1255 chemicals
O=C(NCNC(=S)Nc1ccccc1)c1ccccc179 chemicals
O=C(C=Cc1ccccc1)NCCc1ccccc145 chemicals
O=C(NCCc1ccccc1)OCc1ccccc142 chemicals
O=C(CCc1ccccc1)NCCc1ccccc138 chemicals
c1ccc(CCCNCCc2ccccc2)cc138 chemicals
O=C(CNc1ccccc1)NN=Cc1ccccc126 chemicals
O=S(=O)(NC=NCCc1ccccc1)c1ccccc126 chemicals
c1ccc(CCNCCOc2ccccc2)cc126 chemicals
O=C(CCCOc1ccccc1)Nc1ccccc121 chemicals
O=C(COc1ccccc1)NCCc1ccccc120 chemicals
O=C(NN=CC=Cc1ccccc1)c1ccccc120 chemicals