Murcko scaffold
Ring system with 3 rings and 16 atoms
7 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 16
- Chemicals
- 7
- With full pages
- 2
Scaffold SMILES
O=C(c1cccs1)c1c[nH]c2ccccc12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(c1cccs1)c1c[nH]c2ccccc12](/scaffold/BVOLLNOZJTUTPD-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 7 of 7 chemicals
Tenidap
CAS 120210-48-2C14H9ClN2O3S
Ilonidap
CAS 135202-79-8C14H8ClFN2O3S
![N-(2-Methoxyethyl)-2-[3-(thiophene-2-carbonyl)indol-1-yl]acetamide chemical structure, C18H18N2O3S, CAS 678191-05-4](/s/SPYVUJSKUUMUCG-UHFFFAOYSA-N.svg)
N-(2-Methoxyethyl)-2-[3-(thiophene-2-carbonyl)indol-1-yl]acetamide
CAS 678191-05-4C18H18N2O3S
1H-Indole-1-carboxamide, 6-chloro-3-((4-chloro-2-thienyl)carbonyl)-5-fluoro-2,3-dihydro-2-oxo-
CAS 172618-05-2C14H7Cl2FN2O3S
(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-N-propyl-1H-indole-1-carboxamide
CAS 351013-97-3C17H15ClN2O3S
Methyl 5-(1H-indole-3-carbonyl)thiophene-3-carboxylate
CAS 2231344-31-1C15H11NO3S
Tenidap-d3
CAS 142741-60-4C14H9ClN2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C1Nc2ccccc2C1=Cc1ccc[nH]1](/scaffold/SEZFNTZQMWJIAI-UHFFFAOYSA-N/structure.svg)
O=C1Nc2ccccc2C1=Cc1ccc[nH]121 chemicals
c1coc(Cn2ccc3ccccc32)c18 chemicals![Scaffold O=c1sc2ccccc2n1Cc1nnc[nH]1](/scaffold/GWFCEOCUCXWORL-UHFFFAOYSA-N/structure.svg)
O=c1sc2ccccc2n1Cc1nnc[nH]17 chemicals![Scaffold O=C1NC(=O)C(Cc2c[nH]c3ccccc23)N1](/scaffold/RUUREKIGAKIKIL-UHFFFAOYSA-N/structure.svg)
O=C1NC(=O)C(Cc2c[nH]c3ccccc23)N17 chemicals![Scaffold O=C(c1ccn[nH]1)N1CCc2ccccc21](/scaffold/FWLCINSTZWDYRW-UHFFFAOYSA-N/structure.svg)
O=C(c1ccn[nH]1)N1CCc2ccccc214 chemicals![Scaffold O=C1NC(=S)NC1Cc1c[nH]c2ccccc12](/scaffold/MPLRRPKKFHUEEL-UHFFFAOYSA-N/structure.svg)
O=C1NC(=S)NC1Cc1c[nH]c2ccccc124 chemicals
O=C1Nc2ccccc2C1=Cc1ccco14 chemicals![Scaffold O=C1Nc2ccccc2C1=Cc1cnc[nH]1](/scaffold/VEEGZPWAAPPXRB-UHFFFAOYSA-N/structure.svg)
O=C1Nc2ccccc2C1=Cc1cnc[nH]14 chemicals![Scaffold O=C(c1nccs1)c1c[nH]c2ccccc12](/scaffold/DFYPIVYFSGGXGT-UHFFFAOYSA-N/structure.svg)
O=C(c1nccs1)c1c[nH]c2ccccc123 chemicals![Scaffold O=c1[nH]cnc2c(Cc3ccsc3)c[nH]c12](/scaffold/DZRJGBKWVIJPOL-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cnc2c(Cc3ccsc3)c[nH]c123 chemicals![Scaffold c1ccc2c(Cn3ccnc3)c[nH]c2c1](/scaffold/FRADTKAUXQUOIJ-UHFFFAOYSA-N/structure.svg)
c1ccc2c(Cn3ccnc3)c[nH]c2c13 chemicals![Scaffold c1ccc2c(Cc3nncs3)c[nH]c2c1](/scaffold/ISZUDSQKNRXVPO-UHFFFAOYSA-N/structure.svg)
c1ccc2c(Cc3nncs3)c[nH]c2c13 chemicals