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Murcko scaffold

Ring system with 3 rings and 26 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
14
With full pages
3
Scaffold SMILES

O=C(Nc1ccccc1)Nc1ccc(NC(=O)Nc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)Nc1ccc(NC(=O)Nc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

1,1'-(1,4-Phenylene)bis(3-(3-chlorophenyl)urea) chemical structure, C20H16Cl2N4O2, CAS 392708-65-5
1,1'-(1,4-Phenylene)bis(3-(3-chlorophenyl)urea)
CAS 392708-65-5C20H16Cl2N4O2
1-(4-Chloro-phenyl)-3-(4-(3-(4-chloro-phenyl)-ureido)-phenyl)-urea chemical structure, C20H16Cl2N4O2, CAS 132571-96-1
1-(4-Chloro-phenyl)-3-(4-(3-(4-chloro-phenyl)-ureido)-phenyl)-urea
CAS 132571-96-1C20H16Cl2N4O2
3,3'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N,N'-dimethylbenzene-1-carboximidamide)--hydrogen chloride (1/1) chemical structure, C26H31ClN8O2, CAS 5971-20-0
3,3'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N,N'-dimethylbenzene-1-carboximidamide)--hydrogen chloride (1/1)
CAS 5971-20-0C26H31ClN8O2
4,4'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N-butyl-N'-methylbenzene-1-carboximidamide)--hydrogen chloride (1/1) chemical structure, C32H43ClN8O2, CAS 5300-45-8
4,4'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N-butyl-N'-methylbenzene-1-carboximidamide)--hydrogen chloride (1/1)
CAS 5300-45-8C32H43ClN8O2
Urea,1'-p-phenylenebis[3-[p-[N-(3-methoxypropyl)-N'-methylamidino]phenyl]-, dihydrochloride, hydrate chemical structure, C32H43ClN8O4, CAS 27930-62-7
Urea,1'-p-phenylenebis[3-[p-[N-(3-methoxypropyl)-N'-methylamidino]phenyl]-, dihydrochloride, hydrate
CAS 27930-62-7C32H43ClN8O4
4,4'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N'-ethylbenzene-1-carboximidamide)--hydrogen chloride (1/1) chemical structure, C26H31ClN8O2, CAS 25775-32-0
4,4'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N'-ethylbenzene-1-carboximidamide)--hydrogen chloride (1/1)
CAS 25775-32-0C26H31ClN8O2
Urea,1'-p-phenylenebis[3-[p-(3-methylguanidino)phenyl]-, dihydrochloride chemical structure, C24H29ClN10O2, CAS 25775-33-1
Urea,1'-p-phenylenebis[3-[p-(3-methylguanidino)phenyl]-, dihydrochloride
CAS 25775-33-1C24H29ClN10O2
4,4'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N,N'-dimethylbenzene-1-carboximidamide)--hydrogen chloride (1/1) chemical structure, C26H31ClN8O2, CAS 5300-44-7
4,4'-[1,4-Phenylenebis(carbamoylazanediyl)]bis(N,N'-dimethylbenzene-1-carboximidamide)--hydrogen chloride (1/1)
CAS 5300-44-7C26H31ClN8O2
Urea,1'-p-phenylenebis[3-[p-(2,3-diethylguanidino)phenyl]-, dihydrochloride, dihydrate chemical structure, C30H41ClN10O2, CAS 38591-31-0
Urea,1'-p-phenylenebis[3-[p-(2,3-diethylguanidino)phenyl]-, dihydrochloride, dihydrate
CAS 38591-31-0C30H41ClN10O2
Urea,1'-p-phenylenebis[3-[p-(methylamidino)phenyl]-, dihydrochloride chemical structure, C24H27ClN8O2, CAS 25787-03-5
Urea,1'-p-phenylenebis[3-[p-(methylamidino)phenyl]-, dihydrochloride
CAS 25787-03-5C24H27ClN8O2
Urea,1'-p-phenylenebis[3-[p-(N,N'-diethylamidino)phenyl]-, dihydrochloride chemical structure, C30H39ClN8O2, CAS 25775-30-8
Urea,1'-p-phenylenebis[3-[p-(N,N'-diethylamidino)phenyl]-, dihydrochloride
CAS 25775-30-8C30H39ClN8O2
Urea,1'-p-phenylenebis[3-[p-(N,N'-diisopropylamidino)phenyl]-, dihydrochloride chemical structure, C34H47ClN8O2, CAS 5568-19-4
Urea,1'-p-phenylenebis[3-[p-(N,N'-diisopropylamidino)phenyl]-, dihydrochloride
CAS 5568-19-4C34H47ClN8O2
N,N'-(2-Bromo-5-hydroxy-1,4-phenylene)bis[N'-(4-cyanophenyl)urea] chemical structure, C22H15BrN6O3, CAS 188773-36-6
N,N'-(2-Bromo-5-hydroxy-1,4-phenylene)bis[N'-(4-cyanophenyl)urea]
CAS 188773-36-6C22H15BrN6O3
1,1'-(1,4-Phenylene)bis(3-(3-(trifluoromethyl)phenyl)urea) chemical structure, C22H16F6N4O2, CAS 882865-87-4
1,1'-(1,4-Phenylene)bis(3-(3-(trifluoromethyl)phenyl)urea)
CAS 882865-87-4C22H16F6N4O2