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Murcko scaffold

Ring system with 3 rings and 22 atoms

21 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 21
With full pages: 1

Scaffold SMILES

O=C1NC(=S)SC1=Cc1ccccc1OCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(=S)SC1=Cc1ccccc1OCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

5-[[5-Chloro-2-[(2-nitrophenyl)methoxy]phenyl]methylene]-3-methyl-2-thioxo-4-thiazolidinone chemical structure, C18H13ClN2O4S2, CAS 690646-15-2

5-[[5-Chloro-2-[(2-nitrophenyl)methoxy]phenyl]methylene]-3-methyl-2-thioxo-4-thiazolidinone

CAS 690646-15-2C₁₈H₁₃ClN₂O₄S₂

4-({2-[(E)-(4-Oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}methyl)benzoic acid chemical structure, C18H13NO4S2, CAS 428482-30-8

4-({2-[(E)-(4-Oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}methyl)benzoic acid

CAS 428482-30-8C₁₈H₁₃NO₄S₂

5-{[2-(Benzyloxy)-5-chlorophenyl]methylidene}-3-(prop-2-en-1-yl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H16ClNO2S2, CAS 4355-42-4

5-{[2-(Benzyloxy)-5-chlorophenyl]methylidene}-3-(prop-2-en-1-yl)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 4355-42-4C₂₀H₁₆ClNO₂S₂

(5Z)-5-({2-[(3-Chlorophenyl)methoxy]-5-nitrophenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C17H11ClN2O4S2, CAS 622354-45-4

(5Z)-5-({2-[(3-Chlorophenyl)methoxy]-5-nitrophenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 622354-45-4C₁₇H₁₁ClN₂O₄S₂

(5Z)-5-({2-[(2-Methylphenyl)methoxy]-5-nitrophenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C18H14N2O4S2, CAS 622354-49-8

(5Z)-5-({2-[(2-Methylphenyl)methoxy]-5-nitrophenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 622354-49-8C₁₈H₁₄N₂O₄S₂

(5Z)-5-({2-[(3-Methylphenyl)methoxy]-5-nitrophenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C18H14N2O4S2, CAS 622354-41-0

(5Z)-5-({2-[(3-Methylphenyl)methoxy]-5-nitrophenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 622354-41-0C₁₈H₁₄N₂O₄S₂

(Z)-2-(5-(2-((2-Chlorobenzyl)oxy)-5-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid chemical structure, C19H13ClN2O6S2, CAS 613218-85-2

(Z)-2-(5-(2-((2-Chlorobenzyl)oxy)-5-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

CAS 613218-85-2C₁₉H₁₃ClN₂O₆S₂

(Z)-3-(5-(2-((2-Chlorobenzyl)oxy)-5-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid chemical structure, C20H15ClN2O6S2, CAS 613218-87-4

(Z)-3-(5-(2-((2-Chlorobenzyl)oxy)-5-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid

CAS 613218-87-4C₂₀H₁₅ClN₂O₆S₂

5-{2-[(2,4-Dichlorobenzyl)oxy]benzylidene}-3-ethyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H15Cl2NO2S2, CAS 292076-25-6

5-{2-[(2,4-Dichlorobenzyl)oxy]benzylidene}-3-ethyl-2-thioxo-1,3-thiazolidin-4-one

CAS 292076-25-6C₁₉H₁₅Cl₂NO₂S₂

(5E)-5-{2-[(4-Nitrobenzyl)oxy]benzylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H12N2O4S2, CAS 5529-17-9

(5E)-5-{2-[(4-Nitrobenzyl)oxy]benzylidene}-2-thioxo-1,3-thiazolidin-4-one

CAS 5529-17-9C₁₇H₁₂N₂O₄S₂

(5Z)-5-[[2-[(2-Chlorophenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H16ClNO2S2, CAS 5734-23-6

(5Z)-5-[[2-[(2-Chlorophenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 5734-23-6C₂₀H₁₆ClNO₂S₂

(5E)-5-({5-Bromo-2-[(2-chlorophenyl)methoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C17H11BrClNO2S2, CAS 6172-72-1

(5E)-5-({5-Bromo-2-[(2-chlorophenyl)methoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 6172-72-1C₁₇H₁₁BrClNO₂S₂

(5E)-5-{2-[(4-Chlorobenzyl)oxy]benzylidene}-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H16ClNO2S2, CAS 6186-49-8

(5E)-5-{2-[(4-Chlorobenzyl)oxy]benzylidene}-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one

CAS 6186-49-8C₂₀H₁₆ClNO₂S₂

5-{2-[(4-Chlorobenzyl)oxy]benzylidene}-3-methyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H14ClNO2S2, CAS 6188-05-2

5-{2-[(4-Chlorobenzyl)oxy]benzylidene}-3-methyl-2-thioxo-1,3-thiazolidin-4-one

CAS 6188-05-2C₁₈H₁₄ClNO₂S₂

(5E)-5-[[5-Chloro-2-[(2-fluorophenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H15ClFNO2S2, CAS 6193-21-1

(5E)-5-[[5-Chloro-2-[(2-fluorophenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 6193-21-1C₂₀H₁₅ClFNO₂S₂

5-[[5-Bromo-2-[(4-methylphenyl)methoxy]phenyl]methylene]-3-(2-propen-1-yl)-2-thioxo-4-thiazolidinone chemical structure, C21H18BrNO2S2, CAS 429649-93-4

5-[[5-Bromo-2-[(4-methylphenyl)methoxy]phenyl]methylene]-3-(2-propen-1-yl)-2-thioxo-4-thiazolidinone

CAS 429649-93-4C₂₁H₁₈BrNO₂S₂

(5E)-5-[[2-[(2,4-Dichlorophenyl)methoxy]-4-(diethylamino)phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H20Cl2N2O2S2, CAS 292172-71-5

(5E)-5-[[2-[(2,4-Dichlorophenyl)methoxy]-4-(diethylamino)phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 292172-71-5C₂₁H₂₀Cl₂N₂O₂S₂

PRL-3 inhibitor I chemical structure, C17H11Br2NO2S2, CAS 893449-38-2

PRL-3 inhibitor I

CAS 893449-38-2C₁₇H₁₁Br₂NO₂S₂

(5Z)-5-{[2-(Benzyloxy)-3-methoxyphenyl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C18H15NO3S2, CAS 1287651-60-8

(5Z)-5-{[2-(Benzyloxy)-3-methoxyphenyl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 1287651-60-8C₁₈H₁₅NO₃S₂

3-(2-Methoxyethyl)-5-[[2-(phenylmethoxy)phenyl]methylene]-2-thioxo-4-thiazolidinone chemical structure, C20H19NO3S2, CAS 933672-31-2

3-(2-Methoxyethyl)-5-[[2-(phenylmethoxy)phenyl]methylene]-2-thioxo-4-thiazolidinone

CAS 933672-31-2C₂₀H₁₉NO₃S₂

3-(3-Methoxypropyl)-5-[[2-[(4-methylphenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone chemical structure, C22H23NO3S2, CAS 933671-88-6

3-(3-Methoxypropyl)-5-[[2-[(4-methylphenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone

CAS 933671-88-6C₂₂H₂₃NO₃S₂