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Murcko scaffold

Ring system with 4 rings and 28 atoms

34 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
34
With full pages
7
Scaffold SMILES

O=C(C1=CC(=O)N(CCCN2CCOCC2)C1c1ccccc1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(CCCN2CCOCC2)C1c1ccccc1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

5-(2-Fluorophenyl)-4-(2-furoyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H23FN2O5, CAS 378778-14-4
5-(2-Fluorophenyl)-4-(2-furoyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 378778-14-4C22H23FN2O5
5-(3,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H28N2O7, CAS 381682-30-0
5-(3,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 381682-30-0C24H28N2O7
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(4-methylphenyl)-1-[3-(morpholin-4-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H26N2O5, CAS 381203-00-5
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(4-methylphenyl)-1-[3-(morpholin-4-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 381203-00-5C23H26N2O5
4-(Furan-2-carbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H30N2O5, CAS 381207-64-3
4-(Furan-2-carbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 381207-64-3C25H30N2O5
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one chemical structure, C22H23ClN2O5, CAS 381708-46-9
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one
CAS 381708-46-9C22H23ClN2O5
5-(3-Bromophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one chemical structure, C22H23BrN2O5, CAS 378771-34-7
5-(3-Bromophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one
CAS 378771-34-7C22H23BrN2O5
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-[3-(morpholin-4-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H26N2O6, CAS 381698-77-7
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-[3-(morpholin-4-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 381698-77-7C23H26N2O6
5-(4-Fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one chemical structure, C22H23FN2O5, CAS 381710-47-0
5-(4-Fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one
CAS 381710-47-0C22H23FN2O5
(4E)-5-(4-Ethoxyphenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione chemical structure, C24H28N2O6, CAS 371214-02-7
(4E)-5-(4-Ethoxyphenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione
CAS 371214-02-7C24H28N2O6
5-(2,3-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one chemical structure, C24H28N2O7, CAS 370575-69-2
5-(2,3-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one
CAS 370575-69-2C24H28N2O7
3-Hydroxy-4-[(5-methylfuran-2-yl)carbonyl]-1-[3-(morpholin-4-yl)propyl]-5-(4-propoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H32N2O6, CAS 616859-72-4
3-Hydroxy-4-[(5-methylfuran-2-yl)carbonyl]-1-[3-(morpholin-4-yl)propyl]-5-(4-propoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 616859-72-4C26H32N2O6
5-(2,5-Dimethoxyphenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-[3-(4-morpholinyl)propyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H30N2O7, CAS 636990-38-0
5-(2,5-Dimethoxyphenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-[3-(4-morpholinyl)propyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 636990-38-0C25H30N2O7
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-4-[(5-methyl(2-furyl))carbonyl]-1-(3-m orpholin-4-ylpropyl)-3-pyrrolin-2-one chemical structure, C27H34N2O7, CAS 636990-36-8
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-4-[(5-methyl(2-furyl))carbonyl]-1-(3-m orpholin-4-ylpropyl)-3-pyrrolin-2-one
CAS 636990-36-8C27H34N2O7
4-(Furan-2-carbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H30N2O6, CAS 636991-72-5
4-(Furan-2-carbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 636991-72-5C25H30N2O6
3-Hydroxy-4-[(5-methylfuran-2-yl)carbonyl]-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H32N2O6, CAS 614748-09-3
3-Hydroxy-4-[(5-methylfuran-2-yl)carbonyl]-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 614748-09-3C26H32N2O6
4-(Furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C22H24N2O5, CAS 381194-31-6
4-(Furan-2-carbonyl)-3-hydroxy-1-(3-morpholinopropyl)-5-phenyl-1H-pyrrol-2(5H)-one
CAS 381194-31-6C22H24N2O5
4-(2-Furoyl)-3-hydroxy-1-(3-(4-morpholinyl)propyl)-5-(4-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H23N3O7, CAS 378760-44-2
4-(2-Furoyl)-3-hydroxy-1-(3-(4-morpholinyl)propyl)-5-(4-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 378760-44-2C22H23N3O7
5-(3-Ethoxyphenyl)-4-(furan-2-ylcarbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H28N2O6, CAS 619274-38-3
5-(3-Ethoxyphenyl)-4-(furan-2-ylcarbonyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 619274-38-3C24H28N2O6
4-(2-Furylcarbonyl)-3-hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(3-morpholin-4-y lpropyl)-3-pyrrolin-2-one chemical structure, C26H32N2O7, CAS 638134-39-1
4-(2-Furylcarbonyl)-3-hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(3-morpholin-4-y lpropyl)-3-pyrrolin-2-one
CAS 638134-39-1C26H32N2O7
5-(3,4-Diethoxyphenyl)-3-hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(3-morpholi n-4-ylpropyl)-3-pyrrolin-2-one chemical structure, C27H34N2O7, CAS 620119-14-4
5-(3,4-Diethoxyphenyl)-3-hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(3-morpholi n-4-ylpropyl)-3-pyrrolin-2-one
CAS 620119-14-4C27H34N2O7
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione chemical structure, C25H30N2O6, CAS 384801-28-9
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione
CAS 384801-28-9C25H30N2O6
3-Hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(3-morpholin-4-ylpropyl)-5-(3-prop-2-enyloxyphenyl)-3-pyrrolin-2-one chemical structure, C26H30N2O6, CAS 620117-00-2
3-Hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(3-morpholin-4-ylpropyl)-5-(3-prop-2-enyloxyphenyl)-3-pyrrolin-2-one
CAS 620117-00-2C26H30N2O6
4-(2-Furoyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-5-(4-propoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H30N2O6, CAS 616859-70-2
4-(2-Furoyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-5-(4-propoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 616859-70-2C25H30N2O6
4-(2-Furylcarbonyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-5-(3-propoxyphenyl)-3-pyrrolin-2-one chemical structure, C25H30N2O6, CAS 619272-31-0
4-(2-Furylcarbonyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-5-(3-propoxyphenyl)-3-pyrrolin-2-one
CAS 619272-31-0C25H30N2O6