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Murcko scaffold

Ring system with 2 rings and 15 atoms

55 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
55
With full pages
9
Scaffold SMILES

O=c1cc[nH]c(=O)n1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1cc[nH]c(=O)n1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

Uracil, 3-benzyl-5-bromo-1,6-dimethyl- chemical structure, C13H13BrN2O2, CAS 32000-70-7
Uracil, 3-benzyl-5-bromo-1,6-dimethyl-
CAS 32000-70-7C13H13BrN2O2
Uracil, 3-benzyl-1,6-dimethyl-5-dimethylamino- chemical structure, C15H19N3O2, CAS 32150-51-9
Uracil, 3-benzyl-1,6-dimethyl-5-dimethylamino-
CAS 32150-51-9C15H19N3O2
3-Benzyl-6-methyl-1H-pyrimidine-2,4-dione chemical structure, C12H12N2O2, CAS 25589-18-8
3-Benzyl-6-methyl-1H-pyrimidine-2,4-dione
CAS 25589-18-8C12H12N2O2
Ethyl 3-(3-benzyl-5-fluoro-2,4-dioxopyrimidin-1-yl)propanoate chemical structure, C16H17FN2O4, CAS 431892-51-2
Ethyl 3-(3-benzyl-5-fluoro-2,4-dioxopyrimidin-1-yl)propanoate
CAS 431892-51-2C16H17FN2O4
3-Benzyl-6-chloro-1H-pyrimidine-2,4-dione chemical structure, C11H9ClN2O2, CAS 5759-76-2
3-Benzyl-6-chloro-1H-pyrimidine-2,4-dione
CAS 5759-76-2C11H9ClN2O2
1-Benzyl-6-hydroxy-2-oxo-1,2-dihydro-4-pyrimidinecarboxylic acid chemical structure, C12H10N2O4, CAS 338774-89-3
1-Benzyl-6-hydroxy-2-oxo-1,2-dihydro-4-pyrimidinecarboxylic acid
CAS 338774-89-3C12H10N2O4
6-Chloro-3-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C11H8ClFN2O2, CAS 868143-04-8
6-Chloro-3-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS 868143-04-8C11H8ClFN2O2
3-Benzyl-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile chemical structure, C15H15N3O2, CAS 175203-47-1
3-Benzyl-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
CAS 175203-47-1C15H15N3O2
3-Benzyl-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carbothioamide chemical structure, C15H17N3O2S, CAS 175203-49-3
3-Benzyl-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carbothioamide
CAS 175203-49-3C15H17N3O2S
Uracil, 3-(3-bromo-4-ethoxybenzyl)-5-fluoro- chemical structure, C13H12BrFN2O3, CAS 102613-15-0
Uracil, 3-(3-bromo-4-ethoxybenzyl)-5-fluoro-
CAS 102613-15-0C13H12BrFN2O3
Uracil, 3-(3-bromo-4-methoxybenzyl)-5-fluoro- chemical structure, C12H10BrFN2O3, CAS 102613-16-1
Uracil, 3-(3-bromo-4-methoxybenzyl)-5-fluoro-
CAS 102613-16-1C12H10BrFN2O3
Uracil, 3-(3-bromo-6-methoxybenzyl)-5-fluoro- chemical structure, C12H10BrFN2O3, CAS 102613-17-2
Uracil, 3-(3-bromo-6-methoxybenzyl)-5-fluoro-
CAS 102613-17-2C12H10BrFN2O3
Uracil, 3-(4-butoxy-3-chlorobenzyl)-5-fluoro- chemical structure, C15H16ClFN2O3, CAS 102613-18-3
Uracil, 3-(4-butoxy-3-chlorobenzyl)-5-fluoro-
CAS 102613-18-3C15H16ClFN2O3
Uracil, 3-(3-chloro-4-ethoxybenzyl)-5-fluoro- chemical structure, C13H12ClFN2O3, CAS 102613-21-8
Uracil, 3-(3-chloro-4-ethoxybenzyl)-5-fluoro-
CAS 102613-21-8C13H12ClFN2O3
Uracil, 3-(3-chloro-4-isopropoxybenzyl)-5-fluoro- chemical structure, C14H14ClFN2O3, CAS 102613-22-9
Uracil, 3-(3-chloro-4-isopropoxybenzyl)-5-fluoro-
CAS 102613-22-9C14H14ClFN2O3
Uracil, 3-(3-chloro-4-methoxybenzyl)-5-fluoro- chemical structure, C12H10ClFN2O3, CAS 102613-23-0
Uracil, 3-(3-chloro-4-methoxybenzyl)-5-fluoro-
CAS 102613-23-0C12H10ClFN2O3
Uracil, 3-(3-chloro-4-propoxybenzyl)-5-fluoro- chemical structure, C14H14ClFN2O3, CAS 102613-24-1
Uracil, 3-(3-chloro-4-propoxybenzyl)-5-fluoro-
CAS 102613-24-1C14H14ClFN2O3
2-((3-((2S)-2-Amino-2-carboxyethyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)methyl)benzoic acid chemical structure, C15H15N3O6, CAS 745055-91-8
2-((3-((2S)-2-Amino-2-carboxyethyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)methyl)benzoic acid
CAS 745055-91-8C15H15N3O6
(S)-4-((3-(2-Amino-2-carboxyethyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)methyl)benzoic acid chemical structure, C15H15N3O6, CAS 544697-47-4
(S)-4-((3-(2-Amino-2-carboxyethyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)methyl)benzoic acid
CAS 544697-47-4C15H15N3O6
4-[[3-[(2S)-2-Amino-2-carboxyethyl]-5-iodo-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid chemical structure, C15H14IN3O6, CAS 569371-10-4
4-[[3-[(2S)-2-Amino-2-carboxyethyl]-5-iodo-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid
CAS 569371-10-4C15H14IN3O6
3-Benzyl-N'-hydroxy-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide chemical structure, C15H18N4O3, CAS 175203-48-2
3-Benzyl-N'-hydroxy-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide
CAS 175203-48-2C15H18N4O3
3-Benzyl-5-nitro-1H-pyrimidine-2,4-dione chemical structure, C11H9N3O4, CAS 27889-91-4
3-Benzyl-5-nitro-1H-pyrimidine-2,4-dione
CAS 27889-91-4C11H9N3O4
3-Benzyl-5-methyl-1H-pyrimidine-2,4-dione chemical structure, C12H12N2O2, CAS 21473-22-3
3-Benzyl-5-methyl-1H-pyrimidine-2,4-dione
CAS 21473-22-3C12H12N2O2
3-[(3-Methoxyphenyl)methyl]-5-methyl-1H-pyrimidine-2,4-dione chemical structure, C13H14N2O3, CAS 821795-75-9
3-[(3-Methoxyphenyl)methyl]-5-methyl-1H-pyrimidine-2,4-dione
CAS 821795-75-9C13H14N2O3