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Murcko scaffold

Ring system with 3 rings and 22 atoms

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
20
With full pages
2
Scaffold SMILES

O=C1NC(=O)C(=Cc2ccccc2OCc2ccccc2)S1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=O)C(=Cc2ccccc2OCc2ccccc2)S1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

5-(2-Benzyloxy-benzylidene)-thiazolidine-2,4-dione chemical structure, C17H13NO3S, CAS 292172-33-9
5-(2-Benzyloxy-benzylidene)-thiazolidine-2,4-dione
CAS 292172-33-9C17H13NO3S
Methyl [(5E)-5-{5-bromo-2-[(3-methylbenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate chemical structure, C21H18BrNO5S, CAS 690685-85-9
Methyl [(5E)-5-{5-bromo-2-[(3-methylbenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
CAS 690685-85-9C21H18BrNO5S
(5E)-5-[[2-[(4-Methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione chemical structure, C21H17NO3S, CAS 432016-03-0
(5E)-5-[[2-[(4-Methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione
CAS 432016-03-0C21H17NO3S
4-({2-Methoxy-6-[(3-methyl-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}methyl)benzoic acid chemical structure, C20H17NO6S, CAS 433328-48-4
4-({2-Methoxy-6-[(3-methyl-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}methyl)benzoic acid
CAS 433328-48-4C20H17NO6S
Methyl [(5E)-5-{5-bromo-2-[(2-chlorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate chemical structure, C20H15BrClNO5S, CAS 593272-31-2
Methyl [(5E)-5-{5-bromo-2-[(2-chlorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
CAS 593272-31-2C20H15BrClNO5S
3-({2-[(E)-(3-Ethyl-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-6-methoxyphenoxy}methyl)benzoic acid chemical structure, C21H19NO6S, CAS 692267-32-6
3-({2-[(E)-(3-Ethyl-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-6-methoxyphenoxy}methyl)benzoic acid
CAS 692267-32-6C21H19NO6S
(5E)-5-[[2-[(4-Iodophenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione chemical structure, C20H14INO3S, CAS 431929-31-6
(5E)-5-[[2-[(4-Iodophenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione
CAS 431929-31-6C20H14INO3S
Ethyl [(5E)-5-{2-[(3-nitrobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate chemical structure, C21H18N2O7S, CAS 431932-10-4
Ethyl [(5E)-5-{2-[(3-nitrobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
CAS 431932-10-4C21H18N2O7S
(5Z)-5-[[2-[(4-Chlorophenyl)methoxy]phenyl]methylidene]-3-methyl-1,3-thiazolidine-2,4-dione chemical structure, C18H14ClNO3S, CAS 366832-00-0
(5Z)-5-[[2-[(4-Chlorophenyl)methoxy]phenyl]methylidene]-3-methyl-1,3-thiazolidine-2,4-dione
CAS 366832-00-0C18H14ClNO3S
(5Z)-5-{2-[(4-Iodobenzyl)oxy]benzylidene}-3-methyl-1,3-thiazolidine-2,4-dione chemical structure, C18H14INO3S, CAS 367456-88-0
(5Z)-5-{2-[(4-Iodobenzyl)oxy]benzylidene}-3-methyl-1,3-thiazolidine-2,4-dione
CAS 367456-88-0C18H14INO3S
(5E)-5-[[5-Bromo-2-[(2-chlorophenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione chemical structure, C20H13BrClNO3S, CAS 432019-27-7
(5E)-5-[[5-Bromo-2-[(2-chlorophenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione
CAS 432019-27-7C20H13BrClNO3S
Ethyl [(5E)-5-{5-bromo-2-[(2-fluorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate chemical structure, C21H17BrFNO5S, CAS 431991-69-4
Ethyl [(5E)-5-{5-bromo-2-[(2-fluorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
CAS 431991-69-4C21H17BrFNO5S
4-[(2-{(E)-[2,4-Dioxo-3-(prop-2-yn-1-yl)-1,3-thiazolidin-5-ylidene]methyl}phenoxy)methyl]benzoic acid chemical structure, C21H15NO5S, CAS 432503-78-1
4-[(2-{(E)-[2,4-Dioxo-3-(prop-2-yn-1-yl)-1,3-thiazolidin-5-ylidene]methyl}phenoxy)methyl]benzoic acid
CAS 432503-78-1C21H15NO5S
Ethyl [(5E)-5-{2-[(4-chlorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate chemical structure, C21H18ClNO5S, CAS 432539-33-8
Ethyl [(5E)-5-{2-[(4-chlorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
CAS 432539-33-8C21H18ClNO5S
5-[[2-[(4-Methylphenyl)methoxy]phenyl]methylene]-2,4-thiazolidinedione chemical structure, C18H15NO3S, CAS 319452-63-6
5-[[2-[(4-Methylphenyl)methoxy]phenyl]methylene]-2,4-thiazolidinedione
CAS 319452-63-6C18H15NO3S
(5Z)-5-({5-Bromo-2-[(2-fluorophenyl)methoxy]phenyl}methylidene)-3-methyl-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrFNO3S, CAS 6350-34-1
(5Z)-5-({5-Bromo-2-[(2-fluorophenyl)methoxy]phenyl}methylidene)-3-methyl-1,3-thiazolidine-2,4-dione
CAS 6350-34-1C18H13BrFNO3S
(5E)-5-[[2-[(4-Nitrophenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione chemical structure, C20H14N2O5S, CAS 432001-34-8
(5E)-5-[[2-[(4-Nitrophenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione
CAS 432001-34-8C20H14N2O5S
(5E)-5-[[5-Bromo-2-[(3-methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione chemical structure, C21H16BrNO3S, CAS 431999-41-6
(5E)-5-[[5-Bromo-2-[(3-methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione
CAS 431999-41-6C21H16BrNO3S
Methyl 2-[(5E)-5-{2-[(2-fluorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate chemical structure, C21H18FNO5S, CAS 643746-20-7
Methyl 2-[(5E)-5-{2-[(2-fluorobenzyl)oxy]benzylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
CAS 643746-20-7C21H18FNO5S
4-[(2-{(E)-[3-(1-Methoxy-1-oxopropan-2-yl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)methyl]benzoic acid chemical structure, C22H19NO7S, CAS 1084610-35-4
4-[(2-{(E)-[3-(1-Methoxy-1-oxopropan-2-yl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)methyl]benzoic acid
CAS 1084610-35-4C22H19NO7S