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Murcko scaffold

RefChem:381586 scaffold

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
22
With full pages
3
Scaffold SMILES

O=C(NCC(=O)N1CCCCC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the RefChem:381586 page
Murcko scaffold O=C(NCC(=O)N1CCCCC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

RefChem:381586 chemical structure, C14H18N2O2, CAS 51769-86-9
RefChem:381586
CAS 51769-86-9C14H18N2O2
1-(2-Benzamidoacetyl)piperidine-4-carboxylic acid chemical structure, C15H18N2O4, CAS 887833-71-8
1-(2-Benzamidoacetyl)piperidine-4-carboxylic acid
CAS 887833-71-8C15H18N2O4
Acetic acid, ((1-((2S)-2-((4-((hydroxyamino)iminomethyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester chemical structure, C20H28N4O6, CAS 170094-62-9
Acetic acid, ((1-((2S)-2-((4-((hydroxyamino)iminomethyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester
CAS 170094-62-9C20H28N4O6
Ro-44-3888 chemical structure, C18H24N4O5, CAS 144412-18-0
Ro-44-3888
CAS 144412-18-0C18H24N4O5
((1-((2R)-2-(4-Carbamimidoylbenzamido)propanoyl)piperidin-4-yl)oxy)acetic acid chemical structure, C18H24N4O5, CAS 144412-20-4
((1-((2R)-2-(4-Carbamimidoylbenzamido)propanoyl)piperidin-4-yl)oxy)acetic acid
CAS 144412-20-4C18H24N4O5
[[1-[(R)-2-[(4-Amidinobenzoyl)amino]propionyl]piperidin-4-yl]oxy]acetic acid chemical structure, C18H24N4O5
[[1-[(R)-2-[(4-Amidinobenzoyl)amino]propionyl]piperidin-4-yl]oxy]acetic acid
C18H24N4O5
1-(2-Benzamidoacetyl)piperidine-3-carboxylic acid chemical structure, C15H18N2O4, CAS 951957-39-4
1-(2-Benzamidoacetyl)piperidine-3-carboxylic acid
CAS 951957-39-4C15H18N2O4
2-[[1-[2-[[4-(Aminoiminomethyl)benzoyl]methylamino]acetyl]-4-piperidinyl]oxy]acetic acid chemical structure, C18H24N4O5, CAS 146118-09-4
2-[[1-[2-[[4-(Aminoiminomethyl)benzoyl]methylamino]acetyl]-4-piperidinyl]oxy]acetic acid
CAS 146118-09-4C18H24N4O5
4-Methyl-N-[2-oxo-2-(1-piperidinyl)ethyl]benzamide chemical structure, C15H20N2O2, CAS 959240-81-4
4-Methyl-N-[2-oxo-2-(1-piperidinyl)ethyl]benzamide
CAS 959240-81-4C15H20N2O2
4-Amino-N-[2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl]benzamide chemical structure, C16H23N3O2, CAS 1016799-80-6
4-Amino-N-[2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl]benzamide
CAS 1016799-80-6C16H23N3O2
4-Acetyl-N-((S)-6-amino-1-((3R,5S)-3,5-diaminopiperidin-1-yl)-1-oxohexan-2-yl)benzamide chemical structure, C20H31N5O3, CAS 1178586-99-6
4-Acetyl-N-((S)-6-amino-1-((3R,5S)-3,5-diaminopiperidin-1-yl)-1-oxohexan-2-yl)benzamide
CAS 1178586-99-6C20H31N5O3
N-(2-(4-((2-Methoxyethoxy)methyl)piperidin-1-yl)-2-oxoethyl)benzamide chemical structure, C18H26N2O4, CAS 1251581-97-1
N-(2-(4-((2-Methoxyethoxy)methyl)piperidin-1-yl)-2-oxoethyl)benzamide
CAS 1251581-97-1C18H26N2O4
4-(Methanesulfonyl)-N-methyl-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-nitrobenzamide chemical structure, C17H23N3O6S, CAS 1426842-77-4
4-(Methanesulfonyl)-N-methyl-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-nitrobenzamide
CAS 1426842-77-4C17H23N3O6S
N-(2-(4-(Isobutylsulfonyl)piperidin-1-yl)-2-oxoethyl)benzamide chemical structure, C18H26N2O4S, CAS 1797176-08-9
N-(2-(4-(Isobutylsulfonyl)piperidin-1-yl)-2-oxoethyl)benzamide
CAS 1797176-08-9C18H26N2O4S
N-(2-(4-Aminopiperidin-1-yl)-2-oxoethyl)benzamide hydrochloride chemical structure, C14H20ClN3O2, CAS 2031469-24-4
N-(2-(4-Aminopiperidin-1-yl)-2-oxoethyl)benzamide hydrochloride
CAS 2031469-24-4C14H20ClN3O2
N-(2-(3-Aminopiperidin-1-yl)-2-oxoethyl)benzamide hydrochloride chemical structure, C14H20ClN3O2, CAS 1834557-04-8
N-(2-(3-Aminopiperidin-1-yl)-2-oxoethyl)benzamide hydrochloride
CAS 1834557-04-8C14H20ClN3O2
N-(2-(3-Aminopiperidin-1-yl)-2-oxoethyl)-4-(trifluoromethyl)benzamide hydrochloride chemical structure, C15H19ClF3N3O2, CAS 1839700-02-5
N-(2-(3-Aminopiperidin-1-yl)-2-oxoethyl)-4-(trifluoromethyl)benzamide hydrochloride
CAS 1839700-02-5C15H19ClF3N3O2
N-(2-(3-Aminopiperidin-1-yl)-2-oxoethyl)-4-(trifluoromethyl)benzamide chemical structure, C15H18F3N3O2, CAS 1839700-01-4
N-(2-(3-Aminopiperidin-1-yl)-2-oxoethyl)-4-(trifluoromethyl)benzamide
CAS 1839700-01-4C15H18F3N3O2
N-(2-(4-(Aminomethyl)piperidin-1-yl)-2-oxoethyl)benzamide hydrochloride chemical structure, C15H22ClN3O2, CAS 1576986-28-1
N-(2-(4-(Aminomethyl)piperidin-1-yl)-2-oxoethyl)benzamide hydrochloride
CAS 1576986-28-1C15H22ClN3O2
N-(2-(4-(Hydrazinecarbonyl)piperidin-1-yl)-2-oxoethyl)benzamide chemical structure, C15H20N4O3, CAS 2225833-70-3
N-(2-(4-(Hydrazinecarbonyl)piperidin-1-yl)-2-oxoethyl)benzamide
CAS 2225833-70-3C15H20N4O3
N-[2-(2-Cyano-3,3-dimethylpiperidin-1-yl)-2-oxoethyl]-3-methoxybenzamide chemical structure, C18H23N3O3, CAS 2224246-21-1
N-[2-(2-Cyano-3,3-dimethylpiperidin-1-yl)-2-oxoethyl]-3-methoxybenzamide
CAS 2224246-21-1C18H23N3O3
N-[2-(4,4-Difluoropiperidin-1-yl)-2-oxoethyl]benzamide chemical structure, C14H16F2N2O2, CAS 2327531-16-6
N-[2-(4,4-Difluoropiperidin-1-yl)-2-oxoethyl]benzamide
CAS 2327531-16-6C14H16F2N2O2