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Murcko scaffold

Ring system with 4 rings and 25 atoms

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
7
With full pages
1
Scaffold SMILES

O=C(Cc1cccc2ccccc12)Nc1nc(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1cccc2ccccc12)Nc1nc(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(naphthalen-1-yl)acetamide chemical structure, C23H20N2O3S, CAS 476210-48-7
N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(naphthalen-1-yl)acetamide
CAS 476210-48-7C23H20N2O3S
N-(4-(4-Ethylphenyl)thiazol-2-yl)-2-(naphthalen-1-yl)acetamide chemical structure, C23H20N2OS, CAS 324758-36-3
N-(4-(4-Ethylphenyl)thiazol-2-yl)-2-(naphthalen-1-yl)acetamide
CAS 324758-36-3C23H20N2OS
N-(5-Acetyl-4-phenyl-1,3-thiazol-2-yl)-2-naphthalen-1-ylacetamide chemical structure, C23H18N2O2S, CAS 328539-75-9
N-(5-Acetyl-4-phenyl-1,3-thiazol-2-yl)-2-naphthalen-1-ylacetamide
CAS 328539-75-9C23H18N2O2S
N-(4-Mesitylthiazol-2-yl)-2-(naphthalen-1-yl)acetamide chemical structure, C24H22N2OS, CAS 324758-37-4
N-(4-Mesitylthiazol-2-yl)-2-(naphthalen-1-yl)acetamide
CAS 324758-37-4C24H22N2OS
N-(4-(2,5-Dichlorophenyl)thiazol-2-yl)-2-(naphthalen-1-yl)acetamide chemical structure, C21H14Cl2N2OS, CAS 391228-67-4
N-(4-(2,5-Dichlorophenyl)thiazol-2-yl)-2-(naphthalen-1-yl)acetamide
CAS 391228-67-4C21H14Cl2N2OS
N-(4-(2,4-Dimethoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-yl)acetamide chemical structure, C23H20N2O3S, CAS 476628-54-3
N-(4-(2,4-Dimethoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-yl)acetamide
CAS 476628-54-3C23H20N2O3S
2-(Naphthalen-1-yl)-N-(4-(3-nitrophenyl)thiazol-2-yl)acetamide chemical structure, C21H15N3O3S, CAS 391221-56-0
2-(Naphthalen-1-yl)-N-(4-(3-nitrophenyl)thiazol-2-yl)acetamide
CAS 391221-56-0C21H15N3O3S