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Murcko scaffold

Ring system with 2 rings and 16 atoms

88 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
88
With full pages
13
Scaffold SMILES

O=C1OCOC(=O)C1=CNc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1OCOC(=O)C1=CNc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 88 of 88 chemicals

5-[(2-Bromo-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione chemical structure, C13H12BrNO4, CAS 187278-04-2
5-[(2-Bromo-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione
CAS 187278-04-2C13H12BrNO4
5-[(2,4-Dichloroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C13H11Cl2NO4, CAS 187278-07-5
5-[(2,4-Dichloroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 187278-07-5C13H11Cl2NO4
4-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzenesulfonamide chemical structure, C13H14N2O6S, CAS 25063-79-0
4-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzenesulfonamide
CAS 25063-79-0C13H14N2O6S
5-[[(4-Iodophenyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C13H12INO4, CAS 909344-69-0
5-[[(4-Iodophenyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 909344-69-0C13H12INO4
Methyl4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)benzoate chemical structure, C15H15NO6, CAS 230631-82-0
Methyl4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)benzoate
CAS 230631-82-0C15H15NO6
5-(((3-Chloro-4-methoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H14ClNO5, CAS 909345-45-5
5-(((3-Chloro-4-methoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 909345-45-5C14H14ClNO5
5-[[(4-Butoxyphenyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C17H21NO5, CAS 230631-83-1
5-[[(4-Butoxyphenyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 230631-83-1C17H21NO5
5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione chemical structure, C13H12BrNO4, CAS 723280-91-9
5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione
CAS 723280-91-9C13H12BrNO4
5-[[(2-Bromophenyl)amino](methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H14BrNO4S, CAS 912824-70-5
5-[[(2-Bromophenyl)amino](methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 912824-70-5C14H14BrNO4S
5-(((3,4-Dimethylphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H17NO4, CAS 25063-93-8
5-(((3,4-Dimethylphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 25063-93-8C15H17NO4
5-[[(2,4-Dimethoxyphenyl)amino](methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C16H19NO6S, CAS 141993-72-8
5-[[(2,4-Dimethoxyphenyl)amino](methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 141993-72-8C16H19NO6S
5-(((3,4-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H17NO6, CAS 213699-53-7
5-(((3,4-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 213699-53-7C15H17NO6
5-{[(2,4-Dimethoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H17NO6, CAS 148018-39-7
5-{[(2,4-Dimethoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 148018-39-7C15H17NO6
5-((3-Hydroxy-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H15NO6, CAS 205448-27-7
5-((3-Hydroxy-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 205448-27-7C14H15NO6
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate chemical structure, C16H17NO7, CAS 205448-64-2
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
CAS 205448-64-2C16H17NO7
4-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxyphenyl acetate chemical structure, C16H17NO7, CAS 205448-73-3
4-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxyphenyl acetate
CAS 205448-73-3C16H17NO7
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-hydroxybenzoate chemical structure, C15H15NO7, CAS 417723-29-6
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-hydroxybenzoate
CAS 417723-29-6C15H15NO7
5-(4-Methoxy-3-methoxycarbonylanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C16H17NO7, CAS 947763-41-9
5-(4-Methoxy-3-methoxycarbonylanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 947763-41-9C16H17NO7
2-(Diethylamino)ethyl 4-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}benzoate chemical structure, C20H26N2O6, CAS 1105215-80-2
2-(Diethylamino)ethyl 4-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}benzoate
CAS 1105215-80-2C20H26N2O6
N-Carbamoyl-4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzenesulfonamide chemical structure, C14H15N3O7S, CAS 1170023-78-5
N-Carbamoyl-4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzenesulfonamide
CAS 1170023-78-5C14H15N3O7S
N-Carbamimidoyl-4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzenesulfonamide chemical structure, C14H16N4O6S, CAS 1172404-84-0
N-Carbamimidoyl-4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzenesulfonamide
CAS 1172404-84-0C14H16N4O6S
N-[3-[[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino]phenyl]-N-methylacetamide chemical structure, C16H18N2O5, CAS 1158757-19-7
N-[3-[[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino]phenyl]-N-methylacetamide
CAS 1158757-19-7C16H18N2O5
5-({[3-Iodo-4-(methoxy)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H14INO5, CAS 1300031-69-9
5-({[3-Iodo-4-(methoxy)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 1300031-69-9C14H14INO5
2,2-Dimethyl-5-{[2-(methylsulfanyl)anilino]methylene}-1,3-dioxane-4,6-dione chemical structure, C14H15NO4S, CAS 548457-74-5
2,2-Dimethyl-5-{[2-(methylsulfanyl)anilino]methylene}-1,3-dioxane-4,6-dione
CAS 548457-74-5C14H15NO4S