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Murcko scaffold

Ring system with 4 rings and 28 atoms

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
23
With full pages
6
Scaffold SMILES

O=C(C1=CC(=O)N(CCCN2CCOCC2)C1c1ccccc1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(CCCN2CCOCC2)C1c1ccccc1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

2-(3,4-Dimethoxyphenyl)-4-hydroxy-1-(3-morpholin-4-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C24H28N2O6S, CAS 378761-84-3
2-(3,4-Dimethoxyphenyl)-4-hydroxy-1-(3-morpholin-4-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 378761-84-3C24H28N2O6S
5-(3-Bromophenyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H23BrN2O4S, CAS 380888-54-0
5-(3-Bromophenyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 380888-54-0C22H23BrN2O4S
5-(4-Fluorophenyl)-3-hydroxy-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H23FN2O4S, CAS 378221-64-8
5-(4-Fluorophenyl)-3-hydroxy-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 378221-64-8C22H23FN2O4S
3-Hydroxy-5-(4-methoxyphenyl)-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C23H26N2O5S, CAS 380904-46-1
3-Hydroxy-5-(4-methoxyphenyl)-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380904-46-1C23H26N2O5S
3-Hydroxy-5-(4-isopropylphenyl)-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C25H30N2O4S, CAS 378757-79-0
3-Hydroxy-5-(4-isopropylphenyl)-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 378757-79-0C25H30N2O4S
5-(2-Fluorophenyl)-3-hydroxy-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H23FN2O4S, CAS 378766-50-8
5-(2-Fluorophenyl)-3-hydroxy-1-(3-morpholinopropyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 378766-50-8C22H23FN2O4S
5-(3,4-Dichlorophenyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H22Cl2N2O4S, CAS 380589-46-8
5-(3,4-Dichlorophenyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 380589-46-8C22H22Cl2N2O4S
3-Hydroxy-1-(3-morpholinopropyl)-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H24N2O4S, CAS 380901-29-1
3-Hydroxy-1-(3-morpholinopropyl)-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380901-29-1C22H24N2O4S
2-(4-Chlorophenyl)-4-hydroxy-1-(3-morpholin-4-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C22H23ClN2O4S, CAS 378755-56-7
2-(4-Chlorophenyl)-4-hydroxy-1-(3-morpholin-4-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 378755-56-7C22H23ClN2O4S
(4E)-5-(2,3-Dimethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione chemical structure, C24H28N2O6S, CAS 370575-01-2
(4E)-5-(2,3-Dimethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione
CAS 370575-01-2C24H28N2O6S
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione chemical structure, C24H28N2O5S, CAS 371925-03-0
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[3-(morpholin-4-yl)propyl]pyrrolidine-2,3-dione
CAS 371925-03-0C24H28N2O5S
3-Hydroxy-5-(3-methoxyphenyl)-1-(3-morpholin-4-ylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C23H26N2O5S, CAS 433321-99-4
3-Hydroxy-5-(3-methoxyphenyl)-1-(3-morpholin-4-ylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one
CAS 433321-99-4C23H26N2O5S
5-[4-(Allyloxy)phenyl]-3-hydroxy-1-[3-(4-morpholinyl)propyl]-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H28N2O5S, CAS 616858-94-7
5-[4-(Allyloxy)phenyl]-3-hydroxy-1-[3-(4-morpholinyl)propyl]-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 616858-94-7C25H28N2O5S
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H30N2O6S, CAS 636991-46-3
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 636991-46-3C25H30N2O6S
3-Hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H30N2O5S, CAS 615270-68-3
3-Hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 615270-68-3C25H30N2O5S
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(3-morpholin-4-ylpropyl)-4-(2-thieny lcarbonyl)-3-pyrrolin-2-one chemical structure, C26H32N2O6S, CAS 636991-47-4
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(3-morpholin-4-ylpropyl)-4-(2-thieny lcarbonyl)-3-pyrrolin-2-one
CAS 636991-47-4C26H32N2O6S
4-Hydroxy-1-(3-morpholin-4-ylpropyl)-2-(4-propoxyphenyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C25H30N2O5S, CAS 615270-73-0
4-Hydroxy-1-(3-morpholin-4-ylpropyl)-2-(4-propoxyphenyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 615270-73-0C25H30N2O5S
2-(3-Ethoxyphenyl)-4-hydroxy-1-(3-morpholin-4-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C24H28N2O5S, CAS 619271-44-2
2-(3-Ethoxyphenyl)-4-hydroxy-1-(3-morpholin-4-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 619271-44-2C24H28N2O5S
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-4-(2-thienylcarbon yl)-3-pyrrolin-2-one chemical structure, C26H32N2O6S, CAS 573973-26-9
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-(3-morpholin-4-ylpropyl)-4-(2-thienylcarbon yl)-3-pyrrolin-2-one
CAS 573973-26-9C26H32N2O6S
3-Hydroxy-5-(4-methylphenyl)-1-(3-morpholin-4-ylpropyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H26N2O4S, CAS 380887-44-5
3-Hydroxy-5-(4-methylphenyl)-1-(3-morpholin-4-ylpropyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 380887-44-5C23H26N2O4S
3-Hydroxy-1-(3-morpholinopropyl)-5-(3-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H23N3O6S, CAS 380570-55-8
3-Hydroxy-1-(3-morpholinopropyl)-5-(3-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380570-55-8C22H23N3O6S
3-Hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[3-(prop-2-en-1-yloxy)phenyl]-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H28N2O5S, CAS 620151-85-1
3-Hydroxy-1-[3-(morpholin-4-yl)propyl]-5-[3-(prop-2-en-1-yloxy)phenyl]-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 620151-85-1C25H28N2O5S
3-Hydroxy-1-(3-morpholin-4-ylpropyl)-5-(3-propoxyphenyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C25H30N2O5S, CAS 620151-18-0
3-Hydroxy-1-(3-morpholin-4-ylpropyl)-5-(3-propoxyphenyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one
CAS 620151-18-0C25H30N2O5S