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Murcko scaffold

Ring system with 3 rings and 27 atoms

55 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
27
Chemicals
55
With full pages
4
Scaffold SMILES

O=C(CN1CCN(S(=O)(=O)C=Cc2ccccc2)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCN(S(=O)(=O)C=Cc2ccccc2)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C21H21ClF3N3O3S, CAS 733015-07-1
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 733015-07-1C21H21ClF3N3O3S
N-(3-Acetylphenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C22H25N3O4S, CAS 790241-82-6
N-(3-Acetylphenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 790241-82-6C22H25N3O4S
N-(2-Cyanophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C21H22N4O3S, CAS 790241-98-4
N-(2-Cyanophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 790241-98-4C21H22N4O3S
2-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]-N-(2,4,6-trichlorophenyl)acetamide chemical structure, C20H20Cl3N3O3S, CAS 790242-65-8
2-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]-N-(2,4,6-trichlorophenyl)acetamide
CAS 790242-65-8C20H20Cl3N3O3S
N-(2,6-Dichlorophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C20H21Cl2N3O3S, CAS 790242-66-9
N-(2,6-Dichlorophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 790242-66-9C20H21Cl2N3O3S
N-(3-Chloro-4-cyanophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C21H21ClN4O3S, CAS 790245-90-8
N-(3-Chloro-4-cyanophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 790245-90-8C21H21ClN4O3S
N-[2-(Methylsulfanyl)phenyl]-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C21H25N3O3S2, CAS 790250-92-9
N-[2-(Methylsulfanyl)phenyl]-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 790250-92-9C21H25N3O3S2
N-(4-Bromophenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C20H22BrN3O3S, CAS 1002272-16-3
N-(4-Bromophenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002272-16-3C20H22BrN3O3S
N-(3-Chloro-2-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C21H24ClN3O3S, CAS 1241684-34-3
N-(3-Chloro-2-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1241684-34-3C21H24ClN3O3S
N-(2,3-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C22H27N3O3S, CAS 1002272-25-4
N-(2,3-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002272-25-4C22H27N3O3S
N-(3-Methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C21H25N3O3S, CAS 1241690-75-4
N-(3-Methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1241690-75-4C21H25N3O3S
N-(5-Chloro-2-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C21H24ClN3O3S, CAS 1002272-30-1
N-(5-Chloro-2-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002272-30-1C21H24ClN3O3S
N-(4-Chloro-2-methoxy-5-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C22H26ClN3O4S, CAS 1002272-34-5
N-(4-Chloro-2-methoxy-5-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002272-34-5C22H26ClN3O4S
N-(4-Methoxyphenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C21H25N3O4S, CAS 871212-54-3
N-(4-Methoxyphenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 871212-54-3C21H25N3O4S
N-(3-Chloro-4-methoxyphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C21H24ClN3O4S, CAS 1002484-29-8
N-(3-Chloro-4-methoxyphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002484-29-8C21H24ClN3O4S
2-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]-N-[2-(propan-2-yl)phenyl]acetamide chemical structure, C23H29N3O3S, CAS 1002484-51-6
2-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]-N-[2-(propan-2-yl)phenyl]acetamide
CAS 1002484-51-6C23H29N3O3S
N-(2,5-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C22H27N3O3S, CAS 1002484-56-1
N-(2,5-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002484-56-1C22H27N3O3S
N-(2,4-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C22H27N3O3S, CAS 1241685-45-9
N-(2,4-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1241685-45-9C22H27N3O3S
N-[2-Methyl-6-(propan-2-yl)phenyl]-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C24H31N3O3S, CAS 1002484-73-2
N-[2-Methyl-6-(propan-2-yl)phenyl]-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 1002484-73-2C24H31N3O3S
2-[4-[(E)-2-Phenylethenyl]sulfonylpiperazin-1-yl]-N-(2,4,6-trimethylphenyl)acetamide chemical structure, C23H29N3O3S, CAS 1002484-84-5
2-[4-[(E)-2-Phenylethenyl]sulfonylpiperazin-1-yl]-N-(2,4,6-trimethylphenyl)acetamide
CAS 1002484-84-5C23H29N3O3S
N-(3-Fluorophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide chemical structure, C20H22FN3O3S, CAS 930897-70-4
N-(3-Fluorophenyl)-2-[4-(2-phenylethenesulfonyl)piperazin-1-yl]acetamide
CAS 930897-70-4C20H22FN3O3S
N-(2-Ethyl-6-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C23H29N3O3S, CAS 1002485-14-4
N-(2-Ethyl-6-methylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002485-14-4C23H29N3O3S
N-(3,4-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C22H27N3O3S, CAS 1002318-73-1
N-(3,4-Dimethylphenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002318-73-1C22H27N3O3S
N-(2-Chlorophenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide chemical structure, C20H22ClN3O3S, CAS 1002405-46-0
N-(2-Chlorophenyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide
CAS 1002405-46-0C20H22ClN3O3S