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Murcko scaffold

1,4-Bis(phenoxyacetyl)piperazine scaffold

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
29
With full pages
9
Scaffold SMILES

O=C(COc1ccccc1)N1CCN(C(=O)COc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Bis(phenoxyacetyl)piperazine page
Murcko scaffold O=C(COc1ccccc1)N1CCN(C(=O)COc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

Simetride chemical structure, C28H38N2O6, CAS 154-82-5
Simetride
CAS 154-82-5C28H38N2O6
Piperazine, 1,4-bis((4-methoxyphenoxy)acetyl)- chemical structure, C22H26N2O6, CAS 2882-23-7
Piperazine, 1,4-bis((4-methoxyphenoxy)acetyl)-
CAS 2882-23-7C22H26N2O6
Piperazine, 1,4-bis((2-methoxyphenoxy)acetyl)- chemical structure, C22H26N2O6, CAS 2884-28-8
Piperazine, 1,4-bis((2-methoxyphenoxy)acetyl)-
CAS 2884-28-8C22H26N2O6
1,4-Bis((2,4-dichlorophenoxy)acetyl)piperazine chemical structure, C20H18Cl4N2O4, CAS 4199-71-7
1,4-Bis((2,4-dichlorophenoxy)acetyl)piperazine
CAS 4199-71-7C20H18Cl4N2O4
1,4-Bis(phenoxyacetyl)piperazine chemical structure, C20H22N2O4, CAS 1784-10-7
1,4-Bis(phenoxyacetyl)piperazine
CAS 1784-10-7C20H22N2O4
1,4-Bis((m-tolyloxy)acetyl)piperazine chemical structure, C22H26N2O4, CAS 2884-12-0
1,4-Bis((m-tolyloxy)acetyl)piperazine
CAS 2884-12-0C22H26N2O4
Piperazine, 1,4-bis((2,5-dimethylphenoxy)acetyl)- chemical structure, C24H30N2O4, CAS 143189-97-3
Piperazine, 1,4-bis((2,5-dimethylphenoxy)acetyl)-
CAS 143189-97-3C24H30N2O4
1,4-Bis[(4-ethylphenoxy)acetyl]piperazine chemical structure, C24H30N2O4, CAS 3079-97-8
1,4-Bis[(4-ethylphenoxy)acetyl]piperazine
CAS 3079-97-8C24H30N2O4
1,4-Bis[(2-isopropylphenoxy)acetyl]piperazine chemical structure, C26H34N2O4, CAS 606923-56-2
1,4-Bis[(2-isopropylphenoxy)acetyl]piperazine
CAS 606923-56-2C26H34N2O4
2-(4-Chlorophenoxy)-1-[4-[2-(3-methylphenoxy)acetyl]piperazin-1-yl]ethanone chemical structure, C21H23ClN2O4, CAS 423733-69-1
2-(4-Chlorophenoxy)-1-[4-[2-(3-methylphenoxy)acetyl]piperazin-1-yl]ethanone
CAS 423733-69-1C21H23ClN2O4
1-[4-[2-(3-Methylphenoxy)acetyl]piperazin-1-yl]-2-phenoxyethanone chemical structure, C21H24N2O4, CAS 423739-12-2
1-[4-[2-(3-Methylphenoxy)acetyl]piperazin-1-yl]-2-phenoxyethanone
CAS 423739-12-2C21H24N2O4
1-[(4-Methoxyphenoxy)acetyl]-4-(phenoxyacetyl)piperazine chemical structure, C21H24N2O5, CAS 497245-20-2
1-[(4-Methoxyphenoxy)acetyl]-4-(phenoxyacetyl)piperazine
CAS 497245-20-2C21H24N2O5
2-(4-Fluorophenoxy)-1-{4-[2-(4-fluorophenoxy)acetyl]piperazin-1-yl}ethan-1-one chemical structure, C20H20F2N2O4, CAS 380188-86-3
2-(4-Fluorophenoxy)-1-{4-[2-(4-fluorophenoxy)acetyl]piperazin-1-yl}ethan-1-one
CAS 380188-86-3C20H20F2N2O4
Piperazine, 1,4-bis((2,4-dimethylphenoxy)acetyl)- chemical structure, C24H30N2O4, CAS 143189-96-2
Piperazine, 1,4-bis((2,4-dimethylphenoxy)acetyl)-
CAS 143189-96-2C24H30N2O4
2-(4-Chloro-3-methylphenoxy)-1-[4-[2-(4-chloro-3-methylphenoxy)acetyl]piperazin-1-yl]ethanone chemical structure, C22H24Cl2N2O4, CAS 650615-41-1
2-(4-Chloro-3-methylphenoxy)-1-[4-[2-(4-chloro-3-methylphenoxy)acetyl]piperazin-1-yl]ethanone
CAS 650615-41-1C22H24Cl2N2O4
1-[4-[2-(4-Bromophenoxy)acetyl]piperazin-1-yl]-2-(4-methylphenoxy)ethanone chemical structure, C21H23BrN2O4, CAS 423751-55-7
1-[4-[2-(4-Bromophenoxy)acetyl]piperazin-1-yl]-2-(4-methylphenoxy)ethanone
CAS 423751-55-7C21H23BrN2O4
1,4-Bis[(3,5-dimethylphenoxy)acetyl]piperazine chemical structure, C24H30N2O4, CAS 358351-11-8
1,4-Bis[(3,5-dimethylphenoxy)acetyl]piperazine
CAS 358351-11-8C24H30N2O4
1,4-Bis-[(4-chloro-phenoxy)-acetyl]-piperazine chemical structure, C20H20Cl2N2O4, CAS 4190-83-4
1,4-Bis-[(4-chloro-phenoxy)-acetyl]-piperazine
CAS 4190-83-4C20H20Cl2N2O4
Piperazine, 1-[(4-bromophenoxy)acetyl]-4-[(3-methylphenoxy)acetyl]- chemical structure, C21H23BrN2O4, CAS 423736-21-4
Piperazine, 1-[(4-bromophenoxy)acetyl]-4-[(3-methylphenoxy)acetyl]-
CAS 423736-21-4C21H23BrN2O4
1,4-Bis((o-chlorophenoxy)acetyl)piperazine chemical structure, C20H20Cl2N2O4, CAS 1784-11-8
1,4-Bis((o-chlorophenoxy)acetyl)piperazine
CAS 1784-11-8C20H20Cl2N2O4
2-Phenoxy-1-[4-(2-phenoxybutanoyl)piperazin-1-yl]butan-1-one chemical structure, C24H30N2O4, CAS 418786-99-9
2-Phenoxy-1-[4-(2-phenoxybutanoyl)piperazin-1-yl]butan-1-one
CAS 418786-99-9C24H30N2O4
1-[4-[2-(4-Methoxyphenoxy)acetyl]piperazin-1-yl]-2-(4-methylphenoxy)ethanone chemical structure, C22H26N2O5, CAS 423735-58-4
1-[4-[2-(4-Methoxyphenoxy)acetyl]piperazin-1-yl]-2-(4-methylphenoxy)ethanone
CAS 423735-58-4C22H26N2O5
1-[4-[2-(4-Chlorophenoxy)acetyl]piperazin-1-yl]-2-(4-methylphenoxy)ethanone chemical structure, C21H23ClN2O4, CAS 423753-25-7
1-[4-[2-(4-Chlorophenoxy)acetyl]piperazin-1-yl]-2-(4-methylphenoxy)ethanone
CAS 423753-25-7C21H23ClN2O4
1,4-Bis[2-(4-methylphenoxy)propanoyl]piperazine chemical structure, C24H30N2O4, CAS 817635-00-0
1,4-Bis[2-(4-methylphenoxy)propanoyl]piperazine
CAS 817635-00-0C24H30N2O4