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Murcko scaffold

Ring system with 2 rings and 16 atoms

88 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
88
With full pages
13
Scaffold SMILES

O=C1OCOC(=O)C1=CNc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1OCOC(=O)C1=CNc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 88 chemicals

5-(Anilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C13H13NO4, CAS 15568-92-0
5-(Anilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 15568-92-0C13H13NO4
5-{[(4-Fluorophenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C13H12FNO4, CAS 332129-58-5
5-{[(4-Fluorophenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 332129-58-5C13H12FNO4
5-{[(2-Ethoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H17NO5, CAS 369395-87-9
5-{[(2-Ethoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 369395-87-9C15H17NO5
5-[[(2,5-Dimethoxyphenyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H17NO6, CAS 97545-51-2
5-[[(2,5-Dimethoxyphenyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 97545-51-2C15H17NO6
5-(((2-Fluorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C13H12FNO4, CAS 369395-32-4
5-(((2-Fluorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 369395-32-4C13H12FNO4
2,2-Dimethyl-5-[[3-(trifluoromethyl)anilino]methylidene]-1,3-dioxane-4,6-dione chemical structure, C14H12F3NO4, CAS 25063-55-2
2,2-Dimethyl-5-[[3-(trifluoromethyl)anilino]methylidene]-1,3-dioxane-4,6-dione
CAS 25063-55-2C14H12F3NO4
5-[(2-Methoxyanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H15NO5, CAS 25165-68-8
5-[(2-Methoxyanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 25165-68-8C14H15NO5
5-(((3-Fluorophenyl)amino)methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C13H12FNO4, CAS 25063-54-1
5-(((3-Fluorophenyl)amino)methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 25063-54-1C13H12FNO4
5-{[(2-Ethylphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H17NO4, CAS 370848-61-6
5-{[(2-Ethylphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 370848-61-6C15H17NO4
2,2-Dimethyl-5-({[4-(propan-2-yl)phenyl]amino}methylidene)-1,3-dioxane-4,6-dione chemical structure, C16H19NO4, CAS 384358-53-6
2,2-Dimethyl-5-({[4-(propan-2-yl)phenyl]amino}methylidene)-1,3-dioxane-4,6-dione
CAS 384358-53-6C16H19NO4
5-[(3-Methoxyphenylamino)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H15NO5, CAS 213699-52-6
5-[(3-Methoxyphenylamino)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 213699-52-6C14H15NO5
5-{[(4-Methoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H15NO5, CAS 25063-43-8
5-{[(4-Methoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 25063-43-8C14H15NO5
5-{[(4-Ethoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H17NO5, CAS 370849-74-4
5-{[(4-Ethoxyphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 370849-74-4C15H17NO5
Ethyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzoate chemical structure, C16H17NO6, CAS 205810-04-4
Ethyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzoate
CAS 205810-04-4C16H17NO6
N-(4-{[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}phenyl)acetamide chemical structure, C15H16N2O5, CAS 370846-47-2
N-(4-{[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}phenyl)acetamide
CAS 370846-47-2C15H16N2O5
5-({[2-Chloro-5-(trifluoromethyl)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H11ClF3NO4, CAS 369398-13-0
5-({[2-Chloro-5-(trifluoromethyl)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 369398-13-0C14H11ClF3NO4
5-((Mesitylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C16H19NO4, CAS 370852-73-6
5-((Mesitylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 370852-73-6C16H19NO4
5-(((4-Chloro-2,5-dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H16ClNO6, CAS 370850-05-8
5-(((4-Chloro-2,5-dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 370850-05-8C15H16ClNO6
5-({[4-Chloro-2-(trifluoromethyl)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H11ClF3NO4, CAS 383895-27-0
5-({[4-Chloro-2-(trifluoromethyl)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 383895-27-0C14H11ClF3NO4
5-(((3,4-Difluorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C13H11F2NO4, CAS 369398-68-5
5-(((3,4-Difluorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 369398-68-5C13H11F2NO4
5-{[(2-Fluoro-5-methylphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C14H14FNO4, CAS 370847-20-4
5-{[(2-Fluoro-5-methylphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 370847-20-4C14H14FNO4
5-{[(3-Acetylphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione chemical structure, C15H15NO5, CAS 370852-60-1
5-{[(3-Acetylphenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS 370852-60-1C15H15NO5
2-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzoic acid methyl ester chemical structure, C15H15NO6, CAS 185130-13-6
2-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzoic acid methyl ester
CAS 185130-13-6C15H15NO6
2,2-Dimethyl-5-[[4-(trifluoromethyl)anilino]methylidene]-1,3-dioxane-4,6-dione chemical structure, C14H12F3NO4, CAS 681472-89-9
2,2-Dimethyl-5-[[4-(trifluoromethyl)anilino]methylidene]-1,3-dioxane-4,6-dione
CAS 681472-89-9C14H12F3NO4