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Murcko scaffold

Ring system with 2 rings and 18 atoms

20 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 18
Chemicals: 20
With full pages: 4

Scaffold SMILES

O=C(CNC(=O)c1cccs1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CNC(=O)c1cccs1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

N-[2-(2,5-Dimethoxyanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C15H16N2O4S, CAS 713500-70-0

N-[2-(2,5-Dimethoxyanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 713500-70-0C₁₅H₁₆N₂O₄S

N-[2-(3-Chloro-4-methylanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C14H13ClN2O2S, CAS 717863-45-1

N-[2-(3-Chloro-4-methylanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 717863-45-1C₁₄H₁₃ClN₂O₂S

Methyl 2-{[N-(thiophen-2-ylcarbonyl)glycyl]amino}benzoate chemical structure, C15H14N2O4S, CAS 718601-97-9

Methyl 2-{[N-(thiophen-2-ylcarbonyl)glycyl]amino}benzoate

CAS 718601-97-9C₁₅H₁₄N₂O₄S

N-[2-(3-Chloro-4-methoxyanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C14H13ClN2O3S, CAS 832682-54-9

N-[2-(3-Chloro-4-methoxyanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 832682-54-9C₁₄H₁₃ClN₂O₃S

N-[2-(4-Methylanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C14H14N2O2S, CAS 832679-22-8

N-[2-(4-Methylanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 832679-22-8C₁₄H₁₄N₂O₂S

N-[2-(4-Ethoxyanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C15H16N2O3S, CAS 835891-38-8

N-[2-(4-Ethoxyanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 835891-38-8C₁₅H₁₆N₂O₃S

N-[2-(4-Chloroanilino)-2-oxoethyl]-5-methylthiophene-2-carboxamide chemical structure, C14H13ClN2O2S, CAS 852913-31-6

N-[2-(4-Chloroanilino)-2-oxoethyl]-5-methylthiophene-2-carboxamide

CAS 852913-31-6C₁₄H₁₃ClN₂O₂S

N-[2-(3-Chloro-4-fluoroanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C13H10ClFN2O2S, CAS 1002899-01-5

N-[2-(3-Chloro-4-fluoroanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 1002899-01-5C₁₃H₁₀ClFN₂O₂S

N-[2-(5-Fluoro-2-methylanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C14H13FN2O2S, CAS 1089427-66-6

N-[2-(5-Fluoro-2-methylanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 1089427-66-6C₁₄H₁₃FN₂O₂S

N-{2-[(2,4-Dimethoxyphenyl)amino]-2-oxoethyl}thiophene-2-carboxamide chemical structure, C15H16N2O4S, CAS 923742-01-2

N-{2-[(2,4-Dimethoxyphenyl)amino]-2-oxoethyl}thiophene-2-carboxamide

CAS 923742-01-2C₁₅H₁₆N₂O₄S

N-[1-[[(3-Chloro-4-fluorophenyl)amino]carbonyl]-2-methylpropyl]-2-thiophenecarboxamide chemical structure, C16H16ClFN2O2S, CAS 1104640-07-4

N-[1-[[(3-Chloro-4-fluorophenyl)amino]carbonyl]-2-methylpropyl]-2-thiophenecarboxamide

CAS 1104640-07-4C₁₆H₁₆ClFN₂O₂S

N-(2-{[3-(Methylsulfanyl)phenyl]amino}-2-oxoethyl)thiophene-2-carboxamide chemical structure, C14H14N2O2S2, CAS 1060873-18-8

N-(2-{[3-(Methylsulfanyl)phenyl]amino}-2-oxoethyl)thiophene-2-carboxamide

CAS 1060873-18-8C₁₄H₁₄N₂O₂S₂

N-[2-(2,3-Dimethylanilino)-2-oxoethyl]thiophene-2-carboxamide chemical structure, C15H16N2O2S, CAS 1089464-29-8

N-[2-(2,3-Dimethylanilino)-2-oxoethyl]thiophene-2-carboxamide

CAS 1089464-29-8C₁₅H₁₆N₂O₂S

Ethyl 4-[[3-methyl-2-(thiophene-2-carbonylamino)pentanoyl]amino]benzoate chemical structure, C20H24N2O4S, CAS 334830-28-3

Ethyl 4-[[3-methyl-2-(thiophene-2-carbonylamino)pentanoyl]amino]benzoate

CAS 334830-28-3C₂₀H₂₄N₂O₄S

N-{1-[(3,4-Difluorophenyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide chemical structure, C14H12F2N2O2S, CAS 1266371-71-4

N-{1-[(3,4-Difluorophenyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

CAS 1266371-71-4C₁₄H₁₂F₂N₂O₂S

N-{2-[(2,6-Difluorophenyl)amino]-2-oxoethyl}thiophene-2-carboxamide chemical structure, C13H10F2N2O2S, CAS 1089504-55-1

N-{2-[(2,6-Difluorophenyl)amino]-2-oxoethyl}thiophene-2-carboxamide

CAS 1089504-55-1C₁₃H₁₀F₂N₂O₂S

N-(2-Oxo-2-{[2-(propan-2-yl)phenyl]amino}ethyl)thiophene-2-carboxamide chemical structure, C16H18N2O2S, CAS 1089504-58-4

N-(2-Oxo-2-{[2-(propan-2-yl)phenyl]amino}ethyl)thiophene-2-carboxamide

CAS 1089504-58-4C₁₆H₁₈N₂O₂S

N-{1-[(2-Ethoxyphenyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide chemical structure, C16H18N2O3S, CAS 1266372-62-6

N-{1-[(2-Ethoxyphenyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

CAS 1266372-62-6C₁₆H₁₈N₂O₃S

N-{1-[(2-Methoxy-5-methylphenyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide chemical structure, C16H18N2O3S, CAS 1266374-57-5

N-{1-[(2-Methoxy-5-methylphenyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

CAS 1266374-57-5C₁₆H₁₈N₂O₃S

N-[1-(4-Fluoro-2-methylanilino)-1-oxopropan-2-yl]thiophene-2-carboxamide chemical structure, C15H15FN2O2S, CAS 1266377-37-0

N-[1-(4-Fluoro-2-methylanilino)-1-oxopropan-2-yl]thiophene-2-carboxamide

CAS 1266377-37-0C₁₅H₁₅FN₂O₂S