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Murcko scaffold

Ring system with 3 rings and 27 atoms

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
27
Chemicals
13
With full pages
2
Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCN(S(=O)(=O)C=Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)N1CCN(S(=O)(=O)C=Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

3-(2,3-Dimethoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C23H26N2O5S, CAS 749867-84-3
3-(2,3-Dimethoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one
CAS 749867-84-3C23H26N2O5S
3-(3,4-Dimethoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C23H26N2O5S, CAS 1164503-14-3
3-(3,4-Dimethoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one
CAS 1164503-14-3C23H26N2O5S
1-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-one chemical structure, C22H21F3N2O3S, CAS 851298-48-1
1-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-one
CAS 851298-48-1C22H21F3N2O3S
(E)-3-Phenyl-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one chemical structure, C21H22N2O3S, CAS 931066-70-5
(E)-3-Phenyl-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one
CAS 931066-70-5C21H22N2O3S
3-(4-Methoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C22H24N2O4S, CAS 867276-16-2
3-(4-Methoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one
CAS 867276-16-2C22H24N2O4S
(E)-3-(2-Methoxyphenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one chemical structure, C22H24N2O4S, CAS 872455-83-9
(E)-3-(2-Methoxyphenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one
CAS 872455-83-9C22H24N2O4S
(E)-3-(4-Fluorophenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one chemical structure, C21H21FN2O3S, CAS 1684442-77-0
(E)-3-(4-Fluorophenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one
CAS 1684442-77-0C21H21FN2O3S
(E)-3-(3-Nitrophenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one chemical structure, C21H21N3O5S, CAS 879157-27-4
(E)-3-(3-Nitrophenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one
CAS 879157-27-4C21H21N3O5S
3-(4-Nitrophenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C21H21N3O5S, CAS 852554-65-5
3-(4-Nitrophenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one
CAS 852554-65-5C21H21N3O5S
(E)-3-(2,5-Dimethoxyphenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one chemical structure, C23H26N2O5S, CAS 848175-81-5
(E)-3-(2,5-Dimethoxyphenyl)-1-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]prop-2-en-1-one
CAS 848175-81-5C23H26N2O5S
3-(2-Methoxy-5-methylphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C23H26N2O4S, CAS 878948-54-0
3-(2-Methoxy-5-methylphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one
CAS 878948-54-0C23H26N2O4S
3-(3-Bromophenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C21H21BrN2O3S, CAS 924712-61-8
3-(3-Bromophenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one
CAS 924712-61-8C21H21BrN2O3S
3-(5-Bromo-2-methoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C22H23BrN2O4S, CAS 931607-87-3
3-(5-Bromo-2-methoxyphenyl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]prop-2-en-1-one
CAS 931607-87-3C22H23BrN2O4S